Article
Pharmacology & Pharmacy
Yang Yang, Cuiting Lin, Qiang Zheng, Leqi Zhang, Yongmei Li, Qinghua Huang, Ting Wu, Zean Zhao, Lu Li, Jian Luo, Yanqing Jiang, Qun Zhang, Xing Wang, Chenglai Xia, Jianxin Pang
Summary: Hyperuricemia (HUA) is associated with cardiovascular diseases through left ventricular remodeling (LVR) and cardiomyocyte energy metabolic disorder. The study shows that UA-induced injury in cardiomyocytes is linked to cytoplasmic lipid deposition, which can be improved by the FA metabolism-promoting drug L-carnitine (LC). UA inhibits FA transport into the mitochondrial inner matrix by suppressing carnitine palmitoyl transferase 1B (CPT1B). LC intervention can alleviate HUA-associated left ventricular anterior wall thickening in mice. Dysfunction of FA transport is a critical mechanism in cardiomyocyte injury and HUA-associated LVR, and promoting cytoplasmic FA transportation through pharmacological treatment by LC is an effective strategy to attenuate HUA-associated LVR.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Tong Liu, Chenan Liu, Xiaomeng Wang, Yaping Wei, Shuqun Li, Yun Song, Ping Chen, Lishun Liu, Binyan Wang, Hanping Shi
Summary: This study found a negative association between serum L-carnitine concentrations and the risk of overall, digestive system, and non-digestive system cancer.
Article
Health Care Sciences & Services
Pawel Muszynski, Emil Julian Dabrowski, Marta Paslawska, Marta Niwinska, Anna Kurasz, Michal Swieczkowski, Justyna Tokarewicz, Lukasz Kuzma, Marcin Kozuch, Slawomir Dobrzycki
Summary: Hypertension is a global threat to public health, and is one of the most common risk factors for cardiovascular disease. Studies suggest that elevated serum uric acid levels above 5 mg/dL may increase the risk of hypertension complications, such as heart failure, atrial fibrillation, and chronic kidney disease, among individuals with very high cardiovascular risk.
Review
Nutrition & Dietetics
Dong-Dong Wang, Tian-Yun Wang, Yang Yang, Su-Mei He, You-Mei Wang
Summary: The study found that l-carnitine can reduce body mass in type 2 diabetes mellitus patients, while no significant effects were observed with acetyl-l-carnitine or propionyl-l-carnitine. To achieve 80% of the maximal effect, a minimum of 2 grams of l-carnitine daily for at least 2 weeks was required.
FRONTIERS IN NUTRITION
(2021)
Article
Psychiatry
Li-Juan Nie, Jun Liang, Feng Shan, Bao-Shi Wang, Yuan-Yuan Mu, Xie-Hai Zhou, Qing-Rong Xia
Summary: The endogenous L-carnitine and its derivative acetyl-L-carnitine play a role in antidepressant effects and may serve as potential biomarkers for diagnosing MDD. The levels of serum LC and ALC are significantly reduced in patients with MDD, with potential diagnostic value. Furthermore, changes in LC and ALC concentrations could differentiate between effective and ineffective treatment of depression, indicating their potential as novel biomarkers.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Peng Sun, Mengqi Chen, Xiaofan Guo, Zhao Li, Ying Zhou, Shasha Yu, Hongmei Yang, Guozhe Sun, Liqiang Zheng, Yingxian Sun
Summary: The study demonstrated a positive correlation between hypertension, hyperuricemia, and ischemic stroke. Participants with both conditions had a significantly higher risk, especially among women.
Article
Medicine, General & Internal
Lijin Shen, Ya Dong, Mingzhen Li, Zhichao Zhou, Jing Zhang, Yanjie Liu, Wei Zhao
Summary: This study evaluated the change in leukocyte levels caused by hyperuricemia and explored the relationship between leukocyte levels and hypertension in elderly patients. The findings revealed that leukocyte levels were higher in elderly patients with hyperuricemia compared to those without hyperuricemia. Hyperuricemia was found to be an independent risk factor for leukocyte levels and hypertension. Furthermore, chronic inflammation caused by hyperuricemia may be an important pathogenesis of incident hypertension in patients with hyperuricemia.
