Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Caner Civan, Duygu Has Simsek, Emine Goknur Isik, Yasemin Sanli, Serkan Kuyumcu
Summary: A 69-year-old woman with breast cancer had F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT for evaluation. F-18-FDG PET/CT showed hypermetabolic lymph nodes, while Ga-68-FAPI-04 PET/CT showed negative results for these nodes. Biopsy confirmed metastasis of breast cancer. This case highlights the possibility of false-negative Ga-68-FAPI-04 PET/CT findings in evaluating metastatic spread in breast cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Mohammad Naghavi-Behzad, Marianne Vogsen, Rasmus Molgard Vester, Maiken Madsen Bjerregaard Olsen, Hjalte Oltmann, Poul-Erik Braad, Jon Thor Asmussen, Oke Gerke, Werner Vach, Kristian Kidholm, Annette Raskov Kodahl, Wolfgang Weber, Malene Grubbe Hildebrandt
Summary: This study compared the use of CE-CT, FDG-PET/CT, or a combination of both in monitoring metastatic breast cancer patients. The results showed that patients monitored with FDG-PET/CT alone or in combination with CE-CT had longer overall survival and earlier detection of disease progression.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Mohammad Naghavi-Behzad, Hjalte Rasmus Oltmann, Tural Asgharzadeh Alamdari, Jakob Lykke Bulow, Lasse Ljungstrom, Poul-Erik Braad, Jon Thor Asmussen, Marianne Vogsen, Annette Raskov Kodahl, Oke Gerke, Malene Grubbe Hildebrandt
Summary: This study compared the response categories and impacts on treatment decisions for metastatic breast cancer patients monitored with CE-CT or FDG-PET/CT. The results showed that FDG-PET/CT indicated regression of disease more frequently than CE-CT, suggesting it may be a more suitable imaging modality for monitoring treatment response in metastatic breast cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Linda C. Kelahan, Donald Kim, Moataz Soliman, Ryan J. Avery, Hatice Savas, Rishi Agrawal, Michael Magnetta, Benjamin P. Liu, Yuri S. Velichko
Summary: The size of hepatic metastatic lesions has an impact on the inter-reader reproducibility of CT-based 2D radiomics features. The reproducibility varies depending on the presence of large or small lesions, which could contribute to the variability in radiomics features reproducibility in literature.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Dione Lother, Marie Robert, Elliot Elwood, Sam Smith, Nina Tunariu, Stephen R. D. Johnston, Marina Parton, Basrull Bhaludin, Thomas Millard, Kate Downey, Bhupinder Sharma
Summary: Breast cancer is a heterogeneous disease with diverse tumor behavior and prognosis, in which accurate assessment of disease extent and response to therapy plays a crucial role in its management. Various imaging techniques have been developed, including WB DW-MRI, CCA, novel PET breast cancer-epitope-specific radiotracers, and radiogenomics, to aid in the evaluation of metastatic breast cancer. However, no single imaging technique is perfect, and further studies are needed to optimize the use of these imaging modalities.
Article
Oncology
Mirela Gherghe, Mario-Demian Mutuleanu, Adina Elena Stanciu, Ionela Irimescu, Alexandra Lazar, Xenia Bacinschi, Rodica Maricela Anghel
Summary: Breast cancer patients often develop metastatic bone lesions, and using SPECT-CT quantitative analysis can help differentiate between these lesions and degenerative bone disease, improving diagnostic accuracy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yael Eshet, Noam Tau, Sara Apter, Noam Nissan, Keren Levanon, Rinat Bernstein-Molho, Ofer Globus, Amit Itay, Tal Shapira, Cecilie Oedegaard, Malka Gorfine, Michal Eifer, Tima Davidson, Einav Gal-Yam, Liran Domachevsky
Summary: This study aimed to assess the feasibility of using Ga-68-fibroblast activation protein inhibitor (FAPI) PET/CT for detecting metastatic disease in patients with non-F-18-FDG-avid invasive lobular breast cancer (ILC). The results showed that FAPI PET/CT was more accurate than CT in detecting metastatic lesions in ILC.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Cesar D. Zarate-Garcia, David R. Cardoza-Ochoa, Yazmin Sanchez-Vera, Jorge Ivan Gonzalez-Diaz
Summary: Breast cancer in men is rare but can present with symptoms such as low back pain and skeletal metastases. This case highlights the use of SPECT/CT with Tc-99m-EDDA/HYNIC-inhibitor prostate-specific membrane antigen for diagnosis. The biopsy confirmed infiltrating ductal carcinoma with positive hormone receptors and indeterminate HER2 status.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Mirela Gherghe, Mario-Demian Mutuleanu, Adina Elena Stanciu, Ionela Irimescu, Alexandra Maria Lazar, Radu Valeriu Toma, Oana Gabriela Trifanescu, Rodica Maricela Anghel
Summary: By quantitatively interpreting SPECT-CT images, we can better demonstrate changes in radiotracer uptake between baseline and follow-up scans in breast cancer patients with metastatic bone disease, compared to qualitative assessment. This method provides a standardized and robust approach for patient follow-up evaluation, which is particularly important for research purposes.
