期刊
IUBMB LIFE
卷 65, 期 11, 页码 930-935出版社
WILEY
DOI: 10.1002/iub.1217
关键词
PacC activation; pH regulation; pacC gene; pal genes; phosphate sensing; Pi-repressible phosphatases; acid phosphatase; alkaline phosphatase
资金
- FAPESP [2008/58634-7, 2012/03689-7]
- CNPq
- CAPES
- FAEPA
In this article, the experiments used to construct the ambient pH-signaling network involved in the secretion of enzymes by filamentous fungi have been reviewed, focusing on the phosphate-repressible phosphatases in Aspergillus nidulans. Classic and molecular genetics have been used to demonstrate that proteolysis of the transcription factor PacC at alkaline ambient pH is imperative for its action, implying that the full-length version is not an active molecular form of PacC. It has been hypothesized that the transcriptional regulator PacC may be functional at both acidic and alkaline ambient pH, in either the full-length or the proteolyzed form, if it carries a pal-dependent molecular tag. The products of the pal genes are involved in a metabolic pathway that led to the synthesis of effector molecules that tag the pacC product, perhaps facilitating its proteolysis. (c) 2013 IUBMB Life, 65(11):930-935, 2013
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