Article
Health Care Sciences & Services
Dorota Maria Borowicz, Konstantin N. Shipulin, Gennady V. Mytsin, Agnieszka Skrobala, Piotr Milecki, Victor N. Gayevsky
Summary: Comparison between passive scattering (PS) and intensity-modulated proton therapy (IMPT) for ultra-hypofractionated proton therapy in localized prostate cancer (PCa) showed that IMPT provided better target coverage and lower mean doses to the rectum and bladder compared to PS. However, PS had a slightly better performance in high dose distribution to the rectum. There were no significant differences in mean conformity index values and gamma index between the two treatment methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
Kishan J. Pithadia, Pragati G. Advani, Deborah E. Citrin, Justin E. Bekelman, Diana R. Withrow, Amy Berrington de Gonzalez, Lindsay M. Morton, Sara J. Schonfeld
Summary: A retrospective cohort study found that intensity-modulated radiotherapy (IMRT) for prostate cancer is not associated with an increased risk of second primary cancers. Any inverse associations may be correlated with the calendar year of treatment.
Article
Multidisciplinary Sciences
Jongmoo Park, Jaehyeon Park, Sean Oh, Ji Woon Yea, Jeong Eun Lee, Jae Won Park
Summary: The study compared the efficacy of VMAT plans with and without multi-criteria optimization (MCO), finding that the MCO plan improved gross treatment volume coverage, reduced maximal dose, and improved dose distribution quality. In terms of OAR sparing, the MCO plan performed better by sacrificing tolerable dose to bilateral femoral heads for better protection of the rectum and bladder.
Article
Oncology
Darren M. Zuro, Gabriel Vidal, James Nathan Cantrell, Yong Chen, Chunhui Han, Christina Henson, Salahuddin Ahmad, Susanta Hui, Imad Ali
Summary: The purpose of this study is to investigate the treatment planning of TMI using IMPT. The dosimetric parameters of IMPT plans were evaluated and compared with VMAT plans. The results showed significant reduction in organ-at-risk dose in IMPT plans compared to VMAT plans.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Elton Trigo Teixeira Leite, Clarissa Cerchi Angotti Ramos, Victor Augusto Bertotti Ribeiro, Bernardo Peres Salvajoli, William Carlos Nahas, Joao Victor Salvajoli, Fabio Ynoe Moraes
Summary: This study evaluated the safety and feasibility of postoperative hypofractionated radiation therapy to the prostate bed. The results showed acceptable genitourinary and gastrointestinal toxicity profiles in the short to medium term, but further long-term follow-up and large-scale randomized trials are still necessary.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Brady S. Laughlin, Alvin C. Silva, Sujay A. Vora, Sameer R. Keole, William W. Wong, Michael H. Schild, Steven E. Schild
Summary: This retrospective study demonstrated the long-term efficacy of treating prostate cancer using intensity modulated radiation therapy (IMRT) with the incorporation of MRI-guided boost. The results showed that MRI-guided localized dose intensification can provide high long-term disease control while maintaining favorable long-term toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Arya Amini, Rustain Morgan, Elisabeth Meyer, Kareem Fakhoury, Colton Ladbury, Thomas Bickett, Jessica D. McDermott, William Stokes, Sana D. Karam
Summary: The study found that patients with early stage glottic cancer receiving 3D-conformal radiation therapy (3D-CRT) had superior cancer-specific survival (CSS) compared to intensity-modulated radiation therapy (IMRT), but there was no difference in overall survival (OS).