Article
Medicine, General & Internal
A. Bardia, S. A. Hurvitz, S. M. Tolaney, D. Loirat, K. Punie, M. Oliveira, A. Brufsky, S. D. Sardesai, K. Kalinsky, A. B. Zelnak, R. Weaver, T. Traina, F. Dalenc, P. Aftimos, F. Lynce, S. Diab, J. Cortes, J. O'Shaughnessy, V Dieras, C. Ferrario, P. Schmid, L. A. Carey, L. Gianni, M. J. Piccart, S. Loibl, D. M. Goldenberg, Q. Hong, M. S. Olivo, L. M. Itri, H. S. Rugo
Summary: Patients with metastatic triple-negative breast cancer treated with Sacituzumab govitecan had significantly longer progression-free and overall survival compared to standard chemotherapy, but experienced more frequent myelosuppression and diarrhea as adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Xiang Yu, Qinghua Zhou, Shuihua Wang, Yu-Dong Zhang
Summary: This paper reviews the recent development of deep learning in breast cancer diagnosis and detection, introduces CAD systems based on deep convolutional neural networks, and discusses the importance of datasets as well as the challenges faced by CAD systems.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2022)
Article
Multidisciplinary Sciences
Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab, Christiane Foerster, Massimo Saini, Selina Budinjas, Karin Strittmatter, Ilona Krol, Bettina Seifert, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christoph Rochlitz, Marcus Vetter, Walter Paul Weber, Nicola Aceto
Summary: The generation of circulating tumor cells (CTCs) with metastatic ability is concentrated during the rest phase, and CTCs generated during the active phase lack metastatic ability. Mechanistically, the upregulation of mitotic genes during the rest phase enables CTCs' metastasis proficiency. Circadian rhythm hormones such as melatonin, testosterone and glucocorticoids dictate the generation dynamics of CTCs, and insulin promotes tumor cell proliferation in a time-dependent manner.
Article
Oncology
Filippo Pesapane, Anna Rotili, Silvia Penco, Marta Montesano, Giorgio Maria Agazzi, Valeria Dominelli, Chiara Trentin, Maria Pizzamiglio, Enrico Cassano
Summary: The study evaluated the difference in inter-reader reproducibility of DWI technology for breast cancer detection between expert and non-expert readers. The results showed better agreement among expert readers and poor agreement among non-expert readers, suggesting that the application of DWI in breast MRI requires a higher level of cognitive ability from expert readers.
Review
Chemistry, Multidisciplinary
Ali Akbar Ashkarran, Zijin Lin, Jatin Rana, Harvey Bumpers, Lorenzo Sempere, Morteza Mahmoudi
Summary: Metastatic breast cancer accounts for 90% of mortalities in women with breast cancer. Traditional treatments like chemotherapy and radiation therapy may have significant side effects and limited effectiveness. However, recent advances in nanomedicine offer promising solutions for the detection and treatment of metastatic breast cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Winther Buus, Finn Rasmussen, Hanne Marie Nellemann, Vibeke Logager, Anders Bonde Jensen, Katrine Rye Hauerslev, Peer Christiansen, Erik Morre Pedersen
Summary: The study compared the diagnostic accuracy of contrast-enhanced CT, dual-layer detector spectral CT (DL-CT), and whole-body MRI (WB-MRI) for detecting metastatic breast cancer. Results showed that DL-CT had significantly higher diagnostic performance and sensitivity per lesion compared to CT and WB-MRI, while on a per-patient basis, DL-CT and WB-MRI had superior diagnostic performance to CT.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maike Bode, Luisa Charlotte Huck, Vanessa Raaff, Lea Hitpass, Till Braunschweig, Sven Nebelung, Christiane Katharina Kuhl
Summary: When biopsy is performed on morphologically similar or equally suspicious calcifications within the same breast, different histopathologic results may be obtained, which can affect clinical management. Therefore, when suspicious calcifications are present in multiple distinct sites within the same breast, biopsy of more than one site should be considered.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Iakovos Amygdalos, Gustav Muller-Franzes, Jan Bednarsch, Zoltan Czigany, Tom Florian Ulmer, Philipp Bruners, Christiane Kuhl, Ulf Peter Neumann, Daniel Truhn, Sven Arke Lang
Summary: Machine learning algorithm can help identify high-risk patients with colorectal liver metastases (CRLM) and assess their overall survival (OS). Predictive factors based on clinicopathological characteristics include preoperative serum carcinoembryonic antigen (CEA) level, age, diameter of the largest metastasis, number of metastases, body mass index, and primary tumor grading. The application of this model can guide patient follow-up and treatment strategies.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maike Bode, Luisa Charlotte Huck, Shuo Zhang, Teresa Nolte, Masami Yoneyama, Sven Nebelung, Christiane Katharina Kuhl
