Article
Infectious Diseases
Minh Patrick Le, Lucile Pencole, Gilles Peytavin, Florian Bouchet-Crivat, Laurent Mandelbrot
Summary: In this study, it was found that doravirine crosses the placenta and accumulates within it, potentially providing a prophylaxis for vertical HIV transmission. Further investigation is needed to determine the safety and efficacy of this new antiretroviral agent in pregnancy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Chemistry, Medicinal
Wensheng Yu, Jian Liu, Dane Clausen, Younong Yu, Joseph L. Duffy, Ming Wang, Shouning Xu, Lin Deng, Takao Suzuki, Christine C. Chung, Robert W. Myers, Daniel J. Klein, James Fells, M. Katharine Holloway, Jin Wu, Guoxin Wu, Bonnie J. Howell, Richard J. O. Barnard, Joseph Kozlowski
Summary: The discovery of histone deacetylase (HDACs) 1, 2, and 3 inhibitors with ethyl ketone as the zinc-binding group is described. These inhibitors exhibit good enzymatic and cellular activity, high selectivity against hERG, minimized serum shift in cellular potency, and improved selectivity over HDACs 6 and 8. They contain a variety of substituted heterocycles on the imidazole or oxazole scaffold, with compounds 31 and 48 standing out for their potency, selectivity, reduced hERG activity, optimized serum shift, and good PK profiles in rats and dogs.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Infectious Diseases
Nokuzola Mbhele, Benjamin Chimukangara, Michelle Gordon
Summary: Antiretroviral therapy is crucial in controlling the HIV epidemic, with integrase strand transfer inhibitors (INSTIs) becoming more common. INSTIs have a higher genetic barrier to resistance, with DTG showing even higher resistance barriers and CAB being used as the first long-acting agent in HIV-1 treatment.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Pharmacology & Pharmacy
Caroline S. Foo, Rana Abdelnabi, Suzanne J. F. Kaptein, Xin Zhang, Sebastiaan ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K. Chatterjee, Pieter P. Annaert, Patrick F. Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts
Summary: Nelfinavir, an HIV protease inhibitor, shows antiviral activity against SARS-CoV-2 and can improve lung pathology induced by the virus in hamsters. It enhances the number and functionality of neutrophils and promotes their migration. Another combination of HIV protease inhibitors, Lopinavir/Ritonavir, also has a similar protective effect in this model.
ANTIVIRAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ruxandra-Cristina Marin, Tapan Behl, Nicoleta Negrut, Simona Bungau
Summary: Management of antiretroviral therapy in HIV+ patients faces challenges in improving patient adherence by selecting appropriate treatment regimens to reduce viremia, enhance immune response, and minimize adverse reactions. The use of protease inhibitor darunavir with enzyme inhibitors cobicistat or ritonavir has shown effectiveness in reducing HIV mortality and morbidity by impacting drug interactions and pharmacokinetics.
Article
Infectious Diseases
Laurent Mandelbrot, Roland Tubiana, Pierre Frange, Gilles Peytavin, Jerome Le Chenadec, Ana Canestri, Philippe Morlat, Cecile Brunet-Cartier, Jeanne Sibiude, Delphine Peretti, Veronique Chambrin, Amelie Chabrol, Eida Bul, Caroline Simon-Toulza, Lucie Marchand, Christelle Paul, Sandrine Delmas, Veronique Avettand-Fenoel, Josiane Warszawski, Monogest Study Grp
Summary: This study evaluated a perinatal NRTI-sparing strategy to prevent perinatal HIV transmission. The primary objective was to determine the proportion of patients maintaining a viral load (VL) of <50 copies/mL on darunavir/ritonavir monotherapy without needing treatment intensification. The results showed that nearly 10% of cases required treatment intensification, limiting the widespread use of darunavir/ritonavir maintenance monotherapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Thibaut Gele, Antoine Cheret, Alicia Castro Gordon, Lionelle Nkam, Valerie Furlan, Coralie Pallier, Pierre-Hadrien Becker, Pilartxo Catalan, Cecile Goujard, Anne-Marie Taburet, Jacques Gasnault, Helene Gouget, Aurelie Barrail-Tran