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Heerim Nam, Yong Chan Ahn, Kyungmi Yang, Dongryul Oh, Jae Myoung Noh
Summary: This study analyzed the treatment outcomes of locally recurrent nasopharyngeal cancer patients following moderate hypo-fractionation re-irradiation. The results showed that the treatment was feasible and effective in treating locally recurrent NPC patients.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
James R. Janopaul-Naylor, Yichun Cao, Neal S. McCall, Jeffrey M. Switchenko, Sibo Tian, Haijian Chen, William A. Stokes, Aparna H. Kesarwala, Mark W. McDonald, Joseph W. Shelton, Jeffrey D. Bradley, Kristin A. Higgins
Summary: Definitive IMPT re-irradiation for lung cancer can prolong disease control with limited toxicity, particularly in the immunotherapy era.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Paul D. Brown, Caroline Chung, Diane D. Liu, Sarah McAvoy, David Grosshans, Karine Al Feghali, Anita Mahajan, Jing Li, Susan L. McGovern, Mary-Fran Mcaleer, Amol J. Ghia, Erik P. Sulman, Marta Penas-Prado, John F. de Groot, Amy B. Heimberger, Jihong Wang, Terri S. Armstrong, Mark R. Gilbert, Nandita Guha-Thakurta, Jeffrey S. Wefel
Summary: The study found that proton radiotherapy (PT) did not delay time to cognitive failure in patients with newly diagnosed gliobiastoma (GBM) compared to intensity-modulated radiotherapy (IMRT), but it reduced toxicity and patient-reported fatigue. PT significantly reduced the radiation dose for almost all structures analyzed. Larger randomized trials are needed to further explore the potential benefits of PT in GBM and cognitive preservation in patients with lower-grade gliomas.
Article
Oncology
Alan J. Sosa, Howard D. Thames, Jeremiah W. Sanders, Seungtaek L. Choi, Quynh-Nhu Nguyen, Henry Mok, X. Ron Zhu, Shalin Shah, Lauren L. Mayo, Karen E. Hoffman, Chad Tang, Andrew K. Lee, Thomas J. Pugh, Reena Kudchadker, Steven J. Frank
Summary: This study aimed to evaluate the long-term effectiveness and toxicity of proton therapy in patients with localized prostate cancer. The results showed excellent clinical outcomes of proton therapy in this large cohort, even among higher-risk groups with historically poor outcomes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Sota Nakahara, Takayuki Ohguri, Sho Kakinouchi, Hirohide Itamura, Takahiro Morisaki, Subaru Tani, Katuya Yahara, Naohiro Fujimoto
Summary: This study retrospectively analyzed the efficacy and toxicity of adding regional hyperthermia to intensity-modulated radiotherapy (IMRT) plus neoadjuvant androgen deprivation therapy (ADT) for high-risk localized prostate carcinoma. The results showed that adding hyperthermia improved clinical relapse-free survival and higher thermal dose predicted improved biochemical disease-free survival.
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Oncology
Dalia Ahmad Khalil, Joerg Wulff, Danny Jazmati, Dirk Geismar, Christian Baumer, Paul-Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleithoff, Stephan Tschirdewahn, Boris Hadaschik, Beate Timmermann
Summary: The aim of this study was to examine the dosimetric influence of endorectal balloons (ERB) on rectal sparing in prostate cancer patients with implanted hydrogel rectum spacers treated with dose-escalated or hypofractionated intensity-modulated proton beam therapy (IMPT). The results showed that ERB can reduce rectal volumes exposed to intermediate or low dose levels. However, there was no significant reduction in rectal volume in patients receiving high or intermediate doses. According to available NTCP models, there was no benefit or disadvantage associated with the use of ERB for late rectal toxicity.
