期刊
IRISH JOURNAL OF MEDICAL SCIENCE
卷 180, 期 1, 页码 7-13出版社
SPRINGER LONDON LTD
DOI: 10.1007/s11845-010-0512-4
关键词
Vitamin D; Insufficiency; Osteoporosis; Falls; Ireland
Vitamin D insufficiency is an extremely common condition particularly in the older Irish population. This is a consequence of Ireland's geographical position and climate. A recent study showed more than 75% of a cohort of older Irish females had vitamin D insufficiency. We outline the definition of vitamin D insufficiency and deficiency, its sources and metabolism as well as the clinical consequences of deficiency. We explore the current guidelines and discuss the pitfalls in the management of vitamin D replacement and in particular address recent Irish data on the feasibility and efficacy of intramuscular treatment. Vitamin D is important for calcium homeostasis and bone metabolism and reduced levels lead to osteomalacia, exacerbate osteoporosis and increase the risk of falls. Evidence is emerging that vitamin D has a role beyond musculoskeletal health and may impact on the cardiovascular and autoimmune systems, as well as the risk of malignancy.
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