期刊
MOLECULES
卷 20, 期 4, 页码 6959-6969出版社
MDPI AG
DOI: 10.3390/molecules20046959
关键词
nitrones; aqueous Kinugasa reaction; -lactams; bioorthogonal; metabolic labelling
资金
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- NSERC
The Kinugasa reaction has become an efficient method for the direct synthesis of -lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with micelle-promoted [3+2] cycloadditions followed by rearrangement furnishing high yields of -lactams. The high yields of stable products under aqueous conditions render the modified Kinugasa reaction amenable to metabolic labelling and bioorthogonal applications. Herein, the development of methods for use of the Kinugasa reaction in aqueous media is reviewed, with emphasis on its potential use as a bioorthogonal coupling strategy.
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