Summary: This study aimed to evaluate the effect of a cylindrical regional-suppression technique (CREST) on image quality and lesion conspicuity in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast. The results showed that CREST can effectively reduce cardiac motion-related artifacts and improve image quality in breast DCE-MRI without impairing lesion conspicuity.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vincent Van den Bosch, Frederic De Beukelaer, Peter Isfort, Sebastian Keil, Christiane K. Kuhl, Philipp Bruners, Federico Pedersoli
Summary: The Long loop technique is an effective approach for repositioning dislodged catheters, especially when traditional methods are not feasible due to narrowing or thrombosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofeng Jiang, Hengyu Zhao, Oliver Lester Saldanha, Sven Nebelung, Christiane Kuhl, Iakovos Amygdalos, Sven Arke Lang, Xiaojian Wu, Xiaochun Meng, Daniel Truhn, Jakob Nikolas Kather, Jia Ke
Summary: A deep learning model based on preoperative MRI scans was developed and validated to predict survival in patients with rectal cancer.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Christiane K. Kuhl
Article
Radiology, Nuclear Medicine & Medical Imaging
Timm Dirrichs, Eric Tietz, Andre Rueffer, Jens Hanten, Thai Duy Nguyen, Ebba Dethlefsen, Christiane K. Kuhl
Summary: This study compares the image quality and radiation dose of ultrahigh-pitch photon-counting CT (PCCT) with that of ultrahigh-pitch dual-source CT (DSCT) in children suspected of having congenital heart defects. The results show that PCCT offers higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and better overall image quality than DSCT at a similar radiation dose.
Article
Oncology
Maike Bode, Simone Schrading, Arghavan Masoumi, Stephanie Morscheid, Sabine Schacht, Timm Dirrichs, Nadine Gaisa, Elmar Stickeler, Christiane K. Kuhl
Summary: The distinction between non-significant and significant lymph node metastases is crucial for guiding further surgical management of the axilla in women with breast cancer. This study aimed to determine the effectiveness of an abbreviated protocol for regional lymph node staging in identifying patients with significant nodal disease. The results showed that a single 3 min coronal T1-weighted sequence obtained with MRI helped rule out the presence of significant nodal disease with a high negative predictive value.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christiane Kuhl, Tibor Csoszi, Wojciech Piskorski, Tomasz Miszalski, Jeong-Min Lee, Pamela M. Otto
Summary: This study compared the effectiveness of Gadopiclenol and Gadobutrol for lesion visualization in body MRI. The results showed that Gadopiclenol at a dose of 0.05 mmol/kg was comparable to Gadobutrol at a dose of 0.1 mmol/kg in terms of lesion evaluation, and both had a similar safety profile.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jens Vogel-Claussen, Torsten Gerriet Blum, Stefan Andreas, Torsten T. Bauer, Joerg Barkhausen, Volker Harth, Hans-Ulrich Kauczor, Wulf Pankow, Katrin Welcker, Rudolf Kaaks, Hans Hoffmann
Summary: The process of implementing early detection of lung cancer with LDCT in Germany has gained significant momentum. A regulation on the early detection of lung cancer is expected to come into effect by the end of 2023. In this position paper, the specialist societies involved in lung cancer screening present key points for a uniform, structured and quality-assured early detection program for lung cancer in Germany.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert Siepmann, Philipp Bruners, Sven Arke Lang, Jan Bednarsch, Iakovos Amygdalos, Katharina Joechle, Federico Pedersoli, Sebastian Keil, Peter Isfort, Tom Florian Ulmer, Christiane Kuhl, Ulf Peter Neumann, Franziska Alexandra Meister, Zoltan Czigany
Summary: This study aimed to investigate the predictive role of visceral aortic calcification (VAC) in the assessment of myocardial infarction in the western European region. The results showed that VAC was associated with postoperative renal dysfunction and early allograft dysfunction, but there was no significant difference in long-term graft and patient survival.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eloisa Zanderigo, Luisa Huck, Martina Distelmaier, Ebba Dethlefsen, Mirjam Maywald, Daniel Truhn, Timm Dirrichs, Mariya Doneva, Volkmar Schulz, Christiane K. Kuhl, Teresa Nolte
Summary: This study utilized MRF to differentiate breast cancer from normal fibroglandular tissue, showing that MRF holds promise for distinguishing between BC and FGT as well as for analyzing pre/post-contrast T1 changes.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2022)
Proceedings Paper
Engineering, Biomedical
Firas Khader, Christoph Haarburger, Jorg-Christian Kirr, Marcel Menke, Jakob Nikolas Kather, Johannes Stegmaier, Christiane Kuhl, Sven Nebelung, Daniel Truhn
Summary: Glaucoma is a eye disease that leads to vision loss and is usually asymptomatic until its late stages. In this study, an artificial intelligence approach based on ocular fundus images was used for glaucoma detection. By combining object detection and classification networks, a high sensitivity for glaucoma detection was achieved.
