Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Povilas Budrys, Aaron Peace, Arvydas Baranauskas, Giedrius Davidavicius
Summary: This study compared the effectiveness of FFR and IVUS PCI optimization strategies for long coronary lesions. The results showed that the FFR optimization strategy resulted in poorer functional PCI outcomes and larger myocardial ischemia burden compared to the IVUS optimization strategy. However, this difference did not have a statistically significant impact on clinical outcomes.
Review
Cardiac & Cardiovascular Systems
Rasha K. Al-Lamee, Christopher A. Rajkumar, Sashiananthan Ganesananthan, Allen Jeremias
Summary: Invasive coronary physiology has become established as an important component in guidelines for managing stable coronary artery disease, improving clinical outcomes and cost efficiency. Despite recent doubts from randomized controlled trials, it remains crucial for selecting patients for coronary revascularization.
Article
Cardiac & Cardiovascular Systems
Daniele Pastori, Flavio Giuseppe Biccire, Gregory Yoke Hong Lip, Danilo Menichelli, Pasquale Pignatelli, Francesco Barilla, Francesco Violi, Carlo Gaudio, Gaetano Tanzilli
Summary: Patients with atrial fibrillation have a lower incidence of right coronary artery involvement and generally less severe coronary artery disease compared to non-AF patients. The 2MACE score is associated with left anterior descending artery obstruction and identifies patients with severe CAD.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gaurav Chandola, Jun-Mei Zhang, Ru-San Tan, Ping Chai, Lynette Teo, John C. Allen, Ris Low, Weimin Huang, Shuang Leng, Jiang Ming Fam, Chee Yang Chin, Ghassan S. Kassab, Adrian Fatt Hoe Low, Swee Yaw Tan, Terrance Chua, Soo Teik Lim, Liang Zhong
Summary: The study assessed the feasibility and accuracy of a non-invasive FFR calculation based on CTCA for predicting coronary hemodynamics before and after stenting, finding a good correlation and agreement with invasive FFR, especially in predicting the hemodynamic effects post-stenting, indicating its potential as a useful tool in PCI planning.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The study aimed to evaluate the feasibility and efficacy of a post-PCI FFR-guided optimization strategy compared to standard coronary angiography in achieving final post-PCI FFR values >= 0.90. While the FFR-guided optimization strategy did not significantly increase the proportion of patients with final FFR >= 0.90, it did significantly reduce the proportion of patients with final FFR <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Shinichi Goto, Doyeon Hwang, Jinlong Zhang, Seokhun Yang, Joo Myung Lee, Masahiro Hoshino, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Shao-Liang Chen, Gabor G. Toth, Zsolt Piroth, Abdul Hakeem, Barry F. Uretsky, Yohei Hokama, Nobuhiro Tanaka, Hong-Seok Lim, Tsuyoshi Ito, Akiko Matsuo, Lorenzo Azzalini, Massoud A. Leesar, Carlos Collet, Bon-Kwon Koo, Bernard De Bruyne, Tsunekazu Kakuta
Summary: This study used machine learning algorithms to predict post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) based on baseline information and clinical relevance. The study found a moderate correlation between predicted and actual post-PCI FFR, and the deviation of post-PCI FFR from the predicted value was associated with incident target vessel failure.
