期刊
IUBMB LIFE
卷 61, 期 1, 页码 1-5出版社
WILEY
DOI: 10.1002/iub.127
关键词
serpin; protein aggregation; misfolding; therapeutics; antitrypsin
Protein aggregation is the cause of several human diseases. Understanding the molecular mechanisms involved in protein aggregation requires knowledge of the kinetics and structures populated during the reaction. Arguably, the best structurally characterized misfolding reaction is that of alpha(1)-antitrypsm. alpha(1)-Antitrypsin misfolding leads to both liver disease and emphysema and affect approximately 1 in 2000 of the population. This review will focus on the mechanism of alpha(1)-antitrypsin misfolding and the development of potential therapeutic strategies. (C) 2008 IUBMB
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据