Article
Pediatrics
Armando B. D. Djiyou, Calixte Ida Penda, Yoann Madec, Grace Dalle Ngondi, Astrid Moukoko, Marie Varloteaux, Laure-Amelie de Monteynard, Cecile Moins, Carole Else Eboumbou Moukoko, Avelin F. Aghokeng
Summary: This study assessed the rate of sustained viral suppression (VS) and factors associated with virological failure (VF) in a cohort of adolescents receiving antiretroviral therapy (ART) in Cameroon. The study found a high rate of VS, indicating that achieving the UNAIDS 95% VS rate is feasible in this population.
Article
Public, Environmental & Occupational Health
Chao Zhou, Wei Zhang, Rongrong Lu, Lin Ouyang, Hui Xing, Yiming Shao, Guohui Wu, Yuhua Ruan
Summary: This study aimed to evaluate the impact of high baseline viral load (VL) on antiretroviral therapy (ART) outcomes among HIV-infected patients. The findings suggest that patients with high VL at ART initiation have a significantly higher risk of AIDS-related death and virologic failure. Therefore, optimizing the treatment regimen and initiating ART early may effectively reduce mortality among patients with a high baseline VL.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Eleanor A. Ochodo, Easter Elizabeth Olwanda, Jonathan J. Deeks, Sue Mallett
Summary: This study evaluated the diagnostic accuracy of point-of-care (POC) tests in detecting high viral load levels in people living with HIV (PLHIV). The results showed that POC tests have high sensitivity and specificity for diagnosing high HIV viral load in PLHIV attending healthcare facilities at a clinical threshold of >= 1000 copies/mL.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Jorge Saz, Albert Dalmau-Bueno, Michael Meulbroek, Ferran Pujol, Josep Coll, Angel Herraiz-Tomey, Felix Perez, Giovanni Marazzi, Hector Taboada, Dante R. Culqui, Joan A. Cayla
Summary: The use of fourth-generation rapid diagnostic tests in identifying acute HIV infection is effective in early diagnosis and treatment, with regular repeat testing for those who test negative. The study showed a positivity rate of 3.32% among 27,298 rapid tests, with high viral loads detected in the p24 antigen group, initiating treatment promptly on the following working day.
Article
Infectious Diseases
Gezahegn Terefe Atnafu, Nurilign Abebe Moges, Moges Wubie, Getnet Gedif
Summary: This study examined the viral load suppression rate after enhanced adherence counseling among HIV-positive adults in high caseload health facilities in the Amhara region, Ethiopia. The findings showed that approximately 51.73% of patients achieved viral load suppression after counseling, indicating a gap from the World Health Organization's target.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Virology
Monday Tola, Ramadhani O. Habib, Adebajo Sylvia, Trevor A. Crowell, Nowak G. Rebecca, Manhattan E. Charurat, Patrick Dakum, Nicaise Ndembi
Summary: In resource-limited settings, dried blood spots (DBS) may be a practical alternative to plasma for monitoring viral load in people living with HIV receiving antiretroviral therapy (ART). Results from DBS showed strong correlation with standard plasma viral load testing, indicating their potential usefulness in settings such as Nigeria.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Margaret M. Paschen-Wolff, Aimee N. C. Campbell, Susan Tross, Tse-Hwei Choo, Martina Pavlicova, Sarah Braunstein, Rachael Lazar, Christine Borges, Michael Castro, Hayley Berg, Graham Harriman, Robert H. Remien, Don Des Jarlais
Summary: Older age, opioid and stimulant use disorder were significantly associated with lower odds of durable viral suppression, while fulltime employment and stable housing were significantly associated with higher odds of durable viral suppression.
Article
Clinical Neurology
Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C. Guanizo, Gemma S. Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J. Gartner, Trisha A. Jenkins, Paul R. Gorry, Bruce J. Brew, Sharon R. Lewin, Jacob D. Estes, Michael Roche, Melissa J. Churchill
Summary: This study provides the first quantitative assessment of intact and defective HIV reservoirs in the brains of people with HIV. Despite antiretroviral therapy, HIV persists in the CNS, with similar levels of viral reservoirs in the brain and lymphoid tissue. Importantly, CNS resident CD68+ myeloid cells in virally suppressed individuals were found to harbor HIV DNA, indicating the presence of a CNS resident HIV reservoir.