Article
Oncology
Jordan A. Holmes, Anna K. Paulsson, Brandi R. Page, Lance D. Miller, Wennuan Liu, Jianfeng Xu, William H. Hinson, Glenn J. Lesser, Adrian W. Laxton, Stephen B. Tatter, Waldemar Debinski, Michael D. Chan
JOURNAL OF NEURO-ONCOLOGY
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Lian, Yeqin Shao, Larry D. Potter, Ronald C. Chen, Jordan A. Holmes, Eleanor A. Pryser, Jie Shen, Dinggang Shen, Andrew Z. Wang
Article
Oncology
Jordan A. Holmes, Andrew Z. Wang, Karen E. Hoffman, Laura H. Hendrix, Julian G. Rosenman, William R. Carpenter, Paul A. Godley, Ronald C. Chen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2012)
Article
Oncology
Anna K. Paulsson, Jordan A. Holmes, Ann M. Peiffer, Lance D. Miller, Wennuan Liu, Jianfeng Xu, William H. Hinson, Glenn J. Lesser, Adrian W. Laxton, Stephen B. Tatter, Waldemar Debinski, Michael D. Chan
JOURNAL OF NEURO-ONCOLOGY
(2014)
Article
Oncology
Kyle Wang, Kevin A. Pearlstein, Dominic H. Moon, Zahra M. Mahbooba, Allison M. Deal, Yue Wang, Stephanie R. Sutton, Britni B. Motley, Gregory D. Judy, Jordan A. Holmes, Nathan C. Sheets, Mohit S. Kasibhatla, Heather D. Pacholke, Colette J. Shen, Timothy M. Zagar, Lawrence B. Marks, Bhishamjit S. Chera
Review
Oncology
Ethan M. Steele, Jordan A. Holmes
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2019)
Article
Oncology
Kyle Wang, Rachel Tobillo, Panayiotis Mavroidis, Ryan Pappafotis, Kevin A. Pearlstein, Dominic H. Moon, Zahra M. Mahbooba, Allison M. Deal, Jordan A. Holmes, Nathan C. Sheets, Mohit S. Kasibhatla, Heather D. Pacholke, Trevor J. Royce, Ashley A. Weiner, Colette J. Shen, Timothy M. Zagar, Lawrence B. Marks, Bhishamjit S. Chera
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Shearwood McClelland, Cristiana Hentea, Rong Fan, Todd E. Bertrand, Jordan A. Holmes
PEDIATRIC BLOOD & CANCER
(2020)
Article
Oncology
Christina Huang, Kevin Shiue, Greg Bartlett, Namita Agrawal, Mona Arbab, Peter Maxim, Colleen DesRosiers, Todd Mereniuk, Susannah Ellsworth, Ryan Rhome, Jordan Holmes, Mark Langer, Richard Zellars, Tim Lautenschlaeger
Article
Oncology
Samantha L. Freije, Jordan A. Holmes, Saleh Rachidi, Susannah G. Ellsworth, Richard C. Zellars, Tim Lautenschlaeger
Editorial Material
Oncology
Jordan A. Holmes, Constantinos Zamboglou, Ronald C. Chen
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Mona Arbab, Jordan A. Holmes, Kenneth R. Olivier, Emma C. Fields, Kimberly S. Corbin, Jenna M. Kahn, Richard C. Zellars, Antwione M. Haywood
Summary: This paper highlights the importance of cancer education in medical education and suggests incorporating oncology into undergraduate medical education to train future physicians.
ADVANCES IN RADIATION ONCOLOGY
(2021)
Review
Oncology
Shearwood McClelland, Flora Amy Achiko, Gregory K. Bartlett, Gordon A. Watson, Jordan A. Holmes, Ryan M. Rhome, Colleen M. DesRosiers, Karen M. Hutchins, Kevin Shiue, Namita Agrawal
Summary: In radiation oncology, virtual peer review can be performed with similar timeliness compared to in-person peer review. The overall deviation rate is significantly reduced in virtual peer review, indicating that further investigation is needed to determine if virtual workflow can be considered a standard of care.
ADVANCES IN RADIATION ONCOLOGY
(2021)
Article
Oncology
Jordan A. Holmes, Ronald C. Chen
JNCI CANCER SPECTRUM
(2018)
Article
Oncology
Jordan A. Holmes, Timothy M. Zagar, Ronald C. Chen
JNCI CANCER SPECTRUM
(2017)