Summary: This study aimed to determine the concentrations of bictegravir, emtricitabine and tenofovir in the cerebrospinal fluid of HIV patients with CNS impairment, finding low exposure of these drugs in the CSF. The results suggest caution should be exercised when using BIC/FTC/TAF as first-line treatment for HIV patients with HCI under the age of 51.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Boris Revollo, Laura Vinuela, Lorena de la Mora, Federico Garcia, Marc Noguera-Julian, Mariona Parera, Roger Paredes, Josep M. Llibre
Summary: This article reports a case of integrase resistance in a patient treated with co-formulated dolutegravir/lamivudine. It highlights the importance of carefully considering and monitoring drug-drug interactions, even when they are regarded as having a low potential.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Shangjiu Hu, Ling Ma, Biao Dong, Qi Shan, Jinming Zhou, Guoning Zhang, Minghua Wang, Shan Cen, Mei Zhu, Juxian Wang, Yucheng Wang
Summary: A new class of HIV-1 protease inhibitors with phenol derived P2 ligands and nitro or halogens in P2' ligands have been designed and synthesized. Compound 17d displays potent enzyme inhibitory activity and greater antiviral activity against the DRV-resistant variant than the wild type virus.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Paola Magro, Isabella Zanella, Marta Pescarolo, Francesco Castelli, Eugenia Quiros-Roldan
Summary: Despite the lack of clear benefits observed with Lopinavir/ritonavir (LPV/r) treatment for COVID-19, its efficacy against SARS-CoV-2 infection deserves further evaluation.
BIOMEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Philipp Adams, Virginie Fievez, Rafaela Schober, Mathieu Amand, Gilles Iserentant, Sofie Rutsaert, Geraldine Dessilly, Guido Vanham, Fanny Hedin, Antonio Cosma, Michel Moutschen, Linos Vandekerckhove, Carole Seguin-Devaux
Summary: CD32 may label highly activated/exhausted memory CD4(+) T-cell subsets that contain only a small proportion of the translation-competent reservoir.
Article
Medicine, Research & Experimental
Raju Subramanian, Jennifer Tang, Jim Zheng, Bing Lu, Kelly Wang, Stephen R. Yant, George J. Stepan, Andrew Mulato, Helen Yu, Scott Schroeder, Naveed Shaik, Renu Singh, Scott Wolckenhauer, Anne Chester, Winston C. Tse, Anna Chiu, Martin Rhee, Tomas Cihlar, William Rowe, Bill J. Smith
Summary: Lenacapavir is a potent and stable HIV-1 capsid inhibitor with long-acting pharmacokinetics in both animals and humans, making it suitable for the prevention and treatment of HIV-1.
MOLECULAR PHARMACEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Yiping Li, Qinjian Wang, Shu Liang, Chuanteng Feng, Hong Yang, Hang Yu, Dan Yuan, Shujuan Yang
Summary: This study found that a PI-based ART regimen is beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. Efforts should be made to detect HIV-1 drug resistance earlier and ensure timely adjustment to PI-based ART, maximizing the benefits of early switch treatment for these patients.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Microbiology
Chunfu Wang, Haichang Huang, Kirsten Mallon, Lourdes Valera, Kyle Parcella, Mark I. Cockett, John F. Kadow, Eric P. Gillis, Mark Krystal, Robert A. Fridell
Summary: GSK878 is a potent inhibitor of HIV-1 that binds to the CA hexamer. It shows high efficacy against HIV-1 and variants with diverse CA sequences. Mechanism studies reveal that GSK878 blocks early and late steps of HIV-1 replication, primarily through altered stability of the HIV-1 CA core.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shahid N. Khan, John D. Persons, Michel Guerrero, Tatiana Ilina, Masayuki Oda, Rieko Ishima
Summary: The V54A mutation in HIV-1 protease not only decreases inhibitor affinity but also restores catalytic activity, as studied through various spectroscopic and enzymatic assays.