Article
Cardiac & Cardiovascular Systems
Woohyeun Kim, Tae Hwa Go, Dong Oh Kang, Jieun Lee, Jah Yeon Choi, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dae Ryong Kang, Jang-Young Kim, Eung Ju Kim
Summary: The study investigated the association between uric acid and incident hypertension with a focus on age and sex differences. It found that younger women are at the highest risk of developing uric acid-related incident hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Multidisciplinary Sciences
Qiqi Shi, Ran Wang, Huifeng Zhang, Yaping Shan, Ming Ye, Bing Jia
Summary: The study revealed that elevated SUA levels were associated with increased cardiovascular risk factors in American adolescents, especially in females.
Article
Pediatrics
Johnathon Carboni, Abby Basalely, Pamela Singer, Laura Castellanos, Christine B. Sethna
Summary: This study examined the association between dietary fiber intake and markers of cardiometabolic risk in adolescents, with a focus on blood pressure. The results showed that low dietary fiber intake was significantly associated with higher diastolic blood pressure, body mass index, and uric acid levels. These findings call for prospective studies to investigate the use of fiber intake as a dietary intervention and preventive measure for chronic conditions in childhood.
JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Naowanit Nata, Nanthawut Ninwisut, Pitchamon Inkong, Ouppatham Supasyndh, Bancha Satirapoj
Summary: Febuxostat treatment effectively reduces serum uric acid levels in CKD patients and preserves renal function, but does not improve endothelial dysfunction.
SCIENTIFIC REPORTS
(2023)
Review
Health Care Sciences & Services
Hyunwoo Oh, Chan Hyuk Park, Dae Won Jun
Summary: This meta-analysis study evaluated the effectiveness of L-carnitine in the treatment of chronic liver disease and found that L-carnitine supplementation significantly lowered ALT and AST levels and normalized ALT levels in patients with chronic liver disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lauren J. Rajakovich, Beverly Fu, Maud Bollenbach, Emily P. Balskus
Summary: This study elucidated the anaerobic pathway for TMA generation from L-carnitine by human gut bacteria and discovered a novel TMA-lyase enzyme and bbu gene cluster. These findings provide critical insights into the connection between microbial function and human disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Yurong Xiong, Fang Wangsheng, Shizhi Wang, Wei Zhou, Xiao Huang, Huihui Bao, Xiaoshu Cheng
Summary: This study found a positive association between body fat percentage (BFP) and the risk of hyperuricemia in hypertensive patients, with the risk increasing with higher BFP levels, in both men and women. The relationship remained consistent across different subgroups, indicating a dose-dependent manner of association.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Psychology, Clinical
Abd El Kader Ait Tayeb, Romain Colle, Khalil El-Asmar, Kenneth Chappell, Cecile Acquaviva-Bourdain, Denis J. David, Severine Trabado, Philippe Chanson, Bruno Feve, Laurent Becquemont, Celine Verstuyft, Emmanuelle Corruble
Summary: This study found that patients with major depressive episodes have lower levels of peripheral acetyl-l-carnitine (ALC) and higher levels of l-carnitine compared to healthy controls. After antidepressant treatment, these imbalances are restored, and the severity of mitochondrial dysfunction may predict the response to treatment.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Psychiatry
N. Waszkiewicz, E. M. Kratz, S. Chojnowska, A. Zalewska, K. Zwierz, A. Szulc, S. D. Szajda, A. Nestsiarovich, A. Kapitau, A. Kepka, L. Ostrowska, M. Ferens-Sieczkowska
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Article
Psychiatry
Napoleon Waszkiewicz, Ewa Maria Kratz, Sylwia Chojnowska, Anna Zalewska, Krzysztof Zwierz, Agata Szulc, Slawomir Dariusz Szajda, Anastasiya Nestsiarovich, Andrei Kapitau, Alina Kepka, Lucyna Ostrowska, Miroslawa Ferens-Sieczkowska
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Article
Medicine, Research & Experimental
Beata Zalewska-Szajda, Katarzyna Taranta-Janusz, Sylwia Chojnowska, Napoleon Waszkiewicz, Krzysztof Zwierz, Anna Wasilewska
ADVANCES IN MEDICAL SCIENCES
(2018)
Article
Medicine, Research & Experimental
Beata Zalewska-Szajda, Katarzyna Taranta-Janusz, Sylwia Chojnowska, Napoleon Waszkiewicz, Krzysztof Zwierz, Anna Wasilewska
ADVANCES IN MEDICAL SCIENCES
(2019)
Article
Substance Abuse
Alina Kepka, Piotr Zwierz, Sylwia Chojnowska, Agnieszka Ochocinska, Ewa Skorupa, Marek Szczepanski, Slawomir Dariusz Szajda, Napoleon Waszkiewicz
Review
Nutrition & Dietetics
Alina Kepka, Agnieszka Ochocinska, Malgorzata Borzym-Kluczyk, Ewa Skorupa, Beata Stasiewicz-Jarocka, Sylwia Chojnowska, Napoleon Waszkiewicz
Review
Medicine, General & Internal
Sylwia Chojnowska, Iwona Ptaszynska-Sarosiek, Alina Kepka, Malgorzata Knas, Napoleon Waszkiewicz
Summary: Stress, anxiety and depression are often characterized by activation of the stress axis, leading to similar symptoms and closely related occurrences. Current diagnosis methods lack laboratory tests for confirmation, hence studying salivary components may aid in quick diagnosis and treatment monitoring. Promising salivary biomarkers such as cortisol, sIgA, lysozyme, melatonin, sAA, CgA, and FGF-2, show fluctuations in saliva concentrations, indicating strong associations with psychological issues like stress, depression, and anxiety.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Alina Kepka, Agnieszka Ochocinska, Sylwia Chojnowska, Malgorzata Borzym-Kluczyk, Ewa Skorupa, Malgorzata Knas, Napoleon Waszkiewicz
Summary: L-carnitine plays a vital role in the mitochondrial metabolism of fatty acids in the central nervous system and has been found to be altered in patients with autism spectrum disorder (ASD). Monitoring L-carnitine levels and acylcarnitine profiles can be useful in diagnosing and treating ASD. Supplementation of L-carnitine may help alleviate symptoms in ASD patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Domzalska, Wieslaw Wiczkowski, Aleksandra Szczepkowska, Sylwia Chojnowska, Tomasz Misztal, Fruzsina R. Walter, Maria A. Deli, Hiroshi Ishikawa, Horst Schroten, Christian Schwerk, Janina Skipor
Summary: The study found that acute inflammation stimulated beta-Gluc activity in the ChP and blood plasma, but not in ChP epithelial cells and CSF, and did not affect the concentrations of quercetin and its phase II metabolites in plasma and CSF, except for higher levels of Q3GA in plasma in LPS-treated ewes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Alina Kepka, Agnieszka Ochocinska, Malgorzata Borzym-Kluczyk, Sylwia Chojnowska, Ewa Skorupa, Malgorzata Przychodzen, Napoleon Waszkiewicz
Summary: The ageing population is leading to an increase in neurodegenerative diseases, such as Alzheimer's disease, making it a growing social, economic, and medical concern. Diet and physical activity are now recognized as important factors that can be modified to help prevent or delay the development of these diseases. The pyramid of healthy nutrition and lifestyle highlights the importance of physical activity as the foundation, along with proper diet and mental activity. Consuming a diet rich in vegetables, fruits, cereals, legumes, vegetable oils, and fish, and incorporating Mediterranean and Asian diets, may reduce the risk of neurodegenerative diseases associated with dementia. It is essential to provide up-to-date knowledge on the appropriate dietary model and healthy lifestyle elements to promote good health and longevity.
Article
Medicine, General & Internal
Iwona Ptaszynska-Sarosiek, Sylwia Chojnowska, Slawomir Dariusz Szajda, Michal Szeremeta, Zofia Wardaszka, Urszula Cwalina, Anna Niemcunowicz-Janica, Napoleon Waszkiewicz
JOURNAL OF CLINICAL MEDICINE
(2020)