期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 67, 期 5, 页码 514-518出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000000359
关键词
HIV; elite controllers; antiretroviral therapy; gut immunology; microbial translocation; serious non-AIDS conditions; inflammation
资金
- Ontario HIV Treatment Network [ROGB-G123]
- Canadian Institutes of Health Research/Canadian Digestive Health Foundation (CIHR/CDHF)
- CIHR (Emerging HIV Team Grant) [HET85518]
- Canadian Research Chair Program
- Intramural Research Program of the National Institutes of Allergy and Infectious Diseases, National Institute of Health
Elite controllers (ECs) maintain undetectable HIV viral loads without antiretroviral therapy (ART) but are at increased risk of serious non-AIDS conditions (SNA). We assessed the impact of ART in ECs on gut immune dysfunction and biomarkers predicting SNA (blood CD4/CD8 ratio, plasma IL-6, D-dimer levels). At baseline, ECs had elevated IL-6 and D-dimer levels and reduced CD4/CD8 ratio compared with HIV-uninfected controls, but no difference in microbial translocation or gut CD4 subsets. ART increased CD4/CD8 ratio but did not normalize IL-6 and D-dimer levels. EC SNA pathogenesis may be independent of gut immune dysfunction, and resolution may require prolonged ART.
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