期刊
IUBMB LIFE
卷 63, 期 9, 页码 775-782出版社
WILEY-BLACKWELL
DOI: 10.1002/iub.507
关键词
curcumin; migration and invasion; hepatoma; caveolin-1
资金
- National Natural Science Foundation of China [31000372, 30970648]
- Research Fund for the Doctoral Program of Higher Education of China [20092105110002]
Mouse hepatoma cellular carinoma cell line (Hca-F) cells have highly invasive and lymphatic metastasis potential in vitro and in vivo. Curcumin (diferuloylmethane) is an active component of the spice turmeric and has a diversity of antitumor activities. However, there is no available information to address the effects of curcumin on migration and invasion of mouse hepatoma Hca-F cells. In this study, we found that curcumin exerted a concentration- and time-dependent inhibitory effect on the migration and invasion of Hen-F cells in vitro. Curcumin inhibited the expression of the tumor promoter caveolin-1 (Cav-1) in in Hca-F cells. Up-regulation of Cav-1 expression by pcDNA3.1/Cav-1 plasmid was able to reverse the curcumin-induced antimigration and anti-invasion effects in vitro. Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells. Taken together, our findings suggest that curcumin can suppress the migratory and invasive ability of mouse hepatoma Hen-F cells, and this action is mediated through a novel mechanism involving inactivation of Cav-1 and EGFR signaling pathways. (C) 2011 1 IUBMB IUBMB Life, 63(9): 775-782, 2011
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