期刊
IUBMB LIFE
卷 62, 期 1, 页码 19-32出版社
WILEY-BLACKWELL
DOI: 10.1002/iub.282
关键词
mitochondrial dynamics; nucleoid; mitochondrial DNA; segregation
资金
- Academy of Finland
- Sigrid Juselius Foundation
- Tampere University Hospital Medical Research Fund
Various proteins involved in replication, repair, and the structural organization of mitochondrial DNA (mtDNA) have been characterized in detail over the past 25 or so years. In addition, in recent years, many proteins were identified with a role in the dynamics of the mitochondrial network. Using advanced imaging and an increasing number of cytological techniques, we have begun to realize that an important aspect to mtDNA maintenance., in both health and disease, is its organization within the dynamic mitochondrial network in discrete protein-DNA complexes usually termed nucleoids. Here, I review recent developments in the study of nucleoid dynamics and proteins. I will discuss the implications of the organization of mtDNA in nucleoids in light of DNA replication, repair, gene expression, segregation, and inheritance. (C) 2009 IUBMB IUBMB Life, 62(1): 19-32, 2010
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