Article
Endocrinology & Metabolism
Emma Eklund, Anton Hellberg, Bo Berglund, Kerstin Brismar, Angelica Linden Hirschberg
Summary: This study found higher levels of IGF-I, IGFSD, and IGFBP-1 in female athletes compared to controls, with power athletes showing the highest IGFSD. These IGF variables were associated with increased bone mineral density and lean mass, as well as lower fat percentage, and were positively correlated with physical fitness tests.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Rita Schueler, Mariya Markova, Martin A. Osterhoff, Ayman Arafat, Olga Pivovarova, Jurgen Machann, Johannes Hierholzer, Silke Hornemann, Sascha Rohn, Andreas F. H. Pfeiffer
Summary: The study compared the effects of animal and plant protein intake on circulating levels of IGF-1 and IGFBP-1/2 in humans, finding that both diets similarly increased IGF-1 and improved metabolic parameters, while affecting IGFBP-1/2 differently.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Rikke Beck Jensen, Birgitte Bytoft, Zuzana Lohse, Sine Knorr Johnsen, Morten Frost Nielsen, Peter Sandor Oturai, Kurt Hojlund, Peter Damm, Tine D. Clausen, Dorte M. Jensen
Summary: The study found that the relationship between bone mass and IGF-1 in offspring of mothers with type 1 diabetes is influenced by lean mass, while not moderated by insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Physiology
J. Stremming, A. White, A. Donthi, D. G. Batt, B. Hetrick, E. Chang, S. R. Wesolowski, M. B. Seefeldt, C. E. McCurdy, P. J. Rozance, L. D. Brown
Summary: IGF-1 is an important hormone for fetal growth, and an experimental analog called LR3 IGF-1 has been shown to increase fetal organ growth and muscle cell proliferation. However, LR3 IGF-1 has limitations in its regulation and differs from sheep IGF-1. To overcome these limitations, a sheep-specific recombinant IGF-1 called oIGF-1 was developed and found to promote tissue and organ-specific growth in normal sheep fetuses.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Masao Kakoki, Purushotham V. Ramanathan, John R. Hagaman, Ruriko Grant, Jennifer C. Wilder, Joan M. Taylor, J. Charles Jennette, Oliver Smithies, Nobuyo Maeda-Smithies
Summary: Kakoki et al. found that cyanocobalamin (B12) can prevent cardiomyopathy in type 1 diabetic mice by reducing ROS levels and restoring IGF-1 levels through DNMT-SOCS1/3 signaling. B12 shows promising cardioprotective effects and may serve as an option to prevent diabetic cardiomyopathy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Wei Wang, Kang Yu, Shou-Yong Zhao, De-Gang Mo, Jia-Hui Liu, Li-Jinn Han, Tai Li, Heng-Chen Yao
Summary: This study aimed to evaluate the relationship between levels of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 2 (IGFBP-2) at admission and the risk of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS). In patients with acute myocardial infarction, IGF-1 levels were lower and IGFBP-2 levels were higher compared to healthy controls. Follow-up results showed that low levels of IGFBP-2 were associated with a decreased incidence of MACEs. Multivariable Cox regression analysis revealed that IGFBP-2, but not IGF-1, was a positive predictor of MACEs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
Summary: The insulin-like growth factor signalling system plays a crucial role in the growth and development of fishes and shellfishes, serving as important biomarkers for assessing growth and nutritional status in aquaculture.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Oncology
Elena Tirro, Michele Massimino, Chiara Romano, Federica Martorana, Maria Stella Pennisi, Stefania Stella, Giuliana Pavone, Sandra Di Gregorio, Adriana Puma, Cristina Tomarchio, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Summary: The IGF signaling pathway plays a key role in the pathogenesis of GBM, contributing to clinical significance and resistance development to standard and experimental treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Marinna C. Okawa, Rebecca M. Tuska, Marissa Lightbourne, Brent S. Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J. Brown
Summary: Insulin receptor signaling plays a role in growth. Patients with hyperinsulinemia and impaired insulin receptor function show impaired growth and lower bone mineral density, while elevated insulin receptor signaling leads to accelerated growth and higher bone mineral density. This suggests that insulin receptor influences growth through direct metabolic effects in bone and indirect effects via the growth hormone-IGF-1 axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Sara Dam Kobbero, Michael Gajhede, Osman Asghar Mirza, Soren Kloverpris, Troels Ronn Kjaer, Jakob Hauge Mikkelsen, Thomas Boesen, Claus Oxvig
