Article
Chemistry, Multidisciplinary
Ya Wang, Shiqiang Mu, Xin Li, Qiuling Song
Summary: A facile synthesis method for 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. This is the first time halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope, and valuable products.
CHINESE CHEMICAL LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Valentin Karabelyov, Magdalena Kondeva-Burdina, Violina T. Angelova
Summary: Selective monoamine oxidase type B (MAO-B) inhibitors are used as adjuvants for treating early motor symptoms of Parkinson's disease. Recent research has focused on updating and summarizing inhibitors with oxadiazole scaffolds to explore more possibilities for compound design and ensure their safe use.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Nguyen Phu Quy, Bui Thi Buu Hue, Kiep Minh Do, Ha Thi Kim Quy, Tran Quang De, Tran Thi Bich Phuong, Pham Cong Trang, Nguyen Cuong Quoc, Hiroyuki Morita
Summary: In this study, two series of 2-substituted benzimidazole conjugated 1,3,4-oxadiazole derivatives were synthesized and evaluated for their cytotoxic activities against three human cancer cell lines. Compounds 4b, 4d, and 4i exhibited strong antitumor activity and are potential candidates for further characterization.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Chemistry, Physical
Sunil L. Dhonnar, Rahul A. More, Vishnu A. Adole, Bapu S. Jagdale, Nutan Sadgir, Santosh S. Chobe
Summary: A series of 1,3,4-oxadiazole derivatives were synthesized and characterized. The synthesized compounds exhibited significant antibacterial and antifungal activity, as well as good antioxidant properties and low cytotoxicity. Three compounds showed higher antibacterial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Saira Naseem, Ahmed Temirak, Aqeel Imran, Saquib Jalil, Shamool Fatima, Parham Taslimi, Jamshed Iqbal, Mussarat Tasleem, Muhammad Nawaz Tahir, Zahid Shafiq
Summary: In this study, new 1,3,4-oxadiazole derivatives were synthesized and tested as novel inhibitors of monoamine oxidase and cholinesterase enzymes. Several compounds showed promising inhibitory effects on these enzymes, with some compounds displaying multitargeting activity. These newly synthesized analogues represent potential lead compounds for the development of neurological disease treatments.
Article
Chemistry, Medicinal
Mukund P. Tantak, Monika Malik, Linus Klingler, Zachary Olson, Anil Kumar, Rachna Sadana, Dalip Kumar
Summary: A series of novel indolyl-alpha-keto-1,3,4-oxadiazole derivatives were synthesized via molecular iodine-mediated oxidative cyclization. Compound 19e, with a 3,4,5-trimethoxyphenyl motif, exhibited significant antiproliferative activity against various cancer cell lines. Molecular docking studies suggested a potential binding mode for compound 19e in the colchicine binding site of tubulin, inhibiting tubulin polymerization and inducing apoptosis while not causing necrosis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Sherif M. H. Sanad, Ahmed E. M. Mekky, Ahmed A. M. Ahmed
Summary: In this study, a new series of pyrrole-linked mono- and bis(1,3,4-oxadiazole) hybrids were synthesized and their cytotoxicity was tested. The hybrids attached to p-nitro and p-acetoxy units showed promising anticancer activity and potential as thymidylate synthase inhibitors.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Physical
Farman Ali Khan, Aziz Ur Rehman, Muhammad Athar Abbasi, Sahib Gul Afridi, Asifullah Khan, Muhammad Arif Lodhi, Ajmal Khan
Summary: The study investigated the Michaelis-Menten kinetics of urease inhibitors with acetamide hybrids of N-substituted 1,3,4-oxadiazoles and piperidines. Competitive enzyme inhibition was observed with Ki values ranging from 3.11 +/- 0.2 to 5.20 +/- 0.7 μM, and molecular docking supported the inhibitory mechanisms. The compounds were found to be non-toxic to human neutrophils and plants, showing promising potential for further development.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Marcin Luczyliski, Kornelia Kubiesa, Agnieszka Kudelko
Summary: A series of new symmetrical 2,5-dialkyl-1,3,4-oxadiazoles containing substituted alkyl groups at the terminal positions with substituents, such as bromine, isopropyloxycarbonylmethylamino, and carboxymethylamino, were successfully synthesized. The structure of all products was confirmed by conventional spectroscopic methods including H-1 NMR, C-13 NMR, and HRMS.
