Article
Agriculture, Dairy & Animal Science
Jia-Qi Chen, Qingyu Zhang, Dandan Yu, Rui Bi, Yuhua Ma, Yijiang Li, Long-Bao Lv, Yong-Gang Yao
Summary: This study has identified a suitable milk substitute for artificial rearing of Chinese tree shrew pups, which has shown no obvious adverse effects on their survival, health, and reproductive performance compared to those reared by their mothers. This finding is of great importance in increasing the availability of Chinese tree shrews in laboratory research.
Article
Biochemistry & Molecular Biology
Xiuying Kui, Dandan Qiu, Wenguang Wang, Na Li, Pinfen Tong, Xiaomei Sun, Liangzi Jin, Wei Deng, Jiejie Dai, Caixia Lu
Summary: The tree shrew NPC1L1 has a higher homology with human NPC1L1 compared to rodents. Its expression is highest in the small intestine, with detectable levels in the lung and pancreas. These findings are valuable for understanding the function of tsNPC1L1 in cholesterol absorption and HCV infection.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biology
Bernadette B. Bagon, Junhyeong Lee, Merc Emil Matienzo, Se-Jin Lee, So-Won Pak, Keon Kim, Jeongmin Lee, Chang-Min Lee, In -Sik Shin, Changjong Moon, Min -Jung Park, Dong -il Kim
Summary: Desertification and desert sandstorms caused by global warming increase the risks to human health, especially in relation to Asian sand dust (ASD) exposure which has been found to be associated with higher mortality and hospitalizations due to respiratory diseases. This study shows that ASD administration in mice leads to accumulation of lipid droplets in brown adipose tissues (BAT) and reduced expression of thermogenic genes, impairing cold-induced adaptive thermogenesis. Chronic administration of ASD in mice on a high-fat diet also resulted in unexplained weight loss, indicating potential lethality in obese mice. However, lung inflammation induced by ASD was not exacerbated in mice lacking uncoupling protein 1, which is involved in thermogenesis. Overall, ASD exposure impairs cold-induced adaptive thermogenic responses in mice and increases mortality risk in obese mice.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Luis Felipe Galvao Valdivia, Erique Castro, Rosangela Aparecida dos Santos Eichler, Mayara Franzoi Moreno, Erica de Sousa, Giovanna Freitas Rodrigues Jardim, Albert Souza Peixoto, Maria Nathalia Moraes, Ana Maria de Lauro Castrucci, Jan Nedergaard, Natasa Petrovic, William T. Festuccia, Patricia Reckziegel
Summary: This study found that cold acclimation and PPARγ agonism combined have additive effects in increasing UCP1 content and thermogenic capacity in brown and beige adipocytes, but do not increase basal energy expenditure.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Dabin Lee, Dong Wook Kim, Sanghyuk Yoon, A-Reum Nam, Kang-Hoon Lee, Ki-Hoan Nam, Sang-Mi Cho, Yeodae Yoon, Je-Yoel Cho
Summary: The study demonstrated that CXCL5 plays a critical role in regulating energy metabolism by affecting the expression of proteins involved in fatty acid oxidation, mitochondrial localization, thermogenesis genes, and inflammatory genes. Additionally, CXCL5 promotes the expression of UCP1 in adipocytes, indicating its importance in energy metabolism regulation, particularly in response to cold exposure.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Physiology
Jaycob D. Warfel, Carrie M. Elks, David S. Bayless, Bolormaa Vandanmagsar, Allison C. Stone, Samuel E. Velasquez, Paola Olivares-Nazar, Robert C. Noland, Sujoy Ghosh, Jingying Zhang, Randall L. Mynatt
Summary: This study aimed to investigate the thermogenic mechanisms in rats lacking Ucp1 gene. The results showed that Ucp1(-/-) rats had decreased body weight and adiposity, and exhibited a decline in core temperature under low temperature conditions. Increased mitochondrial lipid metabolism markers in white adipose tissue and skeletal muscle indicated adaptive responses to UCP1 deficiency. These findings provide novel insights into thermogenic responses and highlight Ucp1(-/-) rats as a valuable model for studying thermogenesis.
Article
Zoology
Yue Ren, Ting Jia, Hao Zhang, Zhengkun Wang, Wanlong Zhu
Summary: This study focuses on the genetic diversity and skull morphology adaptation of the Chinese tree shrew (Tupaia belangeri chinensis). The results show significant genetic variation among populations of T. belangeri chinensis in different regions of Yunnan province, with the Chuxiong and Lijiang populations displaying lower genetic diversity. Furthermore, the skull morphology of the tree shrews has adapted to changing environments.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Woo Yong Park, Jinbong Park, Sujin Lee, Gahee Song, In-Koo Nam, Kwang Seok Ahn, Seong-Kyu Choe, Jae-Young Um
Summary: This study demonstrates that the increase in PEX13 protein during cold-induced beige adipocyte recruitment plays a role in the browning process of white adipocytes. By targeting the Pex13 gene through RNA silencing, the expression of thermogenic proteins such as UCP1 and PGC1 alpha was suppressed, indicating the importance of PEX13 in the beige remodeling of white adipocytes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Biochemistry & Molecular Biology
Dong-min Hou, Ting Jia, Qi Li, Zheng-kun Wang, Wan-long Zhu
Summary: The study used LC-MS to analyze the metabolism in white adipose tissue (WAT) and brown adipose tissue (BAT) of Tupaia belangeri during cold acclimation. Significant metabolic differences were found between WAT and BAT, with BAT showing more differential metabolic pathways in response to cold stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Dandan Qiu, Xiuying Kui, Wenguang Wang, Na Li, Pinfen Tong, Xiaomei Sun, Caixia Lu, Jiejie Dai
Summary: The SEC14L2 gene in Chinese tree shrew is closely related to humans and non-human primates, and the tsSEC14L2 protein is most abundant in the liver and small intestine. These findings may provide valuable insights into the function of tsSEC14L2 in HCV infection.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Anatomy & Morphology
Yiwei Feng, Wei Xia, Pengcheng Zhao, Xiang Yi, Anzhou Tang
Summary: This study provides an atlas of the nasal cavity anatomy, histology, and imaging of Tupaia belangeri chinensis, offering insights into its unique anatomical and physiological features compared to humans. The findings confirm the presence of specific structures and airflow pathways in the investigated species, highlighting its potential as a model for nasal cavity functional research.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
D. V. Balabova, S. V. Belenkaya, E. A. Volosnikova, T. Hermes, V. Y. Chirkova, E. A. Sharlaeva, D. N. Shcherbakov, A. N. Belov, A. D. Koval, V. V. Elchaninov
Summary: Genetically engineered chymosin from the tree shrew has been obtained and characterized, showing potential for coagulating cow's milk but with low thermal stability.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alena A. Nikanorova, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin, Nyurgun N. Gotovtsev, Georgii P. Romanov, Aisen V. Solovyev, Sargylana S. Kuzmina, Nikolay N. Sazonov, Sardana A. Fedorova
Summary: Analysis of data from the Yakut population suggests that specific genotypes of the UCP1 and BDNF genes are associated with elevated levels of leptin in females, with UCP1's rs3811787 showing more signs of natural selection possibly related to cold climate adaptation. The distribution of the T-allele (rs3811787) of UCP1 increases from south to north across Eurasia, along the Arctic Ocean shore, indicating a potential role of the UCP1 gene in leptin-mediated thermoregulation mechanism and its allelic variants in human adaptation to cold climate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ecology
Caixia Lu, Mingxue Li, Xiaomei Sun, Na Li, Wenguang Wang, Pinfen Tong, Jiejie Dai
Summary: The domestication of tree shrews is an important advance in laboratory animal development. MiRNA-seq analysis on wild and domestic tree shrews revealed differentially expressed miRNAs in the hippocampus during domestication, potentially linked to various biological pathways.
BMC ECOLOGY AND EVOLUTION
(2021)
Article
Zoology
Dong-Min Hou, Ting Jia, Hui -Juan Wang, Zheng-Kun Wang, Wan -Long Zhu
Summary: In this study, transcriptome sequencing and bioinformatics analysis were conducted to explore the adaptive response of Tupaia belangeri to cold exposure. The results revealed that genes related to oxidative phosphorylation, steroid biosynthesis, glycerophospholipid, and fatty acid metabolism pathways were differentially expressed, suggesting their involvement in the thermogenic function of brown adipose tissue.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yanli Li, Lan Jiang, Wanzhen Mo, Lihu Wang, Lin Zhang, Yunpeng Cao
Summary: Members of the AT-hook motif nuclear localized (AHL) family have diverse and poorly understood functions. This study investigates the evolution of AHLs in plants and highlights their roles in seed development and disease resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Lan Jiang, Mengfei Lin, Han Wang, Hui Song, Lin Zhang, Qingyu Huang, Renrui Chen, Cheng Song, Guohui Li, Yunpeng Cao
Summary: This study presents a high-quality haplotype-resolved genome of B. striata and explores its genomic evolution and polysaccharide biosynthesis, providing important insights into the evolution of orchids and the improvement of medicinal value in B. striata.
Editorial Material
Ecology
Lin Zhang, Buddhi Dayananda, Ji-Gang Xia, Bao-Jun Sun
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Biodiversity Conservation
Ning Li, Ning Tang, Zheng Wang, Lin Zhang
Summary: The health of China's coastal wetlands is crucial for global bird biodiversity. However, land reclamation, invasive species, and over-harvesting have altered the landscape, affecting bird diversity. This study focuses on the impact of long-term habitat changes on wintering waterbirds in the Tiaozini wetland. It reveals that natural habitats decreased while human-modified habitats increased, leading to changes in species number and population size of different waterbird guilds.
ECOLOGICAL INDICATORS
(2022)
Article
Biochemistry & Molecular Biology
Yunpeng Cao, Yanli Li, Lihu Wang, Lin Zhang, Lan Jiang
Summary: In this study, 21 UBPs were identified in Vernicia fordii, and significant functional divergence was observed in UBP orthologs. The findings provide important insights into the evolution of UBPs in Euphorbiaceae and are valuable for marker-assisted breeding in V. fordii.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Lan Jiang, Tingting Fan, Lihu Wang, Lin Zhang, Jun Xu
Summary: This study identified and analyzed the flowering-related genes in Euphorbiaceae species, providing insights into the mechanisms of flowering in these plants. The findings have implications for marker-assisted breeding and improving variety quality.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Dongmin Hou, Huibao Chen, Ting Jia, Lin Zhang, Wenrong Gao, Simeng Chen, Wanlong Zhu
Summary: To investigate the influence of gradient cooling acclimation on body mass regulation in T. belangeri, WAT and BAT were collected from the control group and the gradient cooling acclimation group. Measurements of body mass, food intake, thermogenic capacity, differential metabolites, and metabolic pathways were conducted. The results revealed that gradient cooling acclimation increased body mass, food intake, resting metabolic rate (RMR), non-shivering thermogenesis (NST), and the masses of WAT and BAT. Significant differential metabolites and metabolic pathways were observed in both WAT and BAT.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Lin Zhang, Ning Li, Buddhi Dayananda, Lihu Wang, Huimin Chen, Yunpeng Cao
Summary: The study of the TRP gene in the saurian family provides new evidence for genetic adaptation to the environment, including gene structure, duplication, and selective pressure. These findings contribute to the identification, classification, and potential function of TRP genes in thermal sensors.
Article
Zoology
Hui-Bao Chen, Ting Jia, Zheng-Kun Wang, Wan-Long Zhu
Summary: The study found that exogenous melatonin injections caused a decrease in body mass and food intake, but an increase in resting metabolic rate and nonshivering thermogenesis in red-backed voles. The injections also resulted in enhanced protein content, mitochondrial protein content, and activity of key enzymes in the liver and brown adipose tissue. Furthermore, the effects of melatonin on body mass and thermogenesis differed between the two studied regions, with voles from Kunming being more sensitive to melatonin.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Zoology
Y. Qiu Liao, Ting Jia, Wan-Long Zhu
Summary: Morphological characteristics are influenced by habitat characteristics and show differences within and between species. This study found that Eothenomys miletus from different regions in the Hengduan Mountain have differentiation in bone morphological indices. The length of sternum and lumbar vertebrae showed differences between regions, and trunk and limb bones were longer in regions with low latitude and high temperature. Principal component analysis and cluster analysis divided the populations into two categories. The increase in bone length and mass correlated with body mass, but did not follow Bergmann's Law and was influenced by altitude, temperature, latitude, as well as food, terrain, and living habits.
JOURNAL OF VERTEBRATE BIOLOGY
(2023)
Article
Zoology
Dongmin Hou, Ting Jia, Yue Ren, Wanlong Zhu, Pengfei Liu
Summary: Altitude-driven adaptive variation in body size is common in animals, but the study of other phenotypic trait changes in ectotherms is limited. This study investigated the adaptive evolution of phenotypic traits in response to altitude in the high Himalaya frog Nanorana parkeri. The results revealed sex-specific differences in body mass, organ mass, and limb length along elevation gradients. It was observed that heart and liver mass showed significant negative correlations with increasing altitude in both sexes, suggesting a trade-off in life history strategies among populations.
JOURNAL OF VERTEBRATE BIOLOGY
(2023)
Article
Ecology
Yue Ren, Ting Jia, Yanfei Cai, Lin Zhang, Hao Zhang, Zhengkun Wang, Wanlong Zhu
Summary: This study provides the first detailed account of the genetic and physiological adaptation to changing environmental temperatures and the reasons causing intraspecific divergence in Eothenomys miletus from the Hengduan Mountain region. Significant phenotypic and genetic alterations were observed in E. miletus populations from the HM region, and there was asymmetric gene flow among these populations, indicating an isolation-by-island model.
ECOLOGY AND EVOLUTION
(2023)
Article
Zoology
Ting Jia, Dong-Min Hou, Wan-Long Zhu
Summary: In this study, we conducted a three-factor experiment to investigate the influence of temperature, photoperiod, and food quantity on Apodemus chevrieri. The results showed that body mass, RMR, NST, leptin levels, and hypothalamic neuropeptide gene expression were all significantly affected by these ecological factors. Temperature, food quantity, and photoperiod had different effects on physiological indexes and energy balance in A. chevrieri, and leptin was involved in the regulation of body mass.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Zoology
Dong-Min Hou, Ting Jia, Hui -Juan Wang, Zheng-Kun Wang, Wan -Long Zhu
Summary: In this study, transcriptome sequencing and bioinformatics analysis were conducted to explore the adaptive response of Tupaia belangeri to cold exposure. The results revealed that genes related to oxidative phosphorylation, steroid biosynthesis, glycerophospholipid, and fatty acid metabolism pathways were differentially expressed, suggesting their involvement in the thermogenic function of brown adipose tissue.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Zoology
Gong Xue-na, Jia Ting, Zhang Di, Zhu Wanlong
Summary: The study found that both the region and high-fat diet had significant effects on body weight, food intake, and resting metabolic rate in Eothenomys miletus.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
