Article
Neurosciences
Yen-Peng Liao, Shin-ichi Urayama, Tadashi Isa, Hidenao Fukuyama
Summary: The study proposed an optimal model mapping method to improve the reliability of perfusion parameter estimation in IVIM study, finding Gaussian, Kurtosis, and Gamma models optimal for different brain tissues. Using the optimal model mapping method resulted in more reliable estimations of perfusion fraction and pseudo diffusion coefficient compared to conventional methods, potentially providing additional information for clinical diagnosis.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Mathematics
Jingting Yao, Muhammad Ali Raza Anjum, Anshuman Swain, David A. Reiter
Summary: This study introduces the IVIM and FFD models based on DWI for skeletal muscle perfusion and provides a mathematical framework for direct transformation of parameters between the two models. In vivo DWI measurements in skeletal muscle are analyzed using both models, demonstrating the difficulty of model selection based on goodness of fit to experimental data. This analysis offers a framework for interpreting and harmonizing perfusion parameters using IVIM and FFD models.
Article
Radiology, Nuclear Medicine & Medical Imaging
Diego Hernando, Yuxin Zhang, Ali Pirasteh
Summary: Diffusion MRI plays a significant role in evaluating abdominal and pelvic disease processes, with quantitative diffusion MRI offering improved standardization of tissue characterization, despite facing challenges such as acquisition artifacts, signal modeling limitations, and biological variability.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin Loh, Tobit Fuehres, Christoph Stuprich, Michael Uder, Marc Saake, Frederik Bernd Laun
Summary: This study compared the differences in IVIM parameters in the liver between different slice settings, and found that there were no significant differences in the parameters between studies using few slices and many slices.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobit Fuehres, Andreas Julian Riexinger, Martin Loh, Jan Martin, Andreas Wetscherek, Tristan Anselm Kuder, Michael Uder, Bernhard Hensel, Frederik Bernd Laun
Summary: The purpose of this study was to investigate the TE-dependence of IVIM parameters and to check if the triexponential pseudodiffusion compartments are associated with arterial and venous blood. TE-dependence was observed for f, f(1) and f(2), while D, D*, D1* and D2* showed no significant TE-dependence. It was found that f(1) and f(2) exhibit a similar TE-dependence as f, suggesting that the triexponential pseudodiffusion compartments are most probably not associated with arterial and venous blood.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qing Hu, Peipei Jiang, Yongjing Feng, Yan Xu, Nan Zhou, Weibo Chen, Li Zhu, Yali Hu, Zhengyang Zhou
Summary: IVIM MR imaging shows potential in evaluating endometrial fibrosis, with a combination model of ADC, D, and f values demonstrating good diagnostic accuracy. ADC performed better than ET in diagnosis, and reproducibility of IVIM parameters was good to excellent, indicating their potential as imaging biomarkers for noninvasive assessment of endometrial fibrosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ricardo Loucao, Ana-Maria Oros-Peusquens, Karl-Josef Langen, Hugo Alexandre Ferreira, N. Jon Shah
Summary: This study demonstrates a clinically applicable protocol for measuring multiple parameters in tissue characterisation, including pseudo-perfusion, Gaussian, and non-Gaussian diffusion. Results from comparing the proposed protocol with conventional protocols show strong correlations, but with a bias towards lower values.
FRONTIERS IN ONCOLOGY
(2021)
Article
Developmental Biology
Junshen He, Zhao Chen, Ting Wen, Liqun Xu, Chunlin Chen, Ping Liu
Summary: This study suggests that IVIM analysis can serve as an important supplement to ultrasound biometry for the noninvasive identification of false positive SGA pregnancies and SGA patients.