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Taishi Yonetsu, Kodai Sayama, Kazuki Matsuda, Hiroki Ueno, Tatsuhiro Nagamine, Toru Misawa, Masahiro Hada, Masahiro Hoshino, Tomoyo Sugiyama, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study investigated the determinants and prognostic implications of changes in coronary flow capacity (CFC) following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The results showed that changes in CFC were associated with the risk of incident target vessel failure (TVF) and were largely predicted by the pre-PCI CFC status.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hu Ai, Naixin Zheng, Le Li, Guojian Yang, Hui Li, Guodong Tang, Qi Zhou, Huiping Zhang, Xue Yu, Feng Xu, Ying Zhao, Fucheng Sun
Summary: This study found that caFFR measurements are well-correlated and in agreement with invasive wire-based FFR measurements before and after PCI. Post-PCI caFFR measurements, similar to wire-based FFR measurements, can help identify patients at higher risk for adverse events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fay M. A. Nous, Tobias Geisler, Mariusz B. P. Kruk, Hatem Alkadhi, Kakuya Kitagawa, Rozemarijn Vliegenthart, Michaela M. Hell, Jorg Hausleiter, Patricia K. Nguyen, Ricardo P. J. Budde, Konstantin Nikolaou, Cezary Kepka, Robert Manka, Hajime Sakuma, Sachin B. Malik, Adriaan Coenen, Felix Zijlstra, Ernst Klotz, Pim van der Harst, Christoph Artzner, Admir Dedic, Francesca Pugliese, Fabian Bamberg, Koen Nieman
Summary: In this multicenter study, the combination of dynamic stress CT myocardial perfusion imaging (CT-MPI) with coronary CT angiography (CTA) showed incremental diagnostic value for the identification of hemodynamically significant coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Jinlong Zhang, Jun Jiang, Xinyang Hu, Yong Sun, Changling Li, Lingjun Zhu, Feng Gao, Liang Dong, Yabin Liu, Jian Shen, Cheng Ni, Kan Wang, Zexin Chen, Haibo Chen, Shiqiang Li, Seokhun Yang, Jeehoon Kang, Doyeon Hwang, Joo-Yong Hahn, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Weon Kim, Jinyu Huang, Fan Jiang, Hao Zhou, Peng Chen, Lijiang Tang, Wenbing Jiang, Xiaomin Chen, Wenming He, Sung Gyun Ahn, Myeong-Ho Yoon, Ung Kim, Joo Myung Lee, You-Jeong Ki, Eun-Seok Shin, Chee Hae Kim, Seung-Jea Tahk, Bon-Kwon Koo, Jian'an Wang
Summary: In cases of intermediate stenosis, women had more favorable outcomes compared to men despite receiving fewer interventions. The use of FFR led to a lower PCI rate but had a similar prognostic value compared to IVUS in both women and men.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Daixin Ding, Jiayue Huang, Jelmer Westra, David Joel Cohen, Yundai Chen, Birgitte Krogsgaard Andersen, Niels Ramsing Holm, Bo Xu, Shengxian Tu, William Wijns
Summary: This article discusses the efficacy of PCI guided by coronary physiology and the importance of immediate post-PCI functional assessment. Studies have shown that better post-PCI functional assessment results are associated with improved clinical outcomes.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Tara Neleman, Alessandra Scoccia, Kaneshka Masdjedi, Mariusz Tomaniak, Jurgen M. R. Ligthart, Karen T. Witberg, Alise Vermaire, Quinten Wolff, Leon Visser, Paul Cummins, Isabella Kardys, Jeroen Wilschut, Roberto Diletti, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen
Summary: Lower post-PCI vFFR values are significantly associated with an increased risk of TVF and TVR at 5 years follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Gassenmaier, Ilias Tsiflikas, Simon Greulich, Jens Kuebler, Florian Hagen, Konstantin Nikolaou, Andreas M. Niess, Christof Burgstahler, Patrick Krumm
Summary: This study evaluated computed tomography fractional flow reserve (FFRCT) values in distal coronary segments of marathon runners, finding a significant occurrence of false-positive values. This phenomenon was commonly observed in participants without anatomical coronary artery stenosis, partially attributable to small distal vessel diameters.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Costa, Claudio Montalto, Mattia Branca, Sung-Jin Hong, Hirotoshi Watanabe, Anna Franzone, Pascal Vranckx, Joo-Yong Hahn, Hyeon-Cheol Gwon, Fausto Feres, Yangsoo Jang, Giuseppe De Luca, Elvin Kedhi, Davide Cao, Philippe Gabriel Steg, Deepak L. Bhatt, Gregg W. Stone, Antonio Micari, Stephan Windecker, Takeshi Kimura, Myeong-Ki Hong, Roxana Mehran, Marco Valgimigli
