Article
Cell Biology
Rehana Hewavisenti, Angela L. Ferguson, Georgia Gasparini, Tomoki Ohashi, Asolina Braun, Thomas S. Watkins, John J. Miles, Michael Elliott, Frederic Sierro, Carl G. Feng, Warwick J. Britton, Thomas Gebhardt, Stuart Tangye, Umaimainthan Palendira
Summary: Resident Tregs in human lymphoid organs, particularly in tonsils, exhibit a highly suppressive phenotype with increased expression of CD39, ICOS, and CTLA-4 compared to Tregs in circulation or spleen. Functionally, resident Tregs effectively suppress T cell proliferation and share key features of T follicular helper cells. Spatial analysis reveals that resident Tregs are strategically localized at the border of the T-zone and B cell follicle, as well as within lymphocyte pockets enriched with resident memory T cells to maintain immune homeostasis at sites of recurrent inflammation.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Review
Immunology
Darya Malko, Tarek Elmzzahi, Marc Beyer
Summary: Treg cells play a crucial role in controlling autoimmunity, immune responses during infections and tumor development, and tissue homeostasis. This review highlights the recent findings on the differentiation and function of tissue Treg cells, emphasizing their importance in tissue maintenance, regeneration, and repair in various organs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Hongbo Ni, Yinghan Chen
Summary: Regulatory T cells (Tregs) play a significant role in suppressing excessive immune response and maintaining tissue homeostasis. This review focuses on the migration of Tregs to non-lymphoid tissues and their adaptation to tissue microenvironments through the development of tissue-specific chemokine receptors, transcription factors, and phenotypes. Tumor-infiltrating Tregs (Ti-Tregs) are crucial for tumor generation and immunotherapy resistance, and their phenotypes overlap with tissue-specific Tregs. Understanding the molecular mechanisms behind tissue-specific Tregs can provide insights into potential therapeutic targets and biomarkers for inflammatory diseases and cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Nhi Ngo Thi Phuong, Vittoria Palmieri, Alexandra Adamczyk, Robert Klopfleisch, Jost Langhorst, Wiebke Hansen, Astrid M. Westendorf, Eva Pastille
Summary: The IL-33/ST2 pathway plays a crucial protective role in colitis by modulating the numbers of ILC2 and Treg cells, highlighting its potential as a novel therapeutic target in inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shinichi Yamamoto, Ako Matsui, Masaki Ohyagi, Chie Kikutake, Yoshihiro Harada, Mana Iizuka-Koga, Mikita Suyama, Akihiko Yoshimura, Minako Ito
Summary: Regulatory T cells (Tregs) suppress immune responses and contribute to tissue repair by interacting with non-immune cells. In this study, a culture method was developed to generate Tregs with brain Treg characteristics in vitro. These induced brain Tregs (iB-Tregs) showed similar gene expression patterns as in vivo brain Tregs and could infiltrate into the brain more readily and alleviate pathological symptoms in Parkinson's disease models. This research contributes to understanding brain Treg development and suggests therapeutic potential for inflammatory brain diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Nardos Cheru, David A. Hafler, Tomokazu S. Sumida
Summary: Maintenance of peripheral tolerance by CD4(+)Foxp3(+) regulatory T cells is crucial for regulating autoreactive T cells. Dysfunction of Foxp3 leads to autoimmune diseases. Tregs not only maintain immune homeostasis, but also establish tissue microenvironment and homeostasis of non-lymphoid tissues. Tissue resident Tregs show unique profiles and interact with both immune and non-immune cells, exerting suppressive function and adopting to local microenvironment through bidirectional interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ryota Sakai, Minako Ito, Kyoko Komai, Mana Iizuka-Koga, Kazuhiko Matsuo, Takashi Nakayama, Osamu Yoshie, Koichi Amano, Hiroshi Nishimasu, Osamu Nureki, Masato Kubo, Akihiko Yoshimura
Summary: Tregs accumulation in the kidney is crucial for disease control, with GATA3 playing an important role in recruiting Tregs to the kidney. The experimental data suggest that PPAR gamma agonist enhances the accumulation of GATA3(+) Tregs in the kidney.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jingyong Li, Ni Xia, Dan Li, Shuang Wen, Shirui Qian, Yuzhi Lu, Muyang Gu, Tingting Tang, Jiao Jiao, Bingjie Lv, Shaofang Nie, Desheng Hu, Yuhua Liao, Xiangping Yang, Guoping Shi, Xiang Cheng
Summary: In this study, a special group of Tregs that potentially inhibit the progression of abdominal aortic aneurysms (AAA) were identified and characterized. These Tregs are mainly recruited from peripheral circulation and secrete trefoil factor 1 (Tff1) to regulate smooth muscle cell (SMC) survival. The findings suggest a tissue-specific phenotype and function of aortic Tregs, providing a promising approach for AAA prevention.
Article
Medicine, General & Internal
Laura Schaefer, Claudia M. Trujillo-Vargas, Firas S. Midani, Stephen C. Pflugfelder, Robert A. Britton, Cintia S. de Paiva
Summary: Sjogren syndrome (SS) is an autoimmune inflammatory disorder characterized by reduced secretory function in the eye and mouth. Dysbiosis of the intestinal microbiota in SS patients may impact ocular surface health and the development of regulatory T cells. Animal studies with germ-free mice colonized with SS patient microbiota showed increased corneal barrier disruption.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi
Summary: Tregs play a critical role in skin wound healing, helping to balance immune homeostasis and promote healthy wound repair. Understanding the function and mechanisms of Tregs is important for understanding wound pathologies and developing new treatment strategies.
MILITARY MEDICAL RESEARCH
(2023)
Article
Immunology
Claire Germain, Priyanka Devi-Marulkar, Samantha Knockaert, Jerome Biton, Helene Kaplon, Laila Letaief, Jeremy Goc, Agathe Seguin-Givelet, Dominique Gossot, Nicolas Girard, Pierre Validire, Marine Lefevre, Diane Damotte, Marco Alifano, Francois M. Lemoine, Keith E. Steele, Jean-Luc Teillaud, Scott A. Hammond, Marie-Caroline Dieu-Nosjean
Summary: The presence of high TLS-B cell density in NSCLC tumors is associated with better clinical outcomes and more specific CD4(+) T cell responses. High TLS-B cell density can counterbalance the negative impact of high Treg density on patient survival, suggesting a central role for B cells in determining protective T cell responses in NSCLC patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Alexis Yero, Tao Shi, Omar Farnos, Jean-Pierre Routy, Cecile Tremblay, Madeleine Durand, Christos Tsoukas, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Summary: Early ART initiation was found unable to control the levels of immunosuppressive Treg subsets and their gut migration potential, potentially leading to gut tissue fibrosis and HIV disease progression.
Article
Oncology
Sho Sato, Hirokazu Matsushita, Daisuke Shintani, Yukari Kobayashi, Nao Fujieda, Akira Yabuno, Tadaaki Nishikawa, Keiichi Fujiwara, Kazuhiro Kakimi, Kosei Hasegawa
Summary: This study investigated the immune-inhibitory networks of T cells in the tumor microenvironment of epithelial ovarian cancer patients. The results showed that high-grade serous carcinoma was associated with a high frequency of effector-type Tregs, and the increase in these effector-type Tregs was correlated with increased PD-1 expression on CD8(+) T cells.
Review
Cardiac & Cardiovascular Systems
Qiong Wang, Yurong Wang, Danyan Xu
Summary: This study reviewed the roles of CD4(+) T cell subsets Th17 cells and Tregs in regulating atherosclerosis, with a focus on the impact of IL-17 and IL-10 in disease progression. Imbalance between Th17 and Tregs was found to play a crucial role in atherosclerosis development.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Respiratory System
Rebekka Faber Thudium, Andreas Ronit, Shoaib Afzal, Yunus Colak, Julie Lyng Forman, Fernando Mendo, Fabian Chen, Vicente Estrada, Nagalingeswaran Kumarasamy, Borge G. Nordestgaard, Jens Lundgren, Jorgen Vestbo, Ken M. Kunisaki, Susanne Dam Nielsen
Summary: This study compared the decline in lung function between people living with HIV who receive antiretroviral therapy and matched controls, and found that well-treated PLWH have faster lung function decline than controls. Smoking seems to modify this association, suggesting that smoking may lead to more rapid lung function decline in PLWH than in controls.
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Marco Gelpi, Luanna Uchoa Karvig, Andreas Dehlbaek Knudsen, Edith Wolder Sorensen, Thomas Benfield, Shoaib Afzal, Susanne Dam Nielsen
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality in people with HIV. This study found that body mass index and central obesity were associated with incident hypertension in well-treated HIV patients, suggesting the importance of lifestyle changes and weight loss in preventing hypertension, rather than focusing solely on HIV-specific factors.
