Article
Biotechnology & Applied Microbiology
Samrajya Lakshmi Yeruva, Prashant Kumar, Seetharam Deepa, Anand K. Kondapi
Summary: The study developed a novel anti-HIV microbicide, tenofovir- and curcumin-loaded lactoferrin nanoparticles, which effectively inhibited HIV-1 replication and provided sustained drug release at the application site. The nanoparticles showed spermicidal activity and minimal cytotoxicity and inflammation in the vaginal epithelium.
Article
Biotechnology & Applied Microbiology
I. Rodriguez-Izquierdo, M. J. Serramia, R. Gomez, G. Espinosa, M. Genebat, M. Leal, M. A. Munoz-Fernandez
Summary: The study demonstrates the efficacy and biosafety of G2-S16 dendrimer in vaginal human explants, making it a promising candidate for the development of an effective microbicide against HIV-1 infection.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Andrea R. Thurman, Louise A. Ouattara, Nazita Yousefieh, Peter L. Anderson, Lane R. Bushman, Xi Fang, Homaira Hanif, Meredith Clark, Onkar Singh, Gustavo F. Doncel
Summary: This study evaluated a fast-dissolve insert containing tenofovir alafenamide and elvitegravir for preventing HIV and HSV-2 infection. The insert was found to be safe, acceptable, and provided extended mucosal protection. Pharmacokinetic data supported the efficacy of the insert, and in vitro modeling demonstrated protection against both HIV-1 and HSV-2.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ariana Wendy Keel Katz, Ivan C. Balan, Krishnaveni Reddy, Juliane Etima, Kubashni Weber, Thelma Tauya, Millicent Atujuna, Rachel Scheckter, Kenneth Ngure, Lydia Soto-Torres, Nyaradzo Mgodi, Thesla Palanee-Phillips, Jared M. Baeten, Ariane van der Straten
Summary: This study investigated the interpretations and emotional reactions of participants to adherence feedback on the dapivirine vaginal ring. Mixed interpretations were found and emotional reactions focused on external validation of the feedback level itself. The study also highlighted the importance of counseling in helping participants process their reactions and make informed decisions regarding adherence.
Review
Nanoscience & Nanotechnology
Ignacio Rodriguez-Izquierdo, Daniel Sepulveda-Crespo, Jose Maria Lasso, Salvador Resino, Ma Angeles Munoz-Fernandez
Summary: Although many topical microbicides have shown promising results in trials, most of them have failed to prevent sexual transmission of HIV-1 in human clinical trials. Dendrimers, as nanotools, have advanced to human clinical trials and demonstrated their potential as microbicides. This review discusses the advancements in topical microbicide development and the preclinical assays that anionic dendrimers have passed.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emilia Szymanska, Michal Wojasinski, Justyna Dabrowska, Malgorzata Krzyzowska, Magdalena Nowicka, Tomasz Ciach, Katarzyna Winnicka
Summary: In this study, a solution blow spun nanofibrous mat comprising of chitosan and poly(ethylene oxide) was developed as a vaginal platform for preventing sexually transmitted infections. The mat showed uniform drug distribution and physical interactions between the drug and polymers. In vitro studies demonstrated the safety and antiviral efficacy of the drug-loaded mat, as well as the impact of vaginal pH on mucoadhesive and swelling behavior.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Albert Y. Liu, Clara Dominguez Islas, Holly Gundacker, Blazej Neradilek, Craig Hoesley, Ariane van der Straten, Craig W. Hendrix, May Beamer, Cindy E. Jacobson, Tara McClure, Tanya Harrell, Katherine Bunge, Brid Devlin, Jeremy Nuttall, Patrick Spence, John Steytler, Jeanna M. Piper, Mark A. Marzinke
Summary: Vaginal rings containing different dosages of DPV were compared in terms of safety, pharmacokinetics, adherence, and acceptability. Extended duration rings showed higher drug concentrations and were well-tolerated, supporting further evaluation for HIV prevention. Participants demonstrated high adherence and found the rings acceptable for use.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Article
Public, Environmental & Occupational Health
Ariana W. K. Katz, Leila E. Mansoor, Mercy Tsidya, Florence Mathebula, Devika Singh, Samantha Siva, Carolyne Akello, Tinei H. Chitowa, Morgan Garcia, Lydia Soto-Torres, Elizabeth T. Montgomery
Summary: The study found that the majority of women have positive opinions of the dapivirine vaginal ring for HIV prevention, although some have lingering concerns about its partial effectiveness. Most participants were able to easily understand and use emoji stickers to express their opinions on the product, with a few needing interviewer support and encouragement.
