Review
Clinical Neurology
Marissa J. Luft, Eric T. Dobson, Amir Levine, Paul E. Croarkin, Jeffrey R. Strawn
Summary: The study conducted a systematic review and Bayesian network meta-analysis to compare interventions for antidepressant-induced sexual dysfunction in adults. The results showed that sildenafil may ameliorate antidepressant-induced sexual dysfunction, but more randomized controlled trials are needed to examine the effectiveness of other interventions.
Article
Plant Sciences
Asad Ur Rahman, Fiaz Alam, Zia Ur Rehman, Muhammad Khan, Tawseef Ahmad
Summary: The effects of Mirabilis jalapa L. root extract on paroxetine-induced sexual dysfunction in male rats were investigated. The results showed that treatment with 300 mg/kg M. jalapa extract significantly increased sexual activity and frequencies of mount, intromission, and ejaculation in male rats. The analysis also identified several biologically active constituents in M. jalapa root extract. This study confirmed the strong aphrodisiac effect of M. jalapa root extract on paroxetine-induced sexually depressed male rats.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Multidisciplinary Sciences
Jason M. Cota, Taylor M. Benavides, John D. Fields, Nathan Jansen, Anuradha Ganesan, Rhonda E. Colombo, Jason M. Blaylock, Ryan C. Maves, Brian K. Agan, Jason F. Okulicz
Summary: The study investigated the prevalence of PDE-5-mediated DDIs in males with HIV receiving ART, finding that the majority of patients had potential drug interactions, especially in those on RTV- or COBI-boosted ART. The study highlights the importance of assessing for DDIs among individuals on ART, particularly those on boosted regimens.
Review
Optics
Farzad Salehpour, Mahsa Khademi, Farzan Vahedifard, Paolo Cassano
Summary: Sexual dysfunction is often seen in patients with depression, and there is a bidirectional relationship between the two conditions. Different types of sexual dysfunction may manifest differently in untreated and treated depressed patients. Neuropsychiatric medications, such as antidepressants, may cause sexual dysfunction. Photobiomodulation therapy can be used to treat sexual dysfunction and has beneficial physiological effects.
Article
Chemistry, Physical
Silvia Giatti, Alessandro Di Domizio, Silvia Diviccaro, Lucia Cioffi, Iacopo Marmorini, Eva Falvo, Donatella Caruso, Alessandro Contini, Roberto Cosimo Melcangi
Summary: Paroxetine, a widely used antidepressant, has been found to inhibit an enzyme called phenylethanolamine N-methyltransferase (PNMT), involved in the production of epinephrine. Altered levels of epinephrine have been associated with sexual dysfunction, which is a common side effect of antidepressant use. This study suggests a possible role of PNMT in the sexual dysfunction reported by antidepressant users.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Oncology
Bartlomiej Salata, Agnieszka Kluczna, Tomasz Dzierzanowski
Summary: Sexual disorders are common in cancer patients and often overlooked. Opioid drugs play a major role in causing sexual dysfunction, although the exact mechanisms are still being studied. Treatment options are limited and should be personalized based on the underlying pathology.
Article
Medicine, General & Internal
Yu Chen, Hong-Chiang Chang, William J. J. Huang, Chii-Jye Wang, Thomas I-Sheng Hwang, Chun-Hou Liao, Chia-Chu Liu, See-Tong Pang, Eric Yi-Hsiu Huang, Chih-Wei Tsao, Kuo-Chiang Chen, Shih-Ping Liu, Chao-Yuan Huang, Cheng-Hsing Hsieh, Bang-Ping Jiann
Summary: According to the Taiwan Cancer Report, prostate cancer was one of the top five cancers reported in men in 2018. Erectile dysfunction is a common complication of radical prostatectomy therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Andrology
Jason L. Lui, Nathan M. Shaw, Behzad Abbasi, Nizar Hakam, Benjamin N. Breyer
Summary: This study investigated the safety profile of oral phosphodiesterase type 5 inhibitors, revealing common adverse drug reactions such as poor drug efficacy, headache, abnormal vision, flushing, and dyspepsia. The study also found a correlation between the use of these inhibitors and an increased risk of malignant melanoma.