Article
Infectious Diseases
Frieder Pfafflin, Daniel Wendisch, Roland Scherer, Linda Juergens, Gisele Godzick-Njomgang, Eva Tranter, Pinkus Tober-Lau, Miriam Songa Stegemann, Victor Max Corman, Florian Kurth, Dirk Schuermann
Summary: This study reports the clinical characteristics of the first confirmed monkeypox patients admitted to a center in Berlin. Among the patients, most were MSM who had engaged in condomless receptive anal intercourse prior to admission. The main complaint was severe anal pain, and investigations revealed proctitis and anal and rectal ulcers with detection of the monkeypox virus. These findings suggest that sexual transmission may play a role in the current outbreak.
Editorial Material
Critical Care Medicine
Jacopo Saccomanno, Eva Pappe, Miriam Dulce, Elena Madlung, Frieder Gabriel, Jan-Moritz Doehn, Dirk Schuermann, Martin Witzenrath, Ralf-Harto Huebner
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Environmental Sciences
Desiree Gutmann, Gerhard Scheuch, Timon Lehmkuhler, Laura -Sabine Herrlich, Anton Landeis, Martin Hutter, Christoph Stephan, Maria Vehreschild, Yascha Khodamoradi, Ann-Kathrin Gossmann, Florian King, Frederik Weis, Maximilian Weiss, Holger F. Rabenau, Juergen Graf, Helena Donath, Ralf Schubert, Stefan Zielen
Summary: This study compared exhaled aerosols in SARS-CoV-2 infected individuals and healthy controls. The results showed that respiratory aerosol concentrations were significantly higher in SARS-CoV-2 positive individuals, which helps to understand the spread and course of respiratory viral infections and detect highly infectious individuals.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Hortensia Alvarez, Amanda Mocroft, Lene Ryom, Bastian Neesgaard, Simon Edwards, Veronica Svedhem, Huldrych F. Guenthard, Robert Zangerle, Colette Smith, Antonella Castagna, Antonella d'Arminio Monforte, Ferdinand Wit, Melanie Stecher, Clara Lehman, Cristina Mussini, Eric Fontas, Eva Gonzalez, Jan-Christian Wasmuth, Anders Soennerborg, Stephane De Wit, Nikoloz Chkhartishvili, Christoph Stephan, Kathy Petoumenos, Nadine Jaschinski, Vani Vannappagari, Joel Gallant, Lital Young, Alain Volny Anne, Lauren Greenberg, Raquel Martin-Iguacel, Eva Poveda, Josep M. Llibre
Summary: High baseline HIV RNA levels and low baseline CD4 T-cell counts are associated with higher rates of viral blips, low-level viremia, and residual viremia in individuals treated with integrase inhibitors or specifically with dolutegravir-based regimens, suggesting an independent impact of these characteristics.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Nils Wetzstein, Thomas A. Kohl, Margo Diricks, Silvia Mas-Peiro, Tomas Holubec, Johanna Kessel, Christiana Graf, Benjamin Koch, Eva Herrmann, Maria J. G. T. Vehreschild, Michael Hogardt, Stefan Niemann, Christoph Stephan, Thomas A. Wichelhaus
Summary: This study aimed to investigate the clinical characteristics and outcome of HCU-associated Mycobacterium chimaera infections. The study found that these infections were characterized by high morbidity and mortality, as well as challenges in diagnosis and treatment. Reoperation was associated with better survival.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Summary: This study aimed to examine the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. The study used data from two observational cohorts of people living with HIV in Germany and found that the rates of a first AIDS event have continuously declined, and health outcomes depend on CD4 count, viral load, and age but not on transmission mode.
Article
Immunology
Adam Trickey, Caroline A. Sabin, Greer Burkholder, Heidi Crane, Antonella d'Arminio Monforte, Matthias Egger, M. John Gill, Sophie Grabar, Jodie L. Guest, Inma Jarrin, Fiona C. Lampe, Niels Obel, Juliana M. Reyes, Christoph Stephan, Timothy R. Sterling, Ramon Teira, Giota Touloumi, Jan-Christian Wasmuth, Ferdinand Wit, Linda Wittkop, Robert Zangerle, Michael J. Silverberg, Amy Justice, Jonathan A. C. Sterne
Summary: Life expectancy has increased for people with HIV on antiretroviral therapy (ART). Latest prognosis data show that the survival rate of adults with HIV who have been on ART for at least 1 year in Europe and North America is similar to that of the general population, regardless of the starting time of ART. However, individuals with low CD4 counts at the start of treatment have lower life expectancy, highlighting the importance of early diagnosis and sustained treatment of HIV.
