Article
Chemistry, Medicinal
Haochao Zhang, Liandong Jing, Man Liu, Masuo Goto, Fangfang Lai, Xiao Liu, Li Sheng, Yajun Yang, Ying Yang, Yan Li, Xiaoguang Chen, Kuo-Hsiung Lee, Zhiyan Xiao
Summary: Selective inhibition of CDK8 through a series of novel pyridine core inhibitors has shown significant antitumor activity in vitro, with some compounds inducing G2/M phase arrest in cancer cells. Preliminary studies also demonstrated moderate antitumor efficacy in mouse models, highlighting the potential of these compounds as selective CDK8 inhibitors for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
M. Korycka-Machala, M. Kawka, J. Lach, R. Plocinska, A. Bekier, B. Dziadek, A. Brzostek, P. Plocinski, D. Strapagiel, M. Szczesio, K. Gobis, J. Dziadek
Summary: Recently, it has been discovered that 4-substituted picolinohydrazonamides with hydrophilic cyclic amines exhibit potent antimycobacterial activity in vitro. Two selected compounds, 2,4-disubstituted pyridine derivatives 11 and 15, showed significant bactericidal activity against Mycobacterium tuberculosis within human macrophages and biofilm-forming tubercle bacilli.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Liguo Zhang, Litao Yu, Oi Lun Li, Si-Young Choi, Ghuzanfar Saeed, Damin Lee, Kwang Ho Kim
Summary: Uniform amorphous FePO4 nanospheres with a diameter of 220 nm are successfully synthesized by a simple hydrothermal process, showing good sodium-ion storage performances. The necessity of an amorphous structure for the sodium-ion battery system is highlighted, as it enables the transformation between amorphous and microcrystalline structures and contributes to the overall performance improvement.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Multidisciplinary Sciences
Shima Nasri, Mohammad Bayat, Fatemeh Rostami Miankooshki
Summary: A novel multi-component reaction was developed for the synthesis of diverse spiro-imidazo pyridine-indene derivatives. The reaction involved heterocyclic ketene aminals reacting with bindone, using malononitrile as a promoter or as one of the precursors. The convenient one-pot operation, high substrate diversity, and presence of active sites in the synthesized products are attractive features of this approach.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Emily C. Cherney, Liping Zhang, Weiwei Guo, Audris Huang, David Williams, Steven Seitz, Weifang Shan, Xiao Zhu, Johnni Gullo-Brown, Derrick Maley, Tai-an Lin, John T. Hunt, Christine Huang, Zheng Yang, Celia J. D'Arienzo, Lorell N. Discenza, Asoka Ranasinghe, Mary F. Grubb, Sarah C. Traeger, Xin Li, Kathy A. Johnston, Lisa Kopcho, Mark Fereshteh, Kimberly A. Foster, Kevin Stefanski, Diane Delpy, Gopal Dhar, Aravind Anandam, Sandeep Mahankali, Shweta Padmanabhan, Prabhakar Rajanna, Venkata Murali, T. Thanga Mariappan, Shabeerali Pattasseri, Roshan Y. Nimje, Zhenqiu Hong, James Kempson, Richard Rampulla, Arvind Mathur, Anuradha Gupta, Robert Borzilleri, Gregory Vite, Aaron Balog
Summary: IDO1 inhibitors have shown promise as immunotherapies for treating various cancers, and recent research has identified novel heme-displacing IDO1 inhibitors, including clinical molecules like linrodostat and BMS-986242. Through efforts to swap and optimize the quinoline component, a potent and selective IDO1 inhibitor with significant pharmacodynamic activity was discovered, showing potential for further development in cancer treatment.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Emanuele Moioli, Leo Schmid, Peter Wasserscheid, Hannsjoerg Freund
Summary: The kinetics of acid-catalyzed reactions of AAT and para to produce MEP was systematically studied, leading to the development of a reaction model based on experimental data. Full characterization of side products allowed for the description of the reactions as polymerization, highlighting the different reactivity of AAT and para. A kinetic model was developed using operando Raman spectroscopy, incorporating reactant concentration, temperature, and catalyst concentration to describe the formation of MEP and side products, paving the way for process intensification and evaluation of reaction routes.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Organic
Ghanshyam Jadhav, Vijay Medhane, Dattatray Deshmukh
Summary: This study describes an efficient and scalable synthesis of 2,4-diaryl substituted chromene [43-b] pyridine derivatives using a multicomponent reaction strategy by microwave irradiation. The synthetic strategy is found to be environmentally friendly, providing good yield and requiring a shorter reaction time.