Article
Medicine, General & Internal
Samer Merchant, Stewart Yeoh, Mark A. Mahan, Edward W. Hsu
Summary: Peripheral nerve injury is a significant public health challenge, and perfusion in the nerve is a potential biomarker for assessing the injury severity and prognostic outlook. This study explored the application potential of the IVIM-DTI method in evaluating perfusion in peripheral nerves and provided preliminary evidence of its feasibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Amanda Antonelli, Silvia Capuani, Giada Ercolani, Miriam Dolciami, Sandra Ciulla, Veronica Celli, Bernd Kuehn, Maria Grazia Piccioni, Antonella Giancotti, Maria Grazia Porpora, Carlo Catalano, Lucia Manganaro
Summary: This study aimed to evaluate the potential of Intravoxel Incoherent Motion (IVIM) Imaging in identifying and discriminating different forms of intrauterine growth restriction (IUGR) and normal fetuses pregnancies through the quantification of placental micro-perfusion and microstructural features. The results showed that IVIM parameters are effective in discriminating between small for gestational age (SGA) and fetal growth restriction (FGR), and in detecting microvascular subtle impairment. Additionally, the perfusion IVIM parameter (fp) was found to predict fetuses' body weight in IUGR pregnancies, while the diffusion IVIM parameter (D) reflected more rapid microstructural rearrangement in the placenta due to aging processes in the IUGR group.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
Vinh T. Pham, M. A. R. K. Ciccaglione, David G. Ramirez, Richard K. P. Benninger
Summary: The researchers previously found that measurements of pancreas perfusion dynamics can predict disease progression in type 1 diabetes (T1D). Now they tested whether these measurements can predict the success of therapeutic prevention of T1D.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Clinical Neurology
K. Yamashita, R. Kamei, H. Sugimori, T. Kuwashiro, S. Tokunaga, K. Kawamata, K. Furuya, S. Harada, J. Maehara, Y. Okada, T. Noguchi
Summary: The study evaluated the usefulness of intravoxel incoherent motion MR imaging in patients with acute ischemic stroke, showing high interobserver agreement and potential clinical utility in determining treatment strategies for patients, particularly in assessing the presence of presumed penumbral regions.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eyesha Hashim, Darren A. Yuen, Anish Kirpalani
Summary: Quantification of renal flow using IVIM-DWI has the potential to serve as a surrogate measure of IRI severity to estimate the degree of and recovery from DGF. Study results show that IVIM-DWI parameters are negatively correlated with the time to recovery related to MRI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giada Ercolani, Silvia Capuani, Amanda Antonelli, Arianna Camilli, Sandra Ciulla, Roberta Petrillo, Serena Satta, Robert Grimm, Antonella Giancotti, Paolo Ricci, Carlo Catalano, Lucia Manganaro
Summary: The study investigated the microstructural tissue changes in fetal lung and kidney during gestation using IVIM MRI in 34 normal pregnancies. Results showed correlations between IVIM parameters and gestational age, with the perfusion fraction f potentially serving as a marker for pulmonary and renal maturation.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Mihaela Rata, Khurum Khan, David J. Collins, Dow-Mu Koh, Nina Tunariu, Maria Antonietta Bali, James D'Arcy, Jessica M. Winfield, Simona Picchia, Nicola Valeri, Ian Chau, David Cunningham, Matteo Fassan, Martin O. Leach, Matthew R. Orton
Summary: This study compared the use of DCE-MRI and IVIM-DWI methods in assessing response to anti-angiogenic treatment in colorectal liver metastases patients. It was found that DCE-MRI parameters significantly decreased post-treatment, while only the non-perfusion parameter D increased significantly in IVIM-DWI, with no change in perfusion-related parameters.