ANNALS OF NEUROLOGY
(2022)
Article
Microbiology
Adolfo Vubil, Ana Flora Zicai, Nadia Sitoe, Carina Nhachigule, Paulino da Costa, Cacildo Magul, Bindiya Meggi, Sofia Viegas, Nedio Mabunda, Ilesh Jani, Yongjun Sui
Summary: In evaluating antiretroviral therapy failure, Burnett performed better than DBS, while HemaSpot performed worse than DBS. However, both devices have a high rate of non-reportable results.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Owen Ngalamika, Marie Claire Mukasine, Musonda Kawimbe, Faheema Vally
Summary: The study found that plasma levels of IL-5, IL-6, and IP-10 are associated with recurrence of HIV-associated KS, while persistently detectable HIV viral loads increase the risk of KS recurrence.
Article
Immunology
Thessa Laeremans, Sigrid D'haese, Jonathan Aernout, Kurt Barbe, Pieter Pannus, Sofie Rutsaert, Ellen Vancutsem, Guido Vanham, Coca Necsoi, Ward De Spiegelaere, Marie Couttenye, Natacha Herssens, Marie-Angelique De Scheerder, Stephane De Wit, Linos Vandekerckhove, Eric Florence, Joeri L. Aerts, Sabine D. Allard
Summary: This study investigates the use of qualitative plasma viral load (pVL) measurements to estimate viral reservoir size. The results show a positive correlation between t-DNA and the qualitative pVL measurements. Patients with a smaller viral reservoir have significantly lower qualitative pVL measurements. The study also suggests that t-DNA can be detected whenever the qualitative pVL measurements are higher than 56%.
Article
Computer Science, Interdisciplinary Applications
Manoj Kumar, Syed Abbas
Summary: This study focuses on an age-structured population model describing the dynamics of HIV/AIDS in the host. The stability of the infection-free steady state is checked using steady-state solutions and a Lyapunov function. The role of anti-retroviral therapy in slowing down HIV progression is also investigated.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2022)
Article
Medicine, Research & Experimental
Bingfeng Liu, Wanying Zhang, Baijin Xia, Shuliang Jing, Yingying Du, Fan Zou, Rong Li, Lijuan Lu, Shaozhen Chen, Yonghong Li, Qifei Hu, Yingtong Lin, Yiwen Zhang, Zhangping He, Xu Zhang, Xiejie Chen, Tao Peng, Xiaoping Tang, Weiping Cai, Ting Pan, Linghua Li, Hui Zhang
Summary: This study investigated the safety and antiviral activity of bNAb-derived CAR T cell therapy in individuals infected with HIV-1 undergoing analytical interruption of antiretroviral therapy. The therapy was found to be safe and effective, reducing viral reservoir, but rebound was due to viral escape mutations.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Laura N. Broyles, Robert Luo, Debi Boeras, Lara Vojnov
Summary: This article summarizes the risk of sexual transmission of HIV from individuals with low-level viral loads and emphasizes its importance in public health. The review of 8 studies shows that the risk of HIV transmission is almost zero when viral loads are below 1000 copies per mL. These findings can help destigmatize HIV and promote adherence to antiretroviral therapy.
