Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates

(2015) Antoine Maruani et al.   CHEMICAL COMMUNICATIONS

Cysteine-Selective Reactions for Antibody Conjugation

(2014) Pedro M. S. D. Cal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

(2014) L. Nathan Tumey et al.   BIOCONJUGATE CHEMISTRY

Synthesis of Conjugated Oligonucleotide in Solution Phase Using Alkyl-chain-soluble Support

(2014) Takao Shoji et al.   CHEMISTRY LETTERS

Loss of PEG chain in routine SDS-PAGE analysis of PEG-maleimide modified protein

(2014) Chun Zhang et al.   ELECTROPHORESIS

Orthogonal Protection of Peptides and Peptoids for Cyclization by the Thiol–Ene Reaction and Conjugation

(2014) Xavier Elduque et al.   JOURNAL OF ORGANIC CHEMISTRY

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Protected Maleimide Building Blocks for the Decoration of Peptides, Peptoids, and Peptide Nucleic Acids

(2013) Xavier Elduque et al.   BIOCONJUGATE CHEMISTRY

A New Reagent for Stable Thiol-Specific Conjugation

(2013) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

(2013) Pavel Strop et al.   CHEMISTRY & BIOLOGY

Straightforward Synthesis of Cyclic and Bicyclic Peptides

(2013) Xavier Elduque et al.   ORGANIC LETTERS

Antibody–drug conjugates:

(2013) Stephen Ornes   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conjugation Reactions Involving Maleimides and Phosphorothioate Oligonucleotides

(2012) Albert Sánchez et al.   BIOCONJUGATE CHEMISTRY

Oligonucleotidecyclization: the thiol-maleimide reaction revisited

(2012) Albert Sánchez et al.   CHEMICAL COMMUNICATIONS

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes

(2012) Albert Sánchez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

Maleimide-DimethylfuranexoAdducts: Effective Maleimide Protection in the Synthesis of Oligonucleotide Conjugates

(2011) Albert Sánchez et al.   ORGANIC LETTERS

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

(2008) Stephen C. Alley et al.   BIOCONJUGATE CHEMISTRY