期刊
IUBMB LIFE
卷 65, 期 8, 页码 699-709出版社
WILEY
DOI: 10.1002/iub.1189
关键词
anti-inflammatory; bioavailability; caffeic acid phenethyl ester (CAPE); cardioprotective; hepatoprotective; neuroprotective
资金
- Egyptian Joint Supervision Missions Department of the Ministry of Higher Education, Cairo, Egypt
Caffeic acid phenethyl ester (CAPE) is an important active component of honey bee propolis that possesses a plethora of biological activities. Propolis is used safely in traditional medicine as a dietary supplement for its therapeutic benefits. in vitro and in vivo studies in animal models with minimum adverse effects. Its effectiveness was demonstrated in multiple target organs. Despite this fact, it has not been yet investigated as a protective agent or a potential therapy in humans. Investigation of CAPE efficacy in clinical trials is strongly encouraged to elucidate its therapeutic benefit for different human diseases after performing full preclinical toxicological studies and gaining more insights into its pharmacokinetics. (c) 2013 IUBMB Life, 65(8):699-709, 2013
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