Review
Radiology, Nuclear Medicine & Medical Imaging
Fritz Schick, Claus Christian Pieper, Patrick Kupczyk, Haidara Almansour, Gabriel Keller, Fabian Springer, Petra Murtz, Christoph Endler, Alois M. Sprinkart, Sascha Kaufmann, Judith Herrmann, Ulrike Attenberger
Summary: Whole-body MRI systems with a field strength of 3 T have been used in clinical diagnostics for about 2 decades, offering higher signal yield for some applications but also potential disadvantages for others. Recent technological advancements have improved the standards of 3 T MRI systems, requiring more complexity in design and operation.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Pediatrics
Alexander Isaak, Leon M. Bischoff, Anton Faron, Christoph Endler, Narine Mesropyan, Alois M. Sprinkart, Claus C. Pieper, Daniel Kuetting, Darius Dabir, Ulrike Attenberger, Julian A. Luetkens
Summary: The Lake Louise criteria showed high diagnostic performance in pediatric and adolescent patients with acute myocarditis, serving as a valuable tool for follow-up. Mapping techniques improved the diagnostic performance of the 2018 Lake Louise criteria.
PEDIATRIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narine Mesropyan, Patrick Kupczyk, Alexander Isaak, Christoph Endler, Anton Faron, Leona Dold, Alois M. Sprinkart, Claus C. Pieper, Daniel Kuetting, Ulrike Attenberger, Julian A. Luetkens
Summary: The study aims to generate synthetic ECV for hepatic applications without the need for Hct sampling, offering an alternative method for non-invasive quantification of hepatic ECV and potentially enabling broader use in routine clinical practice.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marius Vach, Julian A. Luetkens, Anton Faron, Alexander Isaak, Babak Salam, Daniel Thomas, Ulrike Attenberger, Alois M. Sprinkart
Summary: This study aimed to investigate whether total volume of epicardial (ECF) and pericardial fat (PCF) can be estimated by axial single-slice measurements and in a four-chamber view. The results showed strong correlations between axial single-slice measurements and total fat volumes, with the best correlation found at the level of the left coronary artery. The correlations between single-slice measurements in the four-chamber view and total fat volumes were lower. This time-efficient analysis allows for studies of larger patient cohorts and the opportunist determination of ECF/PCF from routine examinations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Nowak, Maike Theis, Barbara D. Wichtmann, Anton Faron, Matthias F. Froelich, Fabian Tollens, Helena L. Geissler, Wolfgang Block, Julian A. Luetkens, Ulrike Attenberger, Alois M. Sprinkart
Summary: This study developed an end-to-end automated deep learning pipeline for the large-scale opportunistic assessment of body composition metrics and sarcopenia biomarkers in clinical routine, achieving high agreement between manual and fully automated analyses.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anton Faron, Alexander Isaak, Narine Mesropyan, Matthaeus Reinert, Katjana Schwab, Judith Sirokay, Alois M. Sprinkart, Franz-Georg Bauernfeind, Darius Dabir, Claus C. Pieper, Annkristin Heine, Daniel Kuetting, Ulrike Attenberger, Jennifer Landsberg, Julian A. Luetkens
Summary: This study investigated the extent of cardiac injury and inflammation related to ICI therapy in cancer patients using cardiac MRI. The results showed that during follow-up, participants displayed significant signs of myocardial edema and inflammation, as well as a decrease in cardiac function compared to baseline.
Article
Medicine, General & Internal
Alexander Isaak, Tiyasha H. Ayub, Waltraut M. Merz, Anton Faron, Christoph Endler, Alois M. Sprinkart, Claus C. Pieper, Daniel Kuetting, Darius Dabir, Ulrike Attenberger, Sebastian Zimmer, Ulrich M. Becher, Julian A. Luetkens
Summary: This study evaluated the diagnostic and prognostic value of cardiac magnetic resonance in acute peripartum cardiomyopathy (PPCM). The results showed that patients with acute PPCM displayed biventricular dysfunction, myocardial edema, and impaired strain parameters, and these factors may have predictive value for left ventricular ejection fraction (LVEF) recovery.