Summary: PAPP-A plays a key role in IGF signaling by cleaving IGFBPs. The structure of PAPP-A in complex with its inhibitor STC2 was reported, revealing a mechanism of proteolytic inhibition that could support the development of specific pharmaceutical agents for modulating IGF signaling.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Wentao Zhong, Xueqing Wang, Yufei Wang, Guoqian Sun, Jia Zhang, Zhuo Li
Summary: Obesity is a global epidemic and a risk factor for endocrine-related cancers. It affects insulin, IGF-1, sex hormones, IGFBPs, and adipokines, with IGF-1 playing a crucial role in obesity-related endocrine cancers. This review discusses the impact of obesity on prostate, breast, and pancreatic cancers, focusing on the mechanism of IGF-1 and its interaction with estrogen and adipokines. Additionally, the current status of IGF-1R inhibitors in clinical practice and their potential combination with other anticancer drugs are briefly introduced.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Claus Oxvig, Cheryl A. Conover
Summary: PAPP-A and PAPP-A2 are specific proteolytic enzymes involved in IGF signaling regulation by cleaving IGFBPs and increasing IGF bioactivity. This molecular network plays a significant role in the IGF system, but its precise operation needs further investigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anne Mette Frobert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Frobert, Cheryl A. Conover, Michael T. Overgaard
Summary: Brown bears shift from circulating ternary IGF/IGFBP/ALS complexes in the active state to binary IGF/IGFBP complexes during hibernation, indicating increased tissue IGF-bioactivity. Furthermore, brown bears use a splice variant of IGF-2, suggesting increased bone-specific targeting of IGF anabolic signaling.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Katherine Tassiopoulos, Yanling Huo, Kunjal Patel, Deborah Kacanek, Susannah Allison, Suzanne Siminski, Sharon L. Nichols, Claude A. Mellins
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Sarah M. Labuda, Yanling Huo, Deborah Kacanek, Kunjal Patel, Krista Huybrechts, Jennifer Jao, Christiana Smith, Sonia Hernandez-Diaz, Gwendolyn Scott, Sandra Burchett, Fatima Kakkar, Ellen G. Chadwick, Russell B. Van Dyke
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Risa M. Hoffman, Meredith G. Warshaw, K. Rivet Amico, Jose Pilotto, Gaerolwe Masheto, Jullapong Achalapong, Elizabeth Machado, Kulkanya Chokephaibulkit, Geraldo Duarte, Esau Joao, Kathleen K. Graham, Katherine M. Knapp, Alice M. Stek, Gwendolyn B. Scott, Anne Coletti, Amy J. Loftis, Nahida Chakhtoura, Judith S. Currier
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2020)
Article
Microbiology
Ahizechukwu C. Eke, Jiajia Wang, Khadija Amin, David E. Shapiro, Alice Stek, Elizabeth Smith, Nahida Chakhtoura, Michael Basar, Kathleen George, Katherine M. Knapp, Esau C. Joao, Kittipong Rungruengthanakit, Edmund Capparelli, Sandra Burchett, Mark Mirochnick, Brookie M. Best
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Pediatrics
Murli U. Purswani, Jonathan S. Russell, Monika Dietrich, Kathleen Malee, Stephen A. Spector, Paige L. Williams, Toni Frederick, Sandra Burchett, Sean Redmond, Howard J. Hoffman, Peter Torre, Sonia Lee, Mabel L. Rice, Tzy-Jyun Yao, Ellen Chadwick, Margaret Ann Sanders, Scott Hunter, William Shearer, Mary Paul, Chivon McMullen-Jackson, Ruth Eser-Jose, Lynnette Harris, Mahoobullah Mirza Baig, Alma Villegas, Lisa Gaye-Robinson, Jawara Dia Cooley, James Blood, Patricia Garvie, William Borkowsky, Sandra Deygoo, Jennifer Lewis, Arry Dieudonne, Linda Bettica, Juliette Johnson, Karen Surowiec, Katherine Knapp, Kim Allison, Megan Wilkins, Jamie Russell-Bell, Nicolas Rosario, Lourdes Angeli-Nieves, Vivian Olivera, Stephan Kohlhoff, Ava Dennie, Jean Kaye, Russell Van Dyke, Karen Craig, Patricia Sirois, Cecelia Hutto, Paige Hickman, Dan Marullo, Veronica Figueroa, Megan Loughran, Sharon Nichols, Elizabeth McFarland, Emily Barr, Christine Kwon, Carrie Glenny, Mobeen Rathore, Kristi Stowers, Saniyyah Mahmoudi, Nizar Maraqa, Rosita Almira, Karen Hayani, Lourdes Richardson, Renee Smith, Alina Miller, Gwendolyn Scott, Maria Mogollon, Gabriel Fernandez, Anai Cuadra, Mariam Davtyan, Jennifer Vinas, Guadalupe Morales-Avendano, Zoe M. Rodriguez, Lizmarie Torres, Nydia Scalley
JOURNAL OF PEDIATRICS
(2020)
Review