LETTERS IN ORGANIC CHEMISTRY
(2021)
Article
Spectroscopy
Ramil F. Fatykhov, Ainur D. Sharapov, Ekaterina S. Starnovskaya, Yaroslav K. Shtaitz, Maria I. Savchuk, Dmitry S. Kopchuk, Igor L. Nikonov, Grigory V. Zyryanov, Igor A. Khalymbadzha, Oleg N. Chupakhin
Summary: A series of coumarin-pyridine push-pull fluorophores were successfully synthesized through direct C-H functionalization, with 4-alkylcoumarin pyridine derivatives showing good photoluminescence quantum yields, while 4-phenylcoumarin derivatives did not exhibit noticeable fluorescence. Detailed photophysical studies demonstrated the potential of combining different chromophore systems to enhance the properties of new fluorescent compounds.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Organic
Amelia Bou-Puerto, Delia Bellezza, Carlota Martinez-Morro, Nerea Gonzalez-Sanchis, Rafael Ballesteros, Ana C. Cunat, Rafael Ballesteros-Garrido
Summary: 6-Amino-7-azaindole was prepared by acceptorless dehydrogenative condensation of diaminopyridine and diols, and amino pyridines were also found to yield pyrrolo[3,2-b]pyrrole systems. These transformations were all performed with accessible heterogeneous catalysts: Pd/C and ZnO.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Zi-Xuan Wang, Bi-Jie Li
Summary: This study reports an amide-directed, regiodivergent, and enantioselective hydroalkynylation reaction. The regioselectivity can be tuned by choosing appropriate ligands, leading to the formation of products with acyclic tertiary or quaternary stereocenters beta to an amide. Furthermore, an asymmetric conjugated alkynylation reaction was achieved through a sequence of alkene isomerization and regioselective hydroalkynylation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Petra Kralova, Katerina Zakova, Lenka Pospisilova, Miroslav Soural
Summary: 2,3-Disubstituted quinoline-4-carbonitriles were synthesized through a series of reactions using various starting materials, and some of the prepared compounds showed moderate activity against E. coli.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Neetu Yadav, Kovuru Gopalaiah, Jyoti Pandey, Rajamani Nagarajan
Summary: In this study, the usage of inherent redox couplets in PrVO4 with a zircon-type structure for tandem oxidative transformation was investigated. Monophasic PrVO4 exhibited a tetragonal zircon-type structure and the existence of redox couplets Pr3+/Pr4+ and V4+/V5+ was confirmed. The catalytic utility of zircon PrVO4 for the one-pot synthesis of 2,3-disubstituted quinolines through the oxidative tandem reaction of 2-aminobenzylalcohols with 1,3-dicarbonyl compounds was demonstrated, achieving good to excellent yields.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Juan Carlos Lopez, Ibon Alkorta, Alberto Macario, Susana Blanco
Summary: This article investigates the structure and properties of complexes formed by pyridine and small ketones through experimental techniques and theoretical calculations.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Organic
Telmo N. Francisco, Joana L. C. Sousa, Samuel Guieu, Artur M. S. Silva, Helio M. T. Albuquerque
Summary: A mild synthesis of 3,5-disubstituted nitrobenzenes from readily available 3-formylchromones is reported. The developed methodology involves a cascade process catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene. The proposed mechanism includes Michael addition reactions and intramolecular cyclization, leading to the formation of three new C-C bonds. The method offers a straightforward and gram-scale synthesis of 3,5-disubstituted nitrobenzenes.