Article
Oncology
Sushmitha Bujji, Edigi P. Kumar, K. Sivan, D. H. Manjunatha, N. J. P. Subhashini
Summary: A synthetic route to link benzoxazoles with oxadiazoles was designed, resulting in a better pharmacophore for anticancer activity. A series of novel amide derivatives were synthesized and screened in vitro, and compound 10b exhibited potent anticancer activity in three cell lines.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Hala E. M. Tolan, Asmaa M. Fahim, Eman H. I. Ismael
Summary: In this study, different 1,3,4-oxadiazoles, 1,2,4-triazoles, and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine ring system were synthesized through the reaction of hydrazide derivatives with CS 2 in ethanolic potassium hydroxide, followed by acidification with HCl. The synthesized compounds exhibited anti-tumor activity against HepG2 and MCF-7 cell lines, and the results were confirmed through docking simulation with PDBID: 4hqd and PDBID: 5h38.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Medicinal
Vivek K. Gour, Shaikh Yahya, Mohammad Shahar Yar
Summary: Oxadiazoles and thiadiazoles have versatile biological applications and stability, making them potential candidates for the development of new drugs.
ARCHIV DER PHARMAZIE
(2023)
Article
Nanoscience & Nanotechnology
Martina Sciarretta, Mariam Barawi, Cristina Navio, Victor A. de la Pena O'Shea, Matias Blanco, Jose Aleman
Summary: This study presents the immobilization of TiO2 nanoparticles on graphene acid (GA) and investigates the resulting material's photocatalytic activity in the synthesis of 1,3,4-oxadiazoles. The GA-TiO2 composite exhibits enhanced photoactivity compared to bare TiO2 and demonstrates recyclability and stability. The efficient synthesis of a variety of oxadiazoles highlights the optimal performance of this multifunctional photocatalytic material.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Agriculture, Multidisciplinary
Shichuang Ma, Weiqi Jiang, Qi Li, Tian Li, Wenjun Wu, Hangyu Bai, Baojun Shi
Summary: A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure were synthesized and evaluated for their insecticidal activity against several aphid species, showing promising results. The compounds demonstrated potential insecticidal effects by disrupting mitochondria and nuclear membranes in insect midgut cells, particularly against Eriosoma lanigerum. Further studies also indicated the inhibitory action of one compound on carboxylesterase in the target insect, suggesting its potential as a new pesticide.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Kingshuk Mahanty, Atreyee Halder, Suman De Sarkar
Summary: Electrochemical routes for the synthesis of N-sulfonyl amidines and 1,3,4-oxadiazoles are reported through the activation of DMF molecule. The successful implementation of electro-redox reactions eliminates the need for stoichiometric chemical oxidants and minimizes reagent waste generation. Both protocols exhibit broad functional group tolerance, allowing a wide substrate scope with 47-94% isolated yield. Several control experiments and cyclic voltammetry studies were conducted, providing detailed mechanistic insights into these transformations.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Correction
Computer Science, Interdisciplinary Applications
Tirumala Paruchuri, Gangadhara Rao Kancharla, Suresh Dara, Rohit Kumar Yadav, Surender Singh Jadav, Swetha Dhamercherla, Ankit Vidyarthi
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2023)
Article
Chemistry, Organic
Mohamed Jawed Ahsan, Mohammad Yusuf, Salahuddin, Md Afroz Bakht, Mohamad Taleuzzaman, Bharat Vashishtha, Arunkumar Thiriveedhi
Summary: A green and efficient catalyst-free synthesis of 4'-(substituted phenyl)spiro[indoline-3,3'-[1,2,4]triazolidine]-2,5'-diones was reported, with excellent yields. The one-pot multi-component synthesis in a glycerol-water solvent system showed environmental friendliness and simplicity. The synthesized compounds exhibited significant antibacterial, antifungal, and antitubercular activities, with 4'-(4-chlorophenyl)spiro[indoline-3,3'-[1,2,4]triazolidine]-2,5'-dione as the most potent compound in the series.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Review
Cardiac & Cardiovascular Systems
Md Sayeed Akhtar, Md Quamrul Hassan, Aisha Siddiqui, Sirajudeen S. Alavudeen, Obaid Afzal, Abdulmalik S. A. Altamimi, Syed Obaidur Rahman, Mallika Khurana, Mohamed Jawed Ahsan, Arun Kumar, Fauzia Tabassum
Summary: Inotropic agents are commonly used in patients with acute decompensated heart failure, but their use is limited due to certain pharmacological constraints. Calcium ion sensitisers, such as levosimendan, show promise as emerging therapeutic alternatives by increasing the sensitivity of cardiomyocytes to calcium ions. Levosimendan has unique pharmacology that justifies its use in a wide range of heart failure cases and cardiac surgeries, and it has been reported to be more effective than classical inotropes in maintaining cardiac mechanical efficacy and reducing congestion.
