Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics

Synchronized switching of multiple toxin–antitoxin modules by (p)ppGpp fluctuation

(2017) Chengzhe Tian et al.   NUCLEIC ACIDS RESEARCH

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing

(2017) Sarah B. Namugenyi et al.   mBio

ATP-Dependent Persister Formation in Escherichia coli

(2017) Yue Shan et al.   mBio

Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells

(2017) Alexander Harms et al.   mBio

Variable Persister Gene Interactions with (p)ppGpp for Persister Formation in Escherichia coli

(2017) Shuang Liu et al.   Frontiers in Microbiology

Mycobacterium smegmatis PhoU Proteins Have Overlapping Functions in Phosphate Signaling and Are Essential

(2017) Alyssa M. Brokaw et al.   Frontiers in Microbiology

Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to IsoniazidIn Vivo

(2016) Yu-Min Chuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulation of Growth, Cell Shape, Cell Division, and Gene Expression by Second Messengers (p)ppGpp and Cyclic Di-GMP in Mycobacterium smegmatis

(2016) Kuldeepkumar Ramnaresh Gupta et al.   JOURNAL OF BACTERIOLOGY

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

(2016) Nityananda Chowdhury et al.   Scientific Reports

What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin–Antitoxin Systems and Persistence?

(2016) Bhaskar C. M. Ramisetty et al.   Frontiers in Microbiology

Persister formation in Staphylococcus aureus is associated with ATP depletion

(2016) Brian P. Conlon et al.   Nature Microbiology

Novel Functions of (p)ppGpp and Cyclic di-GMP in Mycobacterial Physiology Revealed by Phenotype Microarray Analysis of Wild-Type and Isogenic Strains of Mycobacterium smegmatis

(2015) Kuldeepkumar Ramnaresh Gupta et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

Deficiency of the Novel Exopolyphosphatase Rv1026/PPX2 Leads to Metabolic Downshift and Altered Cell Wall Permeability in Mycobacterium tuberculosis

(2015) Yu-Min Chuang et al.   mBio

Selective Target Inactivation Rather than Global Metabolic Dormancy Causes Antibiotic Tolerance in Uropathogens

(2014) Lee W. Goneau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable β-Lactam Antibiotic

(2014) Neeraj Dhar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Staphylococcus aureuschronic and relapsing infections: Evidence of a role for persister cells

(2014) Brian P. Conlon   BIOESSAYS

Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy

(2014) Beatrice Claudi et al.   CELL

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

Dormancy Is Not Necessary or Sufficient for Bacterial Persistence

(2013) Mehmet A. Orman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Polyphosphate Deficiency in Mycobacterium tuberculosis Is Associated with Enhanced Drug Susceptibility and Impaired Growth in Guinea Pigs

(2013) R. Singh et al.   JOURNAL OF BACTERIOLOGY

Essential Roles for Mycobacterium tuberculosis Rel beyond the Production of (p)ppGpp

(2013) L. A. Weiss et al.   JOURNAL OF BACTERIOLOGY

Two Small (p)ppGpp Synthases in Staphylococcus aureus Mediate Tolerance against Cell Envelope Stress Conditions

(2013) T. Geiger et al.   JOURNAL OF BACTERIOLOGY

Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E

(2013) S. Sanyal et al.   MICROBIOLOGY-SGM

A problem of persistence: still more questions than answers?

(2013) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence

(2013) Y.-M. Chuang et al.   mBio

MS_RHII-RSD, a Dual-Function RNase HII-(p)ppGpp Synthetase from Mycobacterium smegmatis

(2012) M. S. Murdeshwar et al.   JOURNAL OF BACTERIOLOGY

The Role of the Novel Exopolyphosphatase MT0516 in Mycobacterium tuberculosis Drug Tolerance and Persistence

(2011) Seema M. Thayil et al.   PLoS One

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria

(2008) O. Gefen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA