Renal Function as Predictor of Mortality in Patients After Percutaneous Transcatheter Aortic Valve Implantation

Objectives The aim of this study was to determine the influence of baseline renal function and periprocedural acute kidney injury (AKI) on prognosis after transcatheter aortic valve implantation (TAVI). Background Evidence is growing that renal function is a major predictor of mortality in patients after TAVI. Methods TAVI was performed with the 18-F Core Valve prosthesis via transfemoral access. All-cause mortality was determined 30 days and 1 year after TAVI in 77 patients with a mean Society of Thoracic Surgeons mortality score of 9.3 +/- 6.1% and a mean logistic European System for Cardiac Operative Risk Evaluation of 31.2 +/- 17.6%. Results Overall procedural success rate was 98% with 1 periprocedural death. The 30-day mortality was 10%, and 1-year mortality was 26%. The mortality risk increased stepwise across quartiles of baseline serum creatinine. An AKI occurred in 20 of 77 patients: 12 patients (60%) with AKI died during follow-up. The incidence of AKI was related to peripheral arterial disease (65% vs. 39%; p = 0.04), the occurrence of a systemic inflammatory response syndrome (60% vs. 21%, p = 0.002), and post-procedural pen-prosthetic regurgitation >= 2+ (35% vs. 9%, p = 0.02). Impaired renal function at baseline reflected by serum creatinine >= 1.58 mg/dl (hazard ratio: 3.9, 95% confidence interval: 1.6 to 9.5; p = 0.002) and the occurrence of AKI (hazard ratio: 5.9, 95% confidence interval: 2.4 to 14.5, p < 0.001) that was not related to the amount of contrast dye were strong predictors of 1-year mortality after TAVI. Conclusions Impaired renal function at baseline and the occurrence of periprocedural AKI, independent whether renal function returns to baseline or not, are strong predictors of 30-day and 1-year mortality after TAVI. (J Am Coll Cardiol Intv 2010;3:1141-9) (C) 2010 by the American College of Cardiology Foundation