Review
Chemistry, Organic
Abhishek Shankar Sharma, Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Sonakshi Tyagi, Mohammad Shahar Yar, Mohamed Jawed Ahsan
Summary: Due to their diverse applications, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds in industrial and synthetic organic chemistry. They have shown potential in various medical conditions and synthetic protocols have been developed to explore their structure-activity relationship for further research.
CURRENT ORGANIC SYNTHESIS
(2023)
Review
Biochemistry & Molecular Biology
Vikas Pradhan, Salahuddin Salahuddin, Rajnish Kumar, Avijit Mazumder, Mohammad Mustaqeem Abdullah, Mohammad Shahar Yar, Mohamed Jawed Ahsan, Zabih Ullah
Summary: Cancer is a leading cause of death worldwide, posing substantial risks to society and individuals. Despite advances in cancer prevention, therapy remains challenging. Therefore, continuous research is being conducted to search for novel anticancer agents with broader cytotoxicity range. Quinoline derivatives, which are double ring structures of the heterocyclic aromatic nitrogen molecule formed by the fusion of a benzene ring and a pyridine ring at two carbon atoms close to each other, have been found to possess a wide range of pharmacological activities, including anticancer properties. Many quinoline derivatives are available as anticancer drugs, targeting various molecular mechanisms such as topoisomerase inhibition, tyrosine kinases inhibition, heat shock protein 90 (Hsp90) inhibition, histone deacetylases (HDACs) inhibition, cell cycle arrest and apoptosis inhibition, and tubulin polymerization inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Education, Scientific Disciplines
Pushkar Kumar Ray, Salahuddin, Avijit Mazumder, Rajnish Kumar, Mohamed Jawed Ahsan, Mohammad Shahar Yar
Summary: This research aims to design and synthesize novel compounds containing pyrazoline moiety with enhanced anticonvulsant activity. The compounds were docked against the active site of human mitochondrial branched-chain aminotransferase to investigate their potential. The study successfully synthesized a series of pyrazoline derivatives and identified compounds with potent anticonvulsant activity.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Md. Afroz Bakht, Thangaiyan Pooventhiran, Renjith Thomas, Mehnaz Kamal, Israf Ud Din, Najeeb Ur Rehman, Imtiaz Ali, Noushin Ajmal, Mohamed Jawed Ahsan
Summary: Phospholipase A2 (PLA2) promotes inflammation by releasing arachidonic acid (AA), and its elevated level is associated with various diseases. Inhibiting PLA2 can be a potential strategy for treating inflammation by blocking the AA cascade. An efficient method for synthesizing octahydroquinazolinone compounds has been developed, and two compounds show strong inhibitory effects against PLA2 and protease.
Article
Chemistry, Multidisciplinary
Km. Shabana, Salahuddin, Avijit Mazumder, Himanshu Singh, Rajnish Kumar, Sonakshi Tyagi, Vimal Datt, Abhishek Shankar Sharma, Mohammad Shahar Yar, Mohamed Jawed Ahsan, Ranjeet Kumar Yadav
Summary: This study synthesized a series of new quinoline-bearing amino acid-derived benzimidazole derivatives. These compounds showed potent anticonvulsant activity, similar to phenytoin and carbamazepine, by inhibiting voltage-gated sodium channels and NMDA receptors. The development of nitrogen-containing hybrid heterocyclic compounds has the potential to contribute to the discovery and development of new drugs with improved efficacy, selectivity, and safety profiles.