Article
Infectious Diseases
Benjamin Schleenvoigt, Juliane Ankert, Grit Barten-Neiner, Florian Voit, Norbert Suttorp, Christoph Boesecke, Christian Hoffmann, Daiana Stolz, Mathias Pletz, Gernot Rohde, Martin Witzenrath, Marcus Panning, Andreas Essig, Jan Rupp, Olaf Degen, Christoph Stephan, M. Dreher
Summary: The objective of this study was to identify the pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH), and to compare it with a matched HIV negative group in order to reassess therapeutic strategies for PLWH. The study used various methods to identify pathogens, and found that pneumococci were the most common pathogen among both PLWH and controls. The mortality rate was higher for PLWH compared to controls.
Editorial Material
Infectious Diseases
Benjamin T. Schleenvoigt, Anne Moeser, Dragisa Mitic, Michael Baier, Christoph Stephan, Anna Pothmann
Article
Infectious Diseases
Johanna Kessel, Elif Goeymen, Timo Wolf, Nils Wetzstein, Claus Kuepper-Tetzel, Pia Behrens, Frauke Borgans, Uemniye Balaban, Michael Hogardt, Thomas A. Wichelhaus, Christoph Stephan
Summary: The clinical relevance of the mismatch between sputum smear microscopy and culture in patients with open pulmonary tuberculosis (opTB) was investigated in this study. The results show that a substantial number of patients who were de-isolated after 3 negative sputum smear microscopy tests still had positive culture results. Further investigation is needed to determine the infectivity of smear-negative and culturally-positive individuals on therapy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Infectious Diseases
Gerrit Kann, Hermann Juling, Valentina Ilievski, Gerrit Burger, Stephan Goettig, Christoph Stephan, Nils Wetzstein
Summary: A 24-year-old patient from Cameroon presented to our hospital with a foreign structure in her left eye. For the first time, fluorescent microscopy revealed motile microfilariae, and the diagnosis of loiasis was confirmed. Despite high levels of microfilaremia, eosinophilia only became evident after antiparasitic therapy was initiated.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Lauren Greenberg, Lene Ryom, Elzbieta Bakowska, Ferdinand C. Wit, Heiner C. L. Bucher, Dominique L. Braun, Andrew Phillips, Caroline Sabin, Antonella d'Arminio Monforte, Robert Zangerle, Colette Smith, Stephane De Wit, Fabrice Bonnet, Christian Pradier, Cristina Mussini, Camilla Muccini, Joerg J. Vehreschild, Jennifer Hoy, Veronica M. Svedhem, Jose M. Miro, Jan-Christian Wasmuth, Peter M. Reiss, Josep M. Llibre, Nikoloz Chkhartishvili, Christoph I. Stephan, Camilla Hatleberg, Bastian Neesgaard, Lars Peters, Nadine Jaschinski, Nikos Dedes, Elena Kuzovatova, Marc Van Der Valk, Marianna Menozzi, Clara Lehmann, Kathy Petoumenos, Harmony Garges, Jim Rooney, Lital D. Young, Jens D. Lundgren, Loveleen Bansi-Matharu, Amanda Mocroft, RESPOND D A D Study Grp
Summary: Cancer incidence rates remained stable overall from 2006 to 2021, but there were changes in the rates of specific types of cancer among people with HIV. AIDS-defining cancers and infection-related cancers decreased, while non-AIDS-defining cancers, smoking-related cancers, and BMI-related cancers increased. These findings emphasize the importance of prevention strategies for reducing the incidence of non-AIDS-defining cancers, smoking-related cancers, and BMI-related cancers.
Meeting Abstract
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Meeting Abstract
Infectious Diseases
Moti Ramgopal, Anson Warupa, Axel Baumgarten, Mezgebe Berhe, Anton Pozniak, Juan Manuel Tiraboschi, Christoph Stephan, Hailin Huang, Kristen Andreatta, Nathan Unger, Jason Hindman, Hal Martin, Jared Baeten, Olayemi Osiyemi