Article
Medicine, Research & Experimental
Marianna Dankova, Iveta Domorakova, Zuzana Fagova, Milan Stebnicky, Eva Mechirova
Summary: The study demonstrated the effectiveness of remote conditioning in reducing degeneration of spinal cord motor neurons and increasing the number of Hsp70 positive neurons. Late remote postconditioning showed the most significant neuroprotective effect at the 72-hour time point.
Article
Cardiac & Cardiovascular Systems
Attila Kiss, Ping Wu, Michaela Schlederer, Patrick M. Pilz, Petra Lujza Szabo, Jingle Li, Lukas Weber, Chrysoula Vraka, Verena Pichler, Markus Mitterhauser, Xiaoli Zhang, Karin Zins, Dietmar Abraham, Sijin Li, Bruno K. Podesser, Marcus Hacker, Xiang Li
Summary: The study suggests that remote ischemic perconditioning has a positive effect on cardiac sympathetic-nerve innervation following ischemia, but does not significantly affect myocardial metabolism.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Clinical Neurology
Longfei Wu, Ming Wei, Bohao Zhang, Bowei Zhang, Jian Chen, Sifei Wang, Leilei Luo, Shuling Liu, Sijie Li, Changhong Ren, David C. Hess, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study investigated the safety and tolerability of direct ischemic postconditioning (IPostC) in both a dog model and patients with acute ischemic stroke treated with thrombectomy, and found it to be safe, feasible, and tolerable.
Article
Orthopedics
Zhongdi Liu, Wei Huang, Yifan Chen, Zhe Du, Fengxue Zhu, Tianbing Wang, Baoguo Jiang
Summary: The study revealed that I-postC can alleviate tissue injury and kidney inflammation induced by limb I/R injury possibly by inhibiting the TLR4 and NF-kappa B pathways.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Bo Zuo, Sha Zhu, Guisong Wang, Zhengpeng Li
Summary: This study investigated the effect of remote ischemic postconditioning on gene expressions in rat myocardium using transcriptome sequencing. The results showed that remote ischemic postconditioning can significantly decrease infarct size, reduce levels of cardiac IL-1 beta and IL-6, and increase the level of cardiac IL-10. Transcriptome analysis identified ADAMTS15 as a potential inflammation-related gene and a possible therapeutic target for myocardial ischemia reperfusion injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Marta Consegal, Norberto Nunez, Ignasi Barba, Begona Benito, Marisol Ruiz-Meana, Javier Inserte, Ignacio Ferreira-Gonzalez, Antonio Rodriguez-Sinovas
Summary: The study showed that both succinate dehydrogenase (SDH) inhibition and remote ischemic perconditioning (RIC) can reduce myocardial infarction size, but they do not have an additive effect when used together. Furthermore, the concentrations of selected citric acid cycle metabolites in plasma were found to be influenced by protective maneuvers and correlated with irreversible injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Tsoumani, Anastasios Georgoulis, Panagiota-Efstathia Nikolaou, Ioannis V. Kostopoulos, Theano Dermintzoglou, Ioanna Papatheodorou, Anastasia Zoga, Panagiotis Efentakis, Maria Konstantinou, Evangelos Gikas, Nikolaos Kostomitsopoulos, Andreas Papapetropoulos, Antigone Lazou, Alexios- Leandros Skaltsounis, Derek J. Hausenloy, Ourania Tsitsilonis, Ioulia Tseti, Fabio Di Lisa, Efstathios K. Iliodromitis, Ioanna Andreadou
Summary: Oleuropein demonstrates cardioprotective effects against ischemia reperfusion injury by reducing infarct size, possibly through activating antioxidant defense genes via the Nrf-2 axis. Additionally, oleuropein enhances the cardioprotective manifestation of ischemic postconditioning, showing a synergistic effect in experimental models of IRI.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yochai Birnbaum, Regina Ye, Yumei Ye
Summary: Aspirin loading may explain the lack of success of ischemic postconditioning in clinical practice.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Min Jee Jo, Ji Eun Kim, So Yon Bae, Eunjung Cho, Shin Young Ahn, Young Joo Kwon, Gang-Jee Ko
Summary: This study investigated the role of NRF2 in restoring kidney function after IRI in the aging kidney. The expression of NRF2 decreased significantly in the kidneys of old mice, and renal recovery after IRI was impaired in these mice. In NRF2 knockout mice, renal injury during the recovery phase after IRI was aggravated. These findings suggest that NRF2 may be a therapeutic target for the aging kidney.
Article
Pharmacology & Pharmacy
L. Gadzieva, Jovana Bradic, Isidora Milosavljevic, Vladimir Zivkovic, Ivan Srejovic, Vladimir Jakovljevic, Stefani Bolevich, Sergey Bolevich, Nevena Jeremic, Israpil Alisultanovich-Omarov, Jovana Jeremic
Summary: The aim of this study was to investigate and compare the effects of preconditioning, perconditioning, and postconditioning with PCr on ex vivo I-R injury in rat hearts. The results showed that PCr protected cardiac contractility and prevented oxidative damage in all treatment modalities. The most beneficial effects were observed when PCr was applied during the period of ischemia.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Immunology
Jiefu Zhu, Yafei Zhang, Lang Shi, Yao Xia, Hongchu Zha, Huimin Li, Zhixia Song
Summary: This study reveals the protective role of RP105 in ischemic and septic acute kidney injury (AKI). Overexpression of RP105 alleviated renal structural injuries and dysfunction caused by ischemic and septic AKI. RP105 suppressed inflammatory responses mediated by the TLR4 signaling pathway. These findings suggest that RP105 could be a potential target for preventing and treating ischemic and septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Dou Huang, Changwei Chen, Yunxia Zuo, Lei Du, Ting Liu, Geoffrey W. Abbott, Zhaoyang Hu
Summary: This study found that RLIPost reduces pulmonary damage induced by ischemia-reperfusion in both non-diabetic and diabetic rats. The protective mechanism in non-diabetic rats is associated with STAT-3, while in diabetic rats it is independent of STAT-3.
Article
Biochemistry & Molecular Biology
Maria Namwanje, Bijay Bisunke, Thomas V. Rousselle, Gene G. Lamanilao, Venkatadri S. Sunder, Elizabeth C. Patterson, Canan Kuscu, Cem Kuscu, Daniel Maluf, Manjari Kiran, Valeria Mas, James D. Eason, Amandeep Bajwa
Summary: Multiple ex-vivo rapamycin treatments of dendritic cells induced persistent reprogramming of mitochondrial metabolism, resulting in higher mitochondrial content, oxygen consumption rates, and ATP production. Adoptive transfer of these reprogrammed DCs significantly protected kidneys from injury, demonstrating therapeutic capacity to induce an anti-inflammatory regulatory phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Julia Schewe, Marie-Christine Makeschin, Andrej Khandoga, Jiang Zhang, Doris Mayr, Simon Rothenfusser, Max Schnurr, Alexander L. Gerbes, Christian J. Steib
Summary: The study found that ischemic postconditioning (IPostC) has protective effects on both healthy and fatty livers, reducing levels of lactate dehydrogenase and TXB2 while increasing bile flow. In in vivo experiments, IPostC also decreased levels of inflammatory cytokines and modulated gene expressions, thereby protecting the liver from ischemia-reperfusion injury.
DIGESTIVE DISEASES AND SCIENCES
(2021)