Article
Multidisciplinary Sciences
Carsten Meyer, Alba Maria Paar Perez, Johannes Chang, Alois Martin Sprinkart, Nina Bohling, Andreas Minh Luu, Daniel Kutting, Christian Jansen, Julian Luetkens, Leon Marcel Bischoff, Ulrike Attenberger, Christian P. Strassburg, Jonel Trebicka, Karsten Wolter, Michael Praktiknjo
Summary: This study investigated the prognostic value of two-dimensional (2D) TIPS geometry for the development of TIPS dysfunction, and found that the position of the cranial stent end is independently associated with the development of TIPS dysfunction.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Julian A. Luetkens, Sebastian Nowak, Narine Mesropyan, Wolfgang Block, Michael Praktiknjo, Johannes Chang, Christian Bauckhage, Rafet Sifa, Alois Martin Sprinkart, Anton Faron, Ulrike Attenberger
Summary: This proof-of-concept study explores the potential of deep learning (DL) to support imaging-based differentiation of the etiology of liver cirrhosis. The study shows that deep-learning classifiers have the potential to aid in discriminating liver cirrhosis etiology based on standard MRI.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Anton Faron, Jasmin Abu-Omar, Johannes Chang, Nina Bohling, Alois Martin Sprinkart, Ulrike Attenberger, Jurgen K. Rockstroh, Andreas Minh Luu, Christian Jansen, Christian P. Strassburg, Jonel Trebicka, Julian Luetkens, Michael Praktiknjo
Summary: This study found that there is a synergy between low skeletal muscle mass and large spontaneous portosystemic shunt area (TSA) in predicting the exponentially increased risk of hepatic encephalopathy (HE) development and mortality in patients with liver cirrhosis. Simultaneous screening for sarcopenia and TSA from routine diagnostic CT can help identify high-risk patients using an easy-to-apply algorithm.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Narine Mesropyan, Patrick A. Kupczyk, Leona Dold, Michael Praktiknjo, Johannes Chang, Alexander Isaak, Christoph Endler, Dmitrij Kravchenko, Leon M. Bischoff, Alois M. Sprinkart, Claus C. Pieper, Daniel Kuetting, Christian Jansen, Ulrike Attenberger, Julian A. Luetkens
Summary: The study aimed to assess the diagnostic utility of MRI extracellular volume fraction (ECV) for the severity evaluation of liver cirrhosis according to Child-Pugh class. The results showed that ECV correlated with Child-Pugh score and had a high diagnostic performance in differentiating between different Child-Pugh classes, indicating its potential as a valuable non-invasive biomarker for assessing liver cirrhosis severity.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Lisa-Marie Merz, Mark Born, Guido Kukuk, Alois M. M. Sprinkart, Ingrid Becker, Cristina Martin-Higueras, Bernd Hoppe
Summary: This study investigated the use of MRI technology to detect oxalate deposition in bone in patients with PHI. The results showed that MRI can accurately detect oxalate osteopathy in patients with PHI and distinguish it from renal osteodystrophy. This research provides a new method for the diagnosis and monitoring of PHI.
PEDIATRIC NEPHROLOGY
(2023)
Correction
Pediatrics
Lisa-Marie Merz, Mark Born, Guido Kukuk, Alois M. Sprinkart, Ingrid Becker, Cristina Martin-Higueras, Bernd Hoppe
PEDIATRIC NEPHROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Nowak, Andreas Henkel, Maike Theis, Julian Luetkens, Sergej Geiger, Alois M. Sprinkart, Claus C. Pieper, Ulrike Attenberger
Summary: A deep learning pipeline using MR imaging data for assessing shape, volume, and asymmetry of the lower extremities in patients with lipedema or lymphedema is proposed. The pipeline includes localization of anatomical landmarks and quality-assured tissue segmentation. The results show excellent performance in landmark detection and segmentation, allowing for standardized analysis of tissue volume and distribution.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Petra Muertz, Mark Tsesarskiy, Alois M. Sprinkart, Wolfgang Block, Oleksandr Savchenko, Julian A. Luetkens, Ulrike Attenberger, Claus C. Pieper
Summary: This study evaluated the use of simplified intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) for differentiating malignant and benign breast lesions. The results showed that IVIM analysis had higher accuracy than ADC, especially when used as a stand-alone tool with perfusion analysis.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2022)