Medicine, General & Internal
Sasha Alcon, Billal Ahmed, David Sloane, Youn Seon Lim, Joseph Steven Cervia
JOURNAL OF INVESTIGATIVE MEDICINE
(2020)
Article
Endocrinology & Metabolism
Fabian Schulte, Oliver D. King, Bruce J. Paster, Anna-Barbara Moscicki, Tzy-Jyun Yao, Russell B. Van Dyke, Caroline Shiboski, Mark Ryder, George Seage, Markus Hardt
Article
Immunology
Nehali D. Patel, Ronald H. Dallas, Katherine M. Knapp, Patricia M. Flynn, Aditya H. Gaur
Summary: Starting ART-naive youth with HIV infection on ART at their first clinic visit is feasible, well-accepted, leads to faster viral load suppression, and is associated with high retention in care.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Medicine, General & Internal
Tanzim Bhuiya, Richard Klares, Madellena A. Conte, Joseph Steven Cervia
Summary: Government interventions like mask mandates and social distancing are crucial in controlling the spread of pandemics, with public adherence depending on perceived risk. This study explores the impact of education, income, and country on misperceptions and risk perceptions about COVID-19. Findings show that higher income quartiles are less likely to have misperceptions and personal risk perceptions, with variations across countries. More research is needed to address misperceptions, shape risk perception, and improve science communication for public health initiatives.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Review
Medicine, General & Internal
Peter Thomas Leistikow, Vidhi Patel, Christian Nouryan, Joseph Steven Cervia
Summary: The study found significant differences in HIV test acceptance rates between different care models, with high rates of acceptance in the emergency department (ED) setting in North America and primary care/hospital setting in the rest of the world. Similarly, linkage to care also varied by care model, with high rates of linkage to HIV care in EDs in North America.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Pediatrics
Katherine M. Knapp
PEDIATRIC CLINICS OF NORTH AMERICA
(2022)
Article
Immunology
Brian Kirmse, Charlotte Hobbs, Lisa Aaron, Grace Montepiedra, Marshall Summar, Paige L. Williams, Caitlin J. Smith, Russell Van Dyke, Chunli Yu, Kelli K. Ryckman, William Borkowsky
Summary: FAO appears to be altered in HIV-infected children with and without myopathy, but abnormal FAO does not fully explain myopathy in ARV-exposed children. The study also found an association between myopathy and increased duration of NRTI and protease inhibitor use. Certain single nucleotide polymorphisms (SNPs) in the carnitine transporter gene were associated with the cardiomyopathy phenotype.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Medicine, General & Internal
Kunjal Patel, Yanling Huo, Jennifer Jao, Kathleen M. Powis, Paige L. Williams, Deborah Kacanek, Lynn M. Yee, Ellen G. Chadwick, Stephanie Shiau, Denise L. Jacobson, Sean S. Brummel, Leila Sultan-Beyer, Christian R. Kahlert, Rebecca Zash, George R. Seage
Summary: The study found that dolutegravir was more effective in suppressing viral loads during pregnancy compared to other ART regimens, with no significant safety concerns. Additionally, there were no clear differences in adverse birth outcomes between dolutegravir-based ART and non-dolutegravir-based ART.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Stephanie Shiau, Denise L. Jacobson, Yanling Huo, Deborah Kacanek, Lynn M. Yee, David B. Williams, Lisa B. Haddad, Lena Serghides, Kathleen Powis, Rhoda S. Sperling, Paige L. Williams, Jennifer Jao
Summary: This study investigated the inflammation and immune activation during pregnancy in individuals with HIV and the growth of their HIV-exposed but uninfected children. Results showed that individuals with HIV had higher levels of inflammation and immune activation during pregnancy compared to HIV-negative individuals. Additionally, maternal inflammation and immune activation were associated with the growth of the children at 12 months.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Harsha Adnani, Nirav Agrawal, Akshay Khatri, Jaclyn Vialet, Meng Zhang, Joseph Cervia
Summary: This systematic review evaluates the impact of combination antiretroviral therapy (cART) on disease outcomes in patients with HIV-associated nephropathy (HIVAN) and HIV-immune complex kidney disease (HIVICK). The findings suggest that cART reduces the risk of progression to end-stage kidney disease (ESKD) or death in HIVAN and HIVICK patients.
JOURNAL OF THE INTERNATIONAL ASSOCIATION OF PROVIDERS OF AIDS CARE
(2022)