期刊
IUBMB LIFE
卷 62, 期 9, 页码 677-683出版社
WILEY
DOI: 10.1002/iub.368
关键词
VEGF; transgenic mouse model; nephrin promoter; podocyte-specific down-regulation; pathophysiological development
资金
- Northeast Normal University [111056013]
It is well-known that vascular endothelial growth factor (VEGF) plays a key role in development and pathology, but its function in normal adult tissues is rarely understood. Increased use of anti-angiogenic therapies targeting VEGF in human pathologies have shown more and more adverse effects. In this report, a conditional expression model (Tet-On system) was used to down-regulate podocyte VEGF in adult mice, which resulted in many kidney problems, characterized by glomerular morphological changes, proteinuria, reduced water consumption and urination, increased urine electro-conductivity, as well as high susceptibility to BSA stress. Our findings indicated that podocyte-specitic VEGF down-regulation resulted in poor kidney performance and led mice to be more susceptible to further kidney damages. (C) 2010 IUBMB IUBMB Life, 62(9): 677-683, 2010
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