Summary: The study evaluated the impact of an abbreviated dual antiplatelet therapy (DAPT) regimen in high bleeding risk patients after percutaneous coronary intervention (PCI), using existing evidence. It found that a shorter DAPT duration (1-3 months) reduced bleeding and cardiovascular mortality without increasing ischemic events in these patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Joo Myung Lee, Hyun Kuk Kim, Keun Ho Park, Eun Ho Choo, Chan Joon Kim, Seung Hun Lee, Min Chul Kim, Young Joon Hong, Sung Gyun Ahn, Joon-Hyung Doh, Sang Yeub Lee, Sang Don Park, Hyun-Jong Lee, Min Gyu Kang, Jin-Sin Koh, Yun-Kyeong Cho, Chang-Wook Nam, Bon-Kwon Koo, Bong-Ki Lee, Kyeong Ho Yun, David Hong, Hyun Sung Joh, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, FRAME AMI Invest
Summary: For patients with acute myocardial infarction and multivessel coronary artery disease, FFR-guided PCI is superior to angiography-guided PCI in reducing the risk of death or myocardial infarction.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Jin Chung, Ki Hong Choi, Seung Hun Lee, Doosup Shin, David Hong, Sugeon Park, Hyun Sung Joh, Hyun Kuk Kim, Sang Jin Ha, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: Indeterminate diastolic function is associated with an increased risk of cardiovascular death or admission for heart failure, and is related to coronary microvascular dysfunction. Presence of coronary microvascular dysfunction and elevated left ventricular filling pressure are independent predictors of cardiovascular death or admission for heart failure among patients with indeterminate diastolic function.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
David Hong, Seung Hun Lee, Doosup Shin, Ki Hong Choi, Hyun Kuk Kim, Sang Jin Ha, Hyun Sung Joh, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: This study evaluated the association between cardiac diastolic dysfunction and coronary microvascular dysfunction (CMD) in patients without significant left ventricular systolic dysfunction and epicardial coronary stenosis. The study found that CMD was independently associated with cardiac diastolic dysfunction and both were associated with an increased risk of cardiovascular death or admission for heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Juwon Kim, Ju Youn Kim, Dong Seop Jeong, Tae-Wan Chung, Seung-Jung Park, Kyoung-Min Park, June Soo Kim, Joo Myung Lee, Young Keun On
Summary: This study compared the long-term efficacy, clinical, and safety outcomes of thoracoscopic ablation and radiofrequency catheter ablation as the first procedure for persistent atrial fibrillation. The results showed that both methods had comparable outcomes in terms of rhythm restoration, clinical outcomes, and safety.
Article
Cardiac & Cardiovascular Systems
Felice Gragnano, Roxana Mehran, Mattia Branca, Anna Franzone, Usman Baber, Yangsoo Jang, Takeshi Kimura, Joo-Yong Hahn, Qiang Zhao, Stephan Windecker, Charles M. Gibson, Byeong-Keuk Kim, Hirotoshi Watanabe, Young Bin Song, Yunpeng Zhu, Pascal Vranckx, Shamir Mehta, Sung-Jin Hong, Kenji Ando, Hyeon-Cheol Gwon, Paolo Calabro, Patrick W. Serruys, George D. Dangas, Eugene P. McFadden, Dominick J. Angiolillo, Dik Heg, Marco Valgimigli
Summary: This study suggests that P2Y12 inhibitor monotherapy after complex percutaneous coronary intervention (PCI) can preserve ischemic protection while limiting bleeding risk. Compared with dual antiplatelet therapy (DAPT), P2Y12 inhibitor monotherapy after 1-month to 3-month DAPT can reduce the major bleeding risk in complex PCI patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Joo Myung Lee, Ki Hong Choi, Young Bin Song, Jong-Young Lee, Seung-Jae Lee, Sang Yeub Lee, Sang Min Kim, Kyeong Ho Yun, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yong Hwan Park, Wang Soo Lee, Jin-Ok Jeong, Pil Sang Song, Joon-Hyung Doh, Sang-Ho Jo, Chang-Hwan Yoon, Min Gyu Kang, Jin-Sin Koh, Kwan Yong Lee, Young-Hyo Lim, Yun-Hyeong Cho, Jin-Man Cho, Woo Jin Jang, Kook-Jin Chun, David Hong, Taek Kyu Park, Jeong Hoon Yang, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn
Summary: This study found that intravascular imaging-guided percutaneous coronary intervention (PCI) can reduce the risk of death from cardiac causes, target-vessel-related myocardial infarction, or clinically driven target-vessel revascularization compared to angiography-guided PCI in patients with complex coronary-artery lesions.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ik Hyun Park, Woo Jin Jang, Ju Hyeon Oh, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Chul-Min Ahn, Cheol Woong Yu, Hyun-Joong Kim, Jang-Whan Bae, Sung Uk Kwon, Hyun-Jong Lee, Wang Soo Lee, Jin-Ok Jeong, Sang-Don Park
Summary: This study evaluated the clinical impact of residual non-culprit left main coronary artery disease (LMCAD) on prognosis in patients undergoing emergent percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). The research included 429 patients from 12 centers in the Republic of Korea. The findings suggest that residual non-culprit LMCAD does not appear to increase the risk of major adverse cardiac events (MACEs) at 12 months in patients undergoing emergent PCI for AMI complicated by CS.