Article
Infectious Diseases
Moises Alberto Suarez-Zdunek, Sunil Kumar Saini, Christian Ross Pedersen, Sebastian Rask Hamm, Annemette Hald, Allan Rasmussen, Jens Georg Hillingso, Sine Reker Hadrup, Susanne Dam Nielsen
Summary: This study aims to explore the cellular immune response against CMV and VZV infections in liver transplant recipients and identify potential risk factors for infection. Through an epidemiological substudy and an immunological substudy, the incidence and clinical risk factors for CMV and VZV infections will be determined, and the frequency, T cell receptor sequences, and phenotypic characteristics of CMV- and VZV-specific T cells will be examined. The study has the potential to develop a prediction model and proof-of-concept for adoptive T cell therapy against CMV and VZV to reduce the burden and consequence of infections in liver transplant recipients.
BMC INFECTIOUS DISEASES
(2023)
Article
Hematology
Line Dam Heftdal, Sebastian Rask Hamm, Laura Perez-Alos, Johannes Roth Madsen, Jose Juan Almagro Armenteros, Kamille Fogh, Christoffer Cronwald Kronborg, Anders Pommer Vallentin, Rasmus Bo Hasselbalch, Dina Leth Moller, Cecilie Bo Hansen, Mia Pries-Heje, Anne Ortved Gang, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Erik Sorensen, Linda Hilsted, Henning Bundgaard, Kasper Iversen, Peter Garred, Susanne Dam Nielsen, Kirsten Gronbaek
Summary: The initial responses to COVID-19 vaccination are impaired in patients with blood cancers. This study examined the immune responses of patients with myeloid and lymphoid malignancies who received three or four doses of the BNT162b2 vaccine, compared to controls. Risk factors for humoral and cellular nonresponse one year after vaccination were also identified.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Biology
Flora Mikaeloff, Marco Gelpi, Rui Benfeitas, Andreas D. Knudsen, Beate Vestad, Julie Hogh, Johannes R. Hov, Thomas Benfield, Daniel Murray, Christian G. Giske, Adil Mardinoglu, Marius Troseid, Susanne D. Nielsen, Ujjwal Neogi, Niel Hens
Summary: Multiomics technologies were used to stratify and characterize the metabolic risk profile in people living with HIV (PWH) on antiretroviral therapy. Through network analysis and similarity network fusion (SNF), three groups of PWH were identified: healthy-like, mild at-risk, and severe at-risk. PWH in the severe at-risk group had a high incidence of metabolic syndrome and dysregulated metabolic traits, despite having higher CD4(+) T-cell counts. The microbiome profile differed between the healthy-like group and the at-risk groups, potentially contributing to systemic inflammation and cardiometabolic risk.
Article
Immunology
Andreas D. Knudsen, Andreas Fuchs, Thomas Benfield, Jan Gerstoft, Lars Kober, Marius Troseid, Klaus F. Kofoed, Susanne D. Nielsen
Summary: Almost half of virologically suppressed persons with human immunodeficiency virus had atherosclerosis, and 18% had obstructive coronary artery disease. Interleukin 6 was associated with coronary artery disease but adjusting for cardiovascular risk factors attenuated the association.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Mads-Holger B. Jacobsen, Andreas D. Knudsen, Thomas Benfield, Sisse R. Ostrowski, Shoaib Afzal, Edith W. Sorensen, Susanne D. Nielsen, Marco Gelpi
Summary: This study investigated the association between soluble CD40 ligand, soluble thrombomodulin, and syndecan-1 with metabolic syndrome in people with HIV, and their association with HIV-specific variables. The results indicated that high levels of soluble CD40 ligand were associated with an increased risk of metabolic syndrome.
Article
Infectious Diseases
Sebastian Rask Hamm, Sunil Kumar Saini, Annemette Hald, Anna V. Vaaben, Natasja Wulff Pedersen, Moises Alberto Suarez-Zdunek, Zitta Barrella Harboe, Helle Bruunsgaard, Isik Somuncu Johansen, Carsten Schade Larsen, Claus Bistrup, Henrik Birn, Soren Schwartz Sorensen, Sine Reker Hadrup, Susanne Dam Nielsen
Summary: This study aims to characterize the immune response to RZV vaccination in kidney transplant candidates and recipients. The study will provide new knowledge and potentially enhance preventive strategies against herpes zoster in a population at increased risk.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Louise Bering, Anne Vinggaard Christensen, Nina Marie Birk, Lau Caspar Thygesen, Henning Bundgaard, Thomas Benfield, Ulrikka Nygaard, Jesper Johannesen, Susanne Dam Nielsen, Selina Kikkenborg Berg
Summary: This nationwide matched cohort study investigated the association between SARS-CoV-2 infection and new-onset type 1 diabetes (T1D) in children and adolescents. The study found that the risk of new-onset T1D in children and adolescents was not significantly increased after SARS-CoV-2 infection within 6 months.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Immunology
Zitta Barrella Harboe, Annemette Hald, Christina Ekenberg, Neval Ete Wareham, Lene Fogt Lundbo, Jon Gitz Holler, Tavs Qvist, Sebastian Rask Hamm, Stephanie Bjerrum, Omid Rezahosseini, Paul Suno Krohn, Finn Gustafsson, Michael Perch, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study describes the experience of implementing a vaccination clinic targeting different organ transplantation in a transplantation center in Denmark. The study found a low proportion of documented recommended vaccinations before transplantation, with higher serological protection against measles, mumps, or rubella. Most candidates required multiple vaccinations, including some needing live attenuated vaccines.