Article
Immunology
Faeezah Patel, Stephanie Shiau, Renate Strehlau, Yanhan Shen, Megan Burke, Maria Paximadis, Sharon Shalekoff, Diana Schramm, Karl-Gunter Technau, Gayle G. Sherman, Ashraf Coovadia, Caroline T. Tiemessen, Elaine J. Abrams, Louise Kuhn
Summary: In a setting with high coverage of maternal ART and infant prophylaxis, factors such as maternal viral load and CD4+ T-cell counts were found to influence pre-ART viral load and CD4+T-cell parameters of infants diagnosed with HIV at birth.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Infectious Diseases
A. Duvignaud, M. Doutchi, C. Abejegah, I Etafo, M. Jaspard, B. Serra, E. Tricaud, C. Levy-Marchal, X. Anglaret, L. A. Ahmed, A. N. Adedosu, D. Malvy, O. O. Ayodeji
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Medicine, General & Internal
Francois-Xavier Blanc, Anani D. Badje, Maryline Bonnet, Delphine Gabillard, Eugene Messou, Conrad Muzoora, Sovannarith Samreth, Bang D. Nguyen, Laurence Borand, Anais Domergue, Delphine Rapoud, Naome Natukunda, Sopheak Thai, Sylvain Juchet, Serge P. Eholie, Stephen D. Lawn, Serge K. Domoua, Xavier Anglaret, Didier Laureillard
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Medicine, General & Internal
Jean Baptiste N'takpe, Delphine Gabillard, Raoul Moh, Elise Gardiennet, Arlette Emieme, Anani Badje, Gerard M. Kouame, Thomas-d'Aquin Toni, Sophie Karcher, Jerome Le Carrou, Herve Menan, Christine Danel, Serge P. Eholie, Christine Rouzioux, Xavier Anglaret
Article
Immunology
Roseline Affi, Delphine Gabillard, Catherine Dunyach-Remy, Jean-Baptiste Ntakpe, Raoul Moh, Anani Badje, Gerard M. Kouame, Sophie Karcher, Jerome Le Carrou, Christine Danel, Mathieu F. Chevalier, Christine Rouzioux, Serge P. Eholie, Jean-Philippe Lavigne, Andre Inwoley, Xavier Anglaret, Laurence Weiss
Summary: In this study, pre-ART plasma levels of sVCAM-1 and sCD14 were found to be independently associated with mortality in sub-Saharan African adults with high CD4 counts.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Letter
Medicine, Research & Experimental
Alexandre Duvignaud, Edouard Lhomme, Thierry Pistone, Racha Onaisi, Remi Sitta, Valerie Journot, Duc Nguyen, Nathan Peiffer-Smadja, Antoine Cremer, Stephane Bouchet, Thomas Darnaud, Delphine Poitrenaud, Lionel Piroth, Christine Binquet, Jean-Francois Michel, Benjamin Lefevre, David Lebeaux, Josselin Lebel, Julie Dupouy, Caroline Roussillon, Anne Gimbert, Linda Wittkop, Rodolphe Thiebaut, Joanna Orne-Gliemann, Jean-Philippe Joseph, Laura Richert, Xavier Anglaret, Denis Malvy
Article
Gastroenterology & Hepatology
Amir M. Mohareb, Gerard Menan Kouame, Audrey Gabassi, Delphine Gabillard, Raoul Moh, Anani Badje, Arlette Emieme, Sarah Maylin, Herve Menan, Emily P. Hyle, Constance Delaugerre, Christine Danel, Xavier Anglaret, Karine Lacombe, Serge P. Eholie, Anders Boyd
Summary: This study investigated the impact of past and active hepatitis B virus (HBV) infection on immunorecovery and mortality in HIV-infected individuals initiating tenofovir-based antiretroviral therapy (ART). The findings suggest that individuals with HIV and past HBV infection, as well as those with isolated anti-HBcAb-positive serology, experience lower mortality compared to individuals with HBsAg and high HBV DNA. Therefore, additional HBV-related management may not be necessary for these individuals.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Medicine, General & Internal
Cecile Cazes, Kevin Phelan, Victoire Hubert, Rodrigue Alitanou, Harouna Boubacar, Lievin Izie Bozama, Gilbert Tshibangu Sakubu, Aurelie Beuscart, Cyrille Yao, Delphine Gabillard, Moumouni Kinda, Augustin Augier, Xavier Anglaret, Susan Shepherd, Renaud Becquet
Article
Infectious Diseases
Nathalie De Castro, Olivier Marcy, Corine Chazallon, Eugene Messou, Serge Eholie, Jean-Baptiste N'takpe, Nilesh Bhatt, Celso Khosa, Isabel Timana Massango, Dither Laureiliard, Giang Do Chau, Ands Domergue, Valdilea Veloso, Rodrigo Escada, Sandra Wagner Cardoso, Constance Delaugerre, Xavier Anglaret, Jean-Michel Molina, Beatriz Grinsztejn
Summary: The study aimed to assess the non-inferiority of raltegravir to efavirenz in HIV and tuberculosis co-infected patients. While raltegravir did not meet the predefined criterion for non-inferiority, it was well tolerated and could be considered as an option for selected patients. The most frequent adverse events were HIV-associated non-AIDS illnesses and AIDS-defining illnesses, with a similar rate of grade 3 or 4 adverse events in both treatment groups.