Review
Urology & Nephrology
Gal Saffati, Taher Naeem, Maya Guhan, Alejandro Abello, David Eugenio Hinojosa-Gonzalez, Basil Kaaki, Blair T. Stocks, Larry Lipshultz, Mohit Khera
Summary: This study reviewed and meta-analyzed available data on the use of hyperbaric oxygen therapy (HBOT) for erectile dysfunction (ED), investigating its potential mechanisms of action and effectiveness. The results showed that HBOT appears to be a promising approach, particularly in men with vasculogenic ED.
SEXUAL MEDICINE REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Ralph Catalano, Sidra Goldman-Mellor, Tim A. Bruckner, Terry Hartig
Summary: The theory that sexual intimacy promotes mental health is widely accepted, but experimental evidence is lacking. Epidemiological approaches could provide more convincing evidence, but epidemiologists have paid little attention to this theory. The study found a decrease in suicide rates among middle-aged men, possibly linked to the reinforcement of mental health through sexual intimacy.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Andrology
Solomon Hayon, Evan J. Panken, Nelson E. Bennett
Summary: Low-intensity shockwave therapy (LiSWT) is gaining popularity for the treatment of erectile dysfunction (ED). Current studies show that LiSWT has low risk and positive improvements in erectile function. However, there is still debate over its clinical utility and optimal treatment protocol.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Pharmacology & Pharmacy
Joan Winter, Kimberly Curtis, Bo Hu, Anita H. Clayton
Summary: Sexual dysfunction is a common symptom in approximately 70% of patients with major depressive disorder. Antidepressant medications and adjunctive treatments can contribute to sexual dysfunction, making evaluation and treatment complex.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Andy C. Huang, Ta-Chuan Yeh, Nien-Chin Wu, Chien-Yu Yeh, Pei-Hua Lin, Kuei-Ying Yeh
Summary: This study investigated the effects of Epigallocatechin gallate (EGCG) on male sexual behavior in diabetic rats. The results showed that EGCG improved sexual function and lowered blood glucose levels in diabetic rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Abhinandan D. Hudwekar, Pankul Kotwal, Mohd. Ishaq Dar, Shilpi Balgotra, Ashish Dogra, Jaspreet Kour, Santosh S. Chobe, Utpal Nandi, Sajad Hussain Syed, Sanghapal D. Sawant
Summary: Continuing our research on sildenafil analogs as inhibitors of PDE5 for erectile dysfunction, we found that modifications at the N-methylpiperazine ring with hydrophobic region followed by hydrogen bond donor or acceptor region have potential. However, previously identified leads had limitations such as poor pharmacokinetic profile, low aqueous solubility, and poor bioavailability. Therefore, we designed, synthesized, and screened a new series of sildenafil based analogs. Compound 18 showed excellent in vitro activity with selectivity towards PDE5 isozyme, as well as excellent in vivo activity and pharmacokinetic profile. The compound also exhibited excellent cyp inhibition and CaCO2 permeability.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Plant Sciences
A. Anand Ganapathy, V. M. Hari Priya, Alaganandam Kumaran
Summary: This paper reviewed 97 medicinal plants with PDE5 inhibitory effect, of which 77 were selected based on their traditional use as aphrodisiacs. Isoflavones and biflavones were identified as the major active constituents responsible for action, while Icariin and Icariside II were found to be the most effective inhibitors from natural sources. Traditional medicines containing extracts of Ginkgo biloba, Kaempferia parviflora, Clerodendrum colebrookianum, Eurycoma longifolia, and Vitis vinifera were also found to inhibit the PDE5 enzyme.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)