Review
Chemistry, Multidisciplinary
Vidya Jyothi Alli, Pawan Yadav, Vavilapalli Suresh, Surender Singh Jadav
Summary: WEE1 is a critical checkpoint kinase in mitotic events, playing a crucial role in cell maturation and DNA repair. In cancer cells, elevated levels of WEE1 kinase are often associated with progression and survival. Therefore, WEE1 kinase has emerged as a promising target for anticancer therapy. Various classes of WEE1 inhibitors have been designed using rational or structure-based techniques, and the discovery of AZD1775 has further strengthened the potential of WEE1 as an anticancer target.
Article
Chemistry, Physical
Mohamed Jawed Ahsan, Abuzer Ali, Amena Ali, Obaid Afzal, Salahuddin, Mohammad Yusuf, Abdulmalik Saleh Alfawaz Altamimi, Omprakash Sharma, Manal A. Alossaimi, Md Afroz Bakht
Summary: In this study, a class of biologically active compounds was synthesized and tested for antibacterial, antitubercular, and antifungal activities. One compound showed the best antibacterial activity, but lower activity against mycobacterium strains and fungal strains. Another compound displayed moderate antifungal activity. Furthermore, ADME and toxicity prediction, as well as molecular docking studies with bacterial DNA gyrase, were conducted on these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Amena Ali, Abuzer Ali, Vivek Asati, Savas Kaya, Mohamed Jawed Ahsan
Summary: This study synthesized a series of benzylidene-linked thia-zolidine-2,4-dione compounds and evaluated their potential antidiabetic properties. Among the compounds examined, compound 4c emerged as the most promising candidate, exhibiting the highest PPAR-gamma agonistic activity and demonstrating commendable in-vivo performance in lowering blood glucose levels. These findings highlight its potential as a potent protein inhibitor and open new avenues for the intelligent design of molecules with high efficacy in managing hyperglycemia.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Medicinal
Sonakshi Tyagi, Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Mohammad Shahar Yar, Mohamed Jawed Ahsan
Summary: Quinoline has recently gained importance in industrial and synthetic organic chemistry, due to its widespread applications. Quinoline derivatives have been used in clinical trials for various cancer-related medical conditions. This review focuses on recent progress in the synthesis of novel quinoline derivatives as potential anti-cancer agents, as well as their structure-activity relationship, providing valuable insights for future research and development.
MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Obaid Afzal, Amena Ali, Abuzer Ali, Abdulmalik Saleh Alfawaz Altamimi, Manal A. Alossaimi, Md Afroz Bakht, Mubarak A. Salahuddin, Mubarak A. Alamri, Md. Faiyaz Ahsan, Mohamed Jawed Ahsan, Ki-Young Kim, Rozangela Curi Pedrosa
Summary: We synthesized and evaluated a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues (6a-h) as potential anticancer and antibacterial agents. The compounds demonstrated significant anticancer activity against specific cancer cell lines and efficient binding to the active site of the target protein. 4-Chloro-2-((5-(4-nitrophenyl)-1,3,4oxadiazol-2-yl)amino)phenol (6c) showed the most promising antibacterial activity against both Gram-negative and Gram-positive bacteria.
Article
Biochemistry & Molecular Biology
Mohamed Jawed Ahsan, Krishna Gautam, Amena Ali, Abuzer Ali, Abdulmalik Saleh Alfawaz Altamimi, S. V. V. N. S. M. Salahuddin, Manal A. Alossaimi, S. V. V. N. S. M. Lakshmi, Md. Faiyaz Ahsan
Summary: In this study, the synthesis, characterization, anticancer activity, molecular docking studies, ADME, and toxicity prediction of ten new 5-(3-Bromophenyl)-N-aryl-4H-1,2,4-triazol-3-amine analogs were described. Some of the compounds demonstrated significant anticancer activity against certain cancer cell lines, with compound 4i showing the most promising results. The compounds also exhibited efficient binding affinities and low toxicity according to the ADME and toxicity prediction studies.
Article
Chemistry, Organic
Devleena Tiglani, Salahuddin, Avijit Mazumder, Rajnish Kumar, Mohammad Shahar Yar, Mohamed Jawed Ahsan, Km Shabana
Summary: Both benzimidazole and quinoline pharmacophores have shown diverse activities against various diseases. This research successfully synthesized novel derivatives combining these two nuclei and evaluated their anticonvulsant, antidepressant, and anticancer activities. The compounds showed promising results in inhibiting seizures in mice and inhibiting the growth of leukemia and renal cancer cells.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