Article
Multidisciplinary Sciences
Laura Perez-Alos, Cecilie Bo Hansen, Jose Juan Almagro Armenteros, Johannes Roth Madsen, Line Dam Heftdal, Rasmus Bo Hasselbalch, Mia Marie Pries-Heje, Rafael Bayarri-Olmos, Ida Jarlhelt, Sebastian Rask Hamm, Dina Leth Moller, Erik Sorensen, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Linda Maria Hilsted, Henning Bundgaard, Susanne Dam Nielsen, Kasper Karmark Iversen, Peter Garred
Summary: The complexity of immune responses to SARS-CoV-2 has increased over time, with diverse immune imprinting observed in vaccinated individuals. Our study found that both humoral and cellular responses were generally higher after SARS-CoV-2 infection compared to infection-naive individuals. Pre-vaccination viral exposure was crucial for achieving a robust IgA response. Lower IgG, IgA, and neutralizing antibody responses post-vaccination were associated with a significantly higher risk of reinfection and future Omicron infections. However, T-cell responses did not show the same association. Primary infection before Omicron and subsequent reinfection dampened the humoral and cellular responses compared to a primary Omicron infection, consistent with immune imprinting.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Line Dam Heftdal, Laura Perez-Alos, Rasmus Bo Hasselbalch, Cecilie Bo Hansen, Sebastian Rask Hamm, Dina Leth Moller, Mia Pries-Heje, Kamille Fogh, Jan Gerstoft, Kirsten Gronbaek, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Erik Sorensen, Linda Hilsted, Henning Bundgaard, Peter Garred, Kasper Iversen, Caroline Sabin, Susanne Dam Nielsen
Summary: This study investigated the long-term durability of humoral and cellular immune responses to the third dose of BNT162b2 in people with HIV and controls. The results showed that before the third dose, HIV patients had lower concentrations of SARS-CoV-2 antibodies compared to controls, but there were no differences in antibody concentrations between the two groups after four and eleven months of the third dose. Additionally, there were no differences in cellular immune response between the two groups four months after the third dose.
Article
Immunology
Omid Rezahosseini, Sebastian Rask Hamm, Line Dam Heftdal, Laura Perez-Alos, Dina Leth Moller, Michael Perch, Johannes Roth Madsen, Annemette Hald, Cecilie Bo Hansen, Jose Juan Almagro Armenteros, Mia Marie Pries-Heje, Rasmus Bo Hasselbalch, Kamille Fogh, Ruth Frikke-Schmidt, Linda Maria Hilsted, Erik Sorensen, Sisse Rye Ostrowski, Zitta Barrella Harboe, Kasper Iversen, Henning Bundgaard, Soren Schwartz Sorensen, Allan Rasmussen, Peter Garred, Susanne Dam Nielsen
Summary: We found that within 12 months after receiving at least three doses of the BNT162b2 vaccine, solid organ transplant (SOT) recipients had lower humoral and T-cell responses compared to controls, especially those without previous SARS-CoV-2 infection. However, SOT recipients with previous infection had comparable immune responses to controls.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Ida Jarlhelt, Laura Perez-Alos, Rafael Bayarri-Olmos, Cecilie Bo Hansen, Maria Skaalum Petersen, Pal Weihe, Jose Juan Almagro Armenteros, Johannes Roth Madsen, Jacob Pohl Stangerup Nielsen, Linda Maria Hilsted, Kasper Karmark Iversen, Henning Bundgaard, Susanne Dam Nielsen, Peter Garred
Summary: The prediction of durability of immunity against COVID-19 is crucial, and longitudinal studies are necessary for understanding the details of protective SARS-CoV-2 antibody responses. The study developed an ELISA test based on the N protein to distinguish between infection- and vaccine-induced immune responses.
MICROBIOLOGY SPECTRUM
(2023)