Article
Biochemistry & Molecular Biology
Alba Martin-Moreno, Rafael Cena-Diez, Maria Jesus Serramia, Jose Luis Jimenez, Rafael Gomez-Ramirez, Mariangeles Munoz-Fernandez
Summary: The G2-S16 dendrimer has been shown to be an efficient and safe vaginal microbicide for preventing HIV-1 infection, as it does not cause vaginal irritation or tissue damage and has no damaging effects on organs or blood parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
David D. Rahn, Holly E. Richter, Vivian W. Sung, Jessica E. Pruszynski, Linda S. Hynan
Summary: This study aimed to compare the efficacy of perioperative vaginal estrogen with placebo cream on prolapse recurrence following native tissue surgical prolapse repair. The results showed that adjunctive perioperative vaginal estrogen application did not improve surgical success rates after native tissue transvaginal prolapse repair.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Public, Environmental & Occupational Health
Christine Tagliaferri Rael, Doyel Das, Jose Bauermeister, Cody Lentz, Alex Carballo-Dieguez, Rebecca Giguere, Rachel K. Scott, Craig W. Hendrix
Summary: Despite clinicians' advice against vaginal douching, many women still engage in this practice globally. The motivation for douching is primarily for general cleanliness, with water being the most common ingredient in douche solutions. However, there is limited empirical agreement between vaginal douche use and most vaginal health outcomes. Future studies on PrEP vaginal douches should prioritize safety to ensure positive vaginal health outcomes.
Article
Nutrition & Dietetics
Sung-Ho Park, Eun Sil Lee, Sung Taek Park, Soo Young Jeong, Yeoul Yun, YongGyeong Kim, Yulah Jeong, Chang-Ho Kang, Hyun Jin Choi
Summary: Bacterial vaginosis (BV) is a common disease in women caused by abnormal microbiota growth in the vagina. This study evaluated the efficacy and safety of MED-01, a complex of five strains of probiotics, in improving vaginal health. The results showed that MED-01 significantly reduced the Nugent score and increased Lactobacillus plantarum while suppressing harmful bacteria after 12 weeks. No adverse events were observed. Therefore, MED-01 can be used as a probiotic for treating BV.
Article
Public, Environmental & Occupational Health
Brenda Gati Mirembe, Maria Valdez Cabrera, Ariane van der Straten, Rita Nakalega, Mandy Cobbing, Nyaradzo M. Mgodi, Thesla Palanee-Phillips, Ashley J. Mayo, Sufia Dadabhai, Leila E. Mansoor, Samantha Siva, Gonasagrie Nair, Lameck Chinula, Carolyne A. Akello, Clemensia Nakabiito, Lydia E. Soto-Torres, Jared M. Baeten, Elizabeth R. Brown
Summary: This study investigated the use of the dapivirine vaginal ring and found that changing the dispensation schedule from monthly to quarterly did not have a negative impact on acceptance. Having a primary partner who knew about the ring, using long-acting contraception, and having a strong intention to use the ring in the future were associated with higher acceptance rates.
Article
Multidisciplinary Sciences
Alyssa J. Bakke, Toral Zaveri, Molly J. Higgins, Gregory R. Ziegler, John E. Hayes
Summary: Research indicates that physical applicator attributes appealing to women include color, visual appeal, ease of grip, expected ease of use, and expected comfort inside the body. Women typically prefer plastic tampon applicators, which also tend to contain more positive features compared to other types of applicators.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Claudio Gustavino, Paolo Sala, Nadia Cusini, Brunella Gravina, Cecilia Ronzini, Diletta Marcolin, Valerio Gaetano Vellone, Michele Paudice, Rossella Nappi, Sergio Costantini, Simone Ferrero, Fabio Barra
Summary: In the puerperium, the hypoestrogenic state induced by delivery and subsequently sustained by lactation may lead to vaginal dryness, burning, and itching sensation, contributing to the onset of sexual dysfunction. Hydeal-D, a prolonged-release hyaluronic acid derivative, showed significant improvement in sexual function, including desire, arousal, and lubrification among puerperal women, compared to expectant management. Additionally, it led to a decrease in vaginal pH and an increase in the trophic status of vaginal epithelium.
ANNALS OF MEDICINE
(2021)
Article
Obstetrics & Gynecology
Melissa L. Gilliam, Jeffrey T. Jensen, David L. Eisenberg, Michael A. Thomas, Andrea Olariu, Mitchell D. Creinin
Summary: This study aimed to assess the relationship between parity and prior route of delivery to levonorgestrel 52 mg intrauterine system expulsion. Results showed that IUS expulsion occurs in less than 4% of users over the first 6 years of use, mostly during the first year, and is more likely among obese and parous women.
Article
Obstetrics & Gynecology
Namrata Mastey, Melissa C. Matulich, Suji Uhm, Courtney C. Baker, Juliana Melo, Melissa J. Chen, Mitchell D. Creinin
Summary: The study found that high-frequency point-of-care ultrasonography can effectively localize nonpalpable contraceptive implants, leading to successful in-office removal. This method has shown positive results in referral centers.
Letter
Obstetrics & Gynecology
Mitchell D. Creinin
Article
Obstetrics & Gynecology
Mitchell D. Creinin, Carolyn L. Westhoff, Celine Bouchard, Melissa J. Chen, Jeffrey T. Jensen, Andrew M. Kaunitz, Sharon L. Achilles, Jean-Michel Foidart, David F. Archer
Summary: This study assessed the efficacy, cycle control, and safety of an oral contraceptive containing E4 and DRSP, showing it to be an effective contraceptive with a predictable bleeding pattern and low adverse event rates.