Article
Multidisciplinary Sciences
Woo Jin Jang, Ki Hong Choi, Jihoon Kim, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Dong Seop Jeong, Young Bin Song
Summary: This study evaluated the impact of sex on mid-term prognosis in patients who underwent coronary artery bypass grafting (CABG). The results showed that there was no significant difference in the incidence of cardiovascular death or myocardia infarction at 5 years between female and male groups.
Article
Cardiac & Cardiovascular Systems
Ki Hong Choi, Jeong Hoon Yang, Jeong Hun Seo, David Hong, Taeho Youn, Hyun Sung Joh, Seung Hun Lee, Darae Kim, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eun-Seok Jeon
Summary: This study evaluated the discriminative and prognostic roles of invasive measured left ventricular end-diastolic pressure in the population with suspected HFpEF, particularly for patients with intermediate HFA-PEFF score. The results showed that HFA-PEFF score can predict adverse events in HFpEF to some extent, and invasive measured left ventricular end-diastolic pressure can provide additional information for patients with intermediate HFA-PEFF scores.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Ki Hong Choi, Jeong Hoon Yang, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Chul-Min Ahn, Cheol Woong Yu, Ik Hyun Park, Woo Jin Jang, Hyun-Joong Kim, Jang-Whan Bae, Sung Uk Kwon, Hyun-Jong Lee, Wang Soo Lee, Jin-Ok Jeong, Sang-Don Park, Tae-Soo Kang, Hyeon-Cheol Gwon
Summary: This study compared the clinical outcomes of culprit-only percutaneous coronary intervention (PCI) and immediate multivessel PCI in patients with acute myocardial infarction complicated by cardiogenic shock (CS) who underwent venoarterial-extracorporeal membrane oxygenation before revascularization. The results showed that immediate multivessel PCI was associated with lower incidences of 30-day mortality or renal replacement therapy and 12-month follow-up mortality, compared with culprit-only PCI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Jihoon Kim, Danbee Kang, Sung Eun Kim, Hyejeong Park, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eliseo Guallar, Juhee Cho, Joo-Yong Hahn
Summary: In this study, the treatment effects of fimasartan in heart failure patients were compared to other angiotensin II receptor blockers (ARBs). It was found that fimasartan had comparable treatment effects for a composite of all-cause death, recurrent MI, hospitalization for heart failure, and stroke in patients with heart failure after MI.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Sonali Kumar, David Molony, Sameer Khawaja, Kaylyn Crawford, Elizabeth W. Thompson, Olivia Hung, Imran Shah, Jessica Navas-Simbana, Arlen Ho, Arnav Kumar, Yi-An Ko, Hossein Hosseini, Adrien Lefieux, Joo Myung Lee, Joo-Yong Hahn, Shao-Liang Chen, Hiromasa Otake, Takashi Akasaka, Eun-Seok Shin, Bon-Kwon Koo, Goran Stankovic, Dejan Milasinovic, Chang-Wook Nam, Ki-Bum Won, Javier Escaned, Andrejs Erglis, Yoshinobu Murasato, Alessandro Veneziani, Habib Samady
Summary: Coronary stent underexpansion is associated with restenosis and stent thrombosis. High wall shear stress (WSS) has been linked to prothrombotic pathways activation, matrix metalloproteinases upregulation, and future myocardial infarction in atherosclerosis studies. This study aimed to investigate the relationship between stent underexpansion and WSS. The results showed that frames with stent underexpansion were more likely to exhibit high WSS, while no significant association was found between underexpansion and low WSS or between underexpansion and stent platform.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)