期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 66, 期 1, 页码 90-95出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000000112
关键词
epidemiology; HIV; fratures; bone; osteoporosis; electronic health records
资金
- A.P. Moller Foundation (Fonden til Laegevidenskabens Fremme)
- Danish Medical Research Council [22-04-0495]
- Oxford NIHR Musculoskeletal Biomedical Research Unit
- IDIAP Jordi Gol
- RETICEF (FEDER), Instituto de Salud Carlos III, Government of Spain
- Medical Research Council [MC_UU_12011/1, U1475000001, MC_UP_A620_1014] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, NF-SI-0508-10082] Funding Source: researchfish
Background: Different studies have reported an association between HIV infection, antiretroviral therapies, and impaired bone metabolism, but data on their impact on fracture risk are scarce. We studied the association between a clinical diagnosis of HIV infection and fracture risk. Methods: We conducted a case-control study using data from the Danish National Health Service registries, including 124,655 fracture cases and 373,962 age-and gender-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results: A total of 50 (0.40/1000) patients in the fracture group and 52 (0.14/1000) controls had an HIV diagnosis. The risk of any fracture was thus significantly increased among HIV-infected patients (age- and gender-matched OR = 2.89, 95% CI: 1.99 to 4.18). Similarly, significant increases in the risk of hip (OR = 8.99, 95% CI: 1.39 to 58.0), forearm (OR = 3.50, 95% CI: 1.26 to 9.72), and spine fractures (OR = 9.00, 95% CI: 1.39 to 58.1) were observed. Conclusions: HIV infection is associated with an almost 3-fold increase in fracture risk compared with that of age-and gender-matched uninfected patients. HIV patients are also at an almost 9-fold higher risk of hip fracture.
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