期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 53, 期 2, 页码 247-253出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e3181c6c4b7
关键词
alcohol consumption; alcohol abuse; alcohol dependence; cardiovascular disease; HIV infection; veterans
资金
- NHLBI NIH HHS [R01HL095136, R01 HL095136, R01 HL095136-01] Funding Source: Medline
- NIAAA NIH HHS [K23 AA015914, 2U10AA13566, K24 AA0155674, K24 AA015674, R01 AA013304-05, K23 AA015914-05, U10 AA013566-09, K24 AA015674-04, U10 AA013566, R01 AA013304] Funding Source: Medline
Objective: To determine whether alcohol consumption is associated with cardiovascular disease (CVD) among HIV-infected veterans. Methods: Using established thresholds for alcohol consumption, we analyzed cross-sectional data from 4743 men (51% HIV infected) from the Veterans Aging Cohort Study, a prospective cohort of HIV-infected veterans and demographically similar HIV-uninfected veterans. Using logistic regression, we estimated the odds ratio (OR) for the association between alcohol consumption and prevalent CVD. Results: Among HIV-infected and HIV-uninfected men, respectively, hazardous drinking (33.2% vs. 30.9%,), alcohol abuse and a dependence (20.9% vs. 26.2%), and CVD (14.6% vs. 19.8%) were common. Among HIV-infected men, hazardous drinking [OR = 1.43, 95% confidence interval (CI) = 1.05 to 1.94] and alcohol abuse and dependence (OR = 1.55, 95% CI = 1.07 to 2.23) were associated with a higher prevalence of CVD compared with infrequent and moderate drinking. Among HIV-uninfected men, past drinkers had a higher prevalence of CVD (OR = 1.30, 95% CI = 1.01 to 1.67). For HIV-infected and HIV-uninfected men, traditional risk factors and kidney disease were associated with CVD. Conclusions: Among HIV-infected men, hazardous drinking and alcohol abuse and dependence were associated with a higher prevalence of CVD compared with infrequent and moderate drinking even after adjusting for traditional CVD risk factors, antiretroviral therapy, and CD4 count.
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