Article
Chemistry, Multidisciplinary
E. A. Dikusar, E. A. Akishina, S. K. Petkevich, N. A. Zhukouskaya, R. S. Alekseyev, N. A. Bumagin, S. N. Shahab, L. N. Filippovich, V. Potkin
Summary: A convenient one-step method was developed for the synthesis of new bisacridine derivatives, which contain fragments of 5-arylisoxazoles, 4,5-dichloroisothiazole, and isonicotinic acid residues covalently attached to the aromatic core by ester groups. The synthesized bisacridine compounds showed high catalytic activity in water.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Farahnaz K. Behbahani, Banafsheh Yazdanparast
ARABIAN JOURNAL OF CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Toktam Shiebani Daloee, Farahnaz K. Behbahani
MOLECULAR DIVERSITY
(2020)
Article
Chemistry, Organic
K. Arabpourian, F. K. Behbahani
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Organic
Fatemeh Karimirad, Farahnaz K. Behbahani
Summary: An efficient and green method for synthesizing 1,8-dioxo-decahydroacridines in high yields is presented, using glycerol as a promoter and avoiding the use of harmful organic solvents and catalysts based on transition metals under mild conditions. This method has been shown to produce four new derivatives of 1,8-dioxo-decahydroacridine, demonstrating its simplicity and environmental friendliness.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Review
Chemistry, Organic
Zahra Sadri, Farahnaz K. Behbahani
CURRENT ORGANIC SYNTHESIS
(2020)
Article
Chemistry, Organic
Maral Shekarchi, Farahnaz K. Behbahani
Summary: This study presented a method using a non-halogenated ionic liquid loaded on graphene oxide as a catalyst for synthesizing polysubstituted pyrroles under specific conditions. Starting from amines, benzaldehydes, or furfural, novel compounds were successfully synthesized, proving to be valuable for pharmaceutical research.
LETTERS IN ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Behzad Mohammadi, Farahnaz K. Behbahani, Gholam B. Marandi, Behrouz Mirza
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2020)
Article
Chemistry, Multidisciplinary
Maral Shekarchi, Farahnaz K. Behbahani, Maryam Shekarchi
Summary: The paper presents an effective procedure for the synthesis of 3-substituted indoles via a one-pot three-component reaction in ethanol, with the advantages of synthesizing novel compounds containing important nuclei and using non-halogenated ionic liquid.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Biochemistry & Molecular Biology
Roghayeh Ferdousian, Farahnaz K. Behbahani, Bita Mohtat
Summary: This research paper presents the synthesis and characterization of a magnetic nanoparticle catalyst, Fe3O4@Sal@Cu, which is green and retrievable. The catalyst was analyzed using FTIR, XRD, EDX, and TGA, and its catalytic activity in the synthesis of 2-amino 4H-chromenes was investigated. The catalyst showed good-to-excellent yields under mild reaction conditions and had the advantages of being eco-friendly, easy to handle, highly reusable, and magnetically separable.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Organic
Zahra Sadri, Farahnaz K. Behbahani, Elham Keshmirizadeh
Summary: In this study, a novel and reusable adenine-based nano magnetic catalyst Fe3O4@SiO2@(CH2)(3)NHCO-adenine sulfonic acid was designed and synthesized. The catalyst was characterized using various techniques and showed efficient catalytic performance in the synthesis of 2,3-dihydro-2-aryl-1H-perimidines. The catalyst also demonstrated high potential for recovery and reuse.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Zahra Sadri, Farahnaz K. Behbahani, Elham Keshmirizadeh
Summary: In this study, a nanomagnetic catalyst Fe3O4@SiO2@(CH2)(3)NHCO-adenine sulfonic acid was used for the synthesis of 2,6-diamino-4-arylpyridine-3,5-dicarbonitriles. The method showed simple and mild reaction conditions, easy preparation of the catalyst, and the ability to synthesize new compounds. The catalyst also demonstrated high recovery and reusability.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Roghayeh Ferdousian, Farahnaz K. Behbahani
Summary: This article reviews the application of green solvent alternatives in organoselenium chemistry. It includes the use of ionic liquids and deep eutectic solvents for the synthesis of seleno-functionalized molecules under mild reaction conditions, and the use of polyethylene glycol, glycerol, and ethanol as solvents and organoselenium compounds as starting materials for the preparation of ionic liquids. The preparation and application in organic synthesis, materials synthesis, ligand chemistry, and biologically relevant processes of organoselenium compounds are discussed.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Fatemeh Shokri, Farahnaz K. Behbahani
Summary: High isolated yields of N-substituted pyrroles can be obtained by reacting hexane-2,5-dione with amines in the presence of Fe3O4@L-proline@SO3H under ultrasonic irradiation at ambient temperature without solvent. Fair yields of pyrrole derivatives can also be achieved when reacting hexane-2,5-dione with amines containing electron-acceptor substituents, such as 4-nitroaniline.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Zahra Mirzaei, Farahnaz K. Behbahani
HETEROCYCLIC LETTERS
(2018)
Article
Chemistry, Organic
Maryam Azari, Farahnaz K. Behbahani
HETEROCYCLIC LETTERS
(2018)
