4.6 Article

A Novel Method for Analyzing DSCE-Images With an Application to Tumor Grading

期刊

INVESTIGATIVE RADIOLOGY
卷 43, 期 12, 页码 843-853

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLI.0b013e3181893605

关键词

DSCE-MRI; glioma grading; image processing; texture analysis; dynamic histogram analysis

向作者/读者索取更多资源

Objectives: (a.) The development of a novel analysis method, named Dynamic pixel intensity Histogram Analysis (DHA) allowing for pixel intensity-histogram-model-parameter fitting of arbitrary-shaped regions defined in dynamic-susceptibility-contrast-enhanced (DSCE) difference MR-image time-series, and (b) its prospective application and evaluation for glioma grading. Materials and Methods: For each difference-image, pixel intensity histograms of arbitrary-shaped ROIs were computed and fitted using the Levenberg-Marquardt algorithm. Time-dependent histogram center-position- and width-parameters are computed during bolus-passage. The method was applied to 25 patients with low and high grade gliomas. Results: During bolus outflow-time, histogram-center-position-parameter and histogram-width-parameter reach highest significance levels and discriminate gliomas of different grades. The histogram center-position-parameter discriminated grade-II from grade-III, grade-II from grade-IV but not grade-III from grade-IV. The observed histogram width-parameters discriminated grade-II from grade-III (P < 0.00022), grade-II from grade-IV (P < 8.3 10(-7)), and grade-III from grade-IV (P < 0.00063). Conclusions: DHA is a easy-to-use method for glioma grading; the histogram width parameter is best indicator for histologic grade.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Clinical Neurology

Ruptured MCA Aneurysm Mimicking MCA Territory Ischemic Stroke: A Case Report and Review of the Literature

Ignazio De Trizio, Michael Reinert, Thomas