Article
Obstetrics & Gynecology
Katherine C. Whitehouse, Bianca M. Stifani, James M. N. Duffy, Caron R. Kim, Mitchell D. Creinin, Teresa DePineres, Beverly Winikoff, Kristina Gemzell-Danielsson, Jennifer Blum, Renee Bracey Sherman, Antonella F. Lavelanet, Dalia Brahmi, Daniel Grossman, Anand Tamang, Hailemichael Gebreselassie, Rodolfo Gomez Ponce de Leon, Bela Ganatra
Summary: By using consensus methods, a core outcome set for future abortion research has been developed, consisting of 15 outcomes that can standardize research, decrease trial heterogeneity, and enhance the quality of systematic reviews and clinical guidelines. Researchers are encouraged to select, collect, and report these core outcomes in future abortion trials, while journal editors should promote the reporting of core outcome sets.
Article
Obstetrics & Gynecology
Suji Uhm, Namrata Mastey, Courtney C. Baker, Melissa J. Chen, Melissa C. Matulich, Melody Y. Hou, Juliana Melo, Susan F. Wilson, Mitchell D. Creinin
Summary: This study aimed to evaluate the impact of mifepristone given 18 to 24 hours before osmotic dilator placement on procedural outcomes. The results showed that mifepristone increased the initial cervical dilation but did not significantly affect the proportion of participants requiring additional dilators. The subjective perception of the procedure and complication rates were similar between the mifepristone and placebo groups.
Article
Pharmacology & Pharmacy
Shelly Kaller, Natalie Morris, M. Antonia Biggs, C. Finley Baba, Sally Ra, Tina R. Raine-Bennett, Mitchell D. Creinin, Erin Berry, Elizabeth A. Micks, Karen R. Meckstroth, Sarah Averbach, Daniel Grossman
Summary: The study aimed to assess the feasibility of pharmacists dispensing mifepristone. Results showed that most pharmacists were willing to be trained, dispensed mifepristone with few challenges, were satisfied with the model, and had higher knowledge levels at follow-up.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Alison Edelman, Agnes Hemon, Mitchell Creinin, Pascale Borensztein, Bruno Scherrer, Anna Glasier
Summary: This study aims to determine the cervical mucus characteristics following a 6-hour delayed pill intake or after one missed pill compared to typical daily use of norgestrel 75 mcg. The study has successfully enrolled 52 subjects and the analysis of the results is pending. The protocol was approved by a central review board and the study procedures were executed successfully.
JMIR RESEARCH PROTOCOLS
(2021)
Editorial Material
Obstetrics & Gynecology
Mitchell Creinin, Julia E. Kohn, Jennifer H. Tang, Tania Basu Serna
Article
Obstetrics & Gynecology
Mitchell D. Creinin, Courtney A. Schreiber, David K. Turok, Carrie Cwiak, Beatrice A. Chen, Andrea Olariu
Summary: This study aimed to evaluate the efficacy and safety of the levonorgestrel 52 mg intrauterine system during years 7 and 8 of use. The results showed that the system is highly effective and safe over an 8-year period of use, with low pregnancy rates and high user satisfaction.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Britany R. Lundberg, Angel Tabuyo-Martin, Matthew D. Ponzini, Machelle D. Wilson, Mitchell D. Creinin
Summary: This study investigated changes in contraceptive method plans before, during, and after abortion among patients. The results showed that most patients received the method they initially identified at the telephone intake, especially those planning to use an IUD or implant. Undecided patients were open to discussing various options.
Editorial Material
Obstetrics & Gynecology
Mitchell D. Creinin, Carolina Sales Vieira, Carolyn L. Westhoff, Diana J. A. Mansour
Summary: This study aims to address limitations in existing definitions of menstrual bleeding changes associated with contraceptive methods and proposes new recommendations for standardized bleeding data analyses. The study suggests three criteria for assessing bleeding outcomes: pattern, flow, and duration, and provides descriptors for each criterion based on the predictability of bleeding patterns. Standardizing outcomes allows for better comparison between studies and improved understanding of differences between contraceptive products for both clinicians and patients.
Letter
Health Care Sciences & Services
Mitchell D. Creinin, Melody Y. Hou
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Cassandra M. Gilbert, Melissa C. Matulich, Matthew D. Ponzini, Machelle D. Wilson, Mitchell D. Creinin
Summary: This study aimed to assess the correlation between quantitative blood loss (QBL) and clinically relevant outcomes or hemorrhage in dilation and evacuation (D&E) procedures. The findings showed that the majority of patients (75%) with clinically relevant bleeding outcomes had a QBL of 500mL or less. Therefore, the need for clinical interventions should be used to define hemorrhage in D&E procedures, rather than a specific amount of blood loss.
Letter
Obstetrics & Gynecology
Mitchell D. Creinin, Jeffrey T. Jensen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)