2022 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING CHALLENGES (IEEE ISBI 2022)
(2022)
Article
Cardiac & Cardiovascular Systems
R. Korenblik, B. Olij, L. A. Aldrighetti, M. Abu Hilal, M. Ahle, B. Arslan, L. J. van Baardewijk, I Baclija, C. Bent, C. L. Bertrand, B. Bjornsson, M. T. de Boer, S. W. de Boer, R. P. H. Bokkers, I. H. M. Borel Rinkes, S. Breitenstein, R. C. G. Bruijnen, P. Bruners, J. C. Camacho, A. Cappelli, U. Carling, B. K. Y. Chan, D. H. Chang, J. Choi, J. Codina Font, M. Crawford, D. Croagh, E. Cugat, R. Davis, D. W. De Boo, F. De Cobelli, J. F. De Wispelaere, O. M. van Delden, M. Delle, O. Detry, A. Dili, J. Erdmann, O. Fisher, C. Fondevila, A. Fretland, F. Garcia Borobia, A. Gelabert, L. Gerard, F. Giuliante, P. D. Gobardhan, F. Gomez, T. Grunberger, D. J. Grunhagen, J. Guitart, J. Hagendoorn, J. Heil, D. Heise, E. Herrero, G. F. Hess, M. H. Hoffmann, R. Iezzi, F. Imani, J. Nguyen, E. Jovine, J. C. Kalff, G. Kazemier, T. P. Kingham, J. Kleeff, O. Kollmar, W. K. G. Leclercq, S. Lopez Ben, V Lucidi, A. MacDonald, D. C. Madoff, S. Manekeller, G. Martel, A. Mehrabi, H. Mehrzad, M. R. Meijerink, K. Menon, P. Metrakos, C. Meyer, A. Moelker, S. Modi, N. Montanari, J. Navines, U. P. Neumann, P. Peddu, J. N. Primrose, X. Qu, D. Raptis, F. Ratti, F. Ridouani, C. Rogan, U. Ronellenfitsch, S. Ryan, C. Sallemi, J. Sampere Moragues, P. Sandstrom, L. Sarria, A. Schnitzbauer, M. Serenari, A. Serrablo, M. L. J. Smits, E. Sparrelid, E. Spuntrup, G. A. Stavrou, R. P. Sutcliffe, I Tancredi, J. C. Tasse, V Udupa, D. Valenti, Y. Fundora, T. J. Vogl, X. Wang, S. A. White, W. A. Wohlgemuth, D. Yu, I. A. J. Zijlstra, C. A. Binkert, M. H. A. Bemelmans, C. van der Leij, E. Schadde, R. M. van Dam
Summary: The DRAGON 1 trial aims to assess the training, implementation, safety, and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) in accelerating liver remnant hypertrophy in patients with colorectal cancer liver metastases. This worldwide multicenter trial focuses on evaluating the safety profile and potential benefits of PVE/HVE in terms of resection feasibility, liver function improvement, and overall and disease-free survival.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Vincent Van den Bosch, Hizirwan Shukri Salim, Njin-Zu Chen, Otto Stroosma, Philipp Bruners, Christiane K. Kuhl, Federico Pedersoli, Peter Isfort
Summary: This study demonstrates the feasibility of a novel augmented reality system for CT-guided liver interventions. It shows that augmented reality can significantly reduce puncture time and partially improve puncture accuracy compared to free-hand interventions.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)