期刊
MOLECULES
卷 20, 期 8, 页码 15192-15201出版社
MDPI
DOI: 10.3390/molecules200815192
关键词
Rehmannia glutinosa; ionone glycoside; rhemaneolignans; the protective effects of cardiomyocytes
资金
- Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-Year Plan Period [2011BAI06B02]
- Collaborative Innovation Center of Diagnosis, Treatment and Drug Research for Respiratory Disease, Henan province, China
A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity.
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