mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression ofSKP2,CCND1, andCCNE1

Activation of G protein coupled estrogen receptor (GPER) promotes the migration of renal cell carcinoma via the PI3K/AKT/MMP-9 signals

(2018) Bao-zhang Guan et al.   Cell Adhesion & Migration

Inhibition of mammalian target of rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis

(2014) Pinar Sahin et al.   FERTILITY AND STERILITY

Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER–ERK–mTOR pathway

(2013) Yue-Hua Yang et al.   APOPTOSIS

Phloridzin isolated from Acanthopanax senticosus promotes proliferation of α6 integrin (CD 49f) and β1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway

(2013) Jienny Lee et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation

(2013) Alejandro Parrales et al.   CELLULAR SIGNALLING

Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

(2013) J. Renshaw et al.   CLINICAL CANCER RESEARCH

Nutrient Sensing, Metabolism, and Cell Growth Control

(2013) Hai-Xin Yuan et al.   MOLECULAR CELL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Signal transduction pathways in FSH regulation of rat Sertoli cell proliferation

(2012) María F. Riera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role for endogenous estrogen in prepubertal Sertoli cell maturation

(2012) Eddy Kao et al.   ANIMAL REPRODUCTION SCIENCE

17Beta-Estradiol Signaling and Regulation of Proliferation and Apoptosis of Rat Sertoli Cells1

(2012) Carine Royer et al.   BIOLOGY OF REPRODUCTION

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis

(2012) Pradeep S. Tanwar et al.   HUMAN MOLECULAR GENETICS

Increased testicular Sertoli cell population induced by an estrogen receptor antagonist

(2012) Trish Berger et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

mRNA-Selective Translation Induced by FSH in Primary Sertoli Cells

(2012) Astrid Musnier et al.   MOLECULAR ENDOCRINOLOGY

Mammalian Target of Rapamycin as a Rational Therapeutic Target for Breast Cancer Treatment

(2012) Patricia Mucci LoRusso   ONCOLOGY

Stimulation of Sertoli cell proliferation: defining the response interval to an inhibitor of estrogen synthesis in the boar

(2012) Trish Berger et al.   REPRODUCTION

Cross Talk Between Estradiol and mTOR Kinase in the Regulation of Ovarian Granulosa Proliferation

(2012) James Yu et al.   Reproductive Sciences

Mammary cancer promotion by ovarian hormones involves IGFR/AKT/mTOR signaling

(2012) Arunkumar Arumugam et al.   STEROIDS

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

17β-Estradiol Regulates Cultured Immature Boar Sertoli Cell Proliferation via the cAMP-ERK1/2 Pathway and the Estrogen Receptor β

(2010) Xian-zhong WANG et al.   Agricultural Sciences in China

A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle, and cancer

(2010) Richard K. Assoian et al.   CELL CYCLE

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

(2009) Christine Wohlfahrt-Veje et al.   CLINICAL ENDOCRINOLOGY

Mechanisms of estrogen signaling and gene expression via GPR30

(2009) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression

(2009) Sophie Belin et al.   PLoS One

USF1/2 Transcription Factor DNA-Binding Activity Is Induced During Rat Sertoli Cell Differentiation1

(2008) Michelle A. Wood et al.   BIOLOGY OF REPRODUCTION

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Estrogen Facilitates both Phosphatidylinositol 3-Kinase/Akt and ERK1/2 Mitogen-Activated Protein Kinase Membrane Signaling Required for Long-Term Neuropeptide Y Transcriptional Regulation in Clonal, Immortalized Neurons

(2008) D. Titolo et al.   JOURNAL OF NEUROSCIENCE

Effects of estradiol and FSH on maturation of the testis in the hypogonadal (hpg) mouse

(2008) Helen Baines et al.   Reproductive Biology and Endocrinology

Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells

(2008) Shui Guan et al.   TOXICOLOGY IN VITRO

Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars

(2007) Trish Berger et al.   ANIMAL REPRODUCTION SCIENCE

17Beta-Estradiol Induces the Translocation of the Estrogen Receptors ESR1 and ESR2 to the Cell Membrane, MAPK3/1 Phosphorylation and Proliferation of Cultured Immature Rat Sertoli Cells1

(2007) Thaís F.G. Lucas et al.   BIOLOGY OF REPRODUCTION