LANCET INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Marie Jaspard, Mamadou Saliou Sow, Sylvain Juchet, Eric Diendere, Beatrice Serra, Richard Kojan, Billy Sivahera, Caroline Martin, Moumouni Kinda, Hans-Joerg Lang, Fode Bangaly Sako, Fode Amara Traore, Eudoxie Koumbem, Halidou Tinto, Adama Sanou, Apoline Sondo, Flavien Kabore, Joseph Donamou, Jean-Paul-Yassa Guilavogui, Fanny Velardo, Brice Bicaba, Olivier Marcy, Augustin Augier, Sani Sayadi, Armel Poda, Sakoba Keita, Xavier Anglaret, Denis Malvy
Summary: This study analyzed data from two West-African countries' COVID-19 care centers and found that the disease severity in Africa is comparable to other regions. Men, older age individuals, and those with chronic hypertension were at higher risk of death. Vigilance for common risk factors such as older age and hypertension is essential in managing COVID-19 in Africa.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Editorial Material
Medicine, General & Internal
Alexandre Duvignaud, Xavier Anglaret
Article
Infectious Diseases
Delphine Gabillard, Jean-Baptiste N'takpe, Marie-Laure Chaix, Gerard M. Kouame, Raoul Moh, Thomas-d'Aquin Toni, Jerome Le Carrou, Sophie Karcher, Anani Badje, Arlette Emieme, Herve Menan, Christine Danel, Xavier Anglaret, Serge P. Eholie
Summary: The Temprano trial showed that early initiation of ART can reduce the risk of virological failure and drug resistance in the medium term, which is especially important for resource-limited countries. Patients in the deferred group who started ART after 30 months had a higher rate of virological failure and a lower genotypic susceptibility score.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Alexandre Duvignaud, Marie Jaspard, Ijeoma Chukwudumebi Etafo, Delphine Gabillard, Beatrice Serra, Chukwuyem Abejegah, Camille le Gal, Abiodun Tolani Abidoye, Mahamadou Doutchi, Sampson Owhin, Benjamin Seri, Jackson Katembo Vihundira, Marion Bererd-Camara, Justine Schaeffer, Nicolas Danet, Augustin Augier, Ephraim Ogbaini-Emovon, Alex Paddy Salam, Liasu Adeagbo Ahmed, Sophie Duraffour, Peter Horby, Stephan Gunther, Akinola Nelson Adedosu, Oladele Oluwafemi Ayodeji, Xavier Anglaret, Denis Malvy
Summary: The study aimed to document the baseline characteristics and outcomes of Lassa fever patients in Nigeria, highlighting factors associated with mortality. Results suggest that age, disease severity, and certain biological markers were independently associated with mortality, providing valuable information for designing future therapeutic trials.
LANCET GLOBAL HEALTH
(2021)
Review
Immunology
Jennifer M. Ross, Anani Badje, Molebogeng X. Rangaka, A. Sarah Walker, Adrienne E. Shapiro, Katherine K. Thomas, Xavier Anglaret, Serge Eholie, Delphine Gabillard, Andrew Boulle, Gary Maartens, Robert J. Wilkinson, Nathan Ford, Jonathan E. Golub, Brian G. Williams, Ruanne Barnabas
Summary: The study found that isoniazid preventive therapy with antiretroviral therapy significantly reduces the risk of tuberculosis in HIV patients, but the effect on lowering all-cause mortality was not statistically significant. Participants with baseline CD4 counts of less than 500 cells per mu L had increased risk of tuberculosis, but there was no significant difference in the benefit of isoniazid preventive therapy with ART by sex, baseline CD4 count, or results of tuberculin skin test or interferon-gamma release assays.
Review
Pharmacology & Pharmacy
Vincent Madelain, France Mentre, Sylvain Baize, Xavier Anglaret, Cedric Laouenan, Lisa Oestereich, Thi Huyen Tram Nguyen, Denis Malvy, Geraldine Piorkowski, Frederik Graw, Stephan Guenther, Herve Raoul, Xavier de Lamballerie, Jeremie Guedj
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2020)
Letter
Medicine, General & Internal
Thierry Tiendrebeogo, Xavier Anglaret, Renaud Becquet
NEW ENGLAND JOURNAL OF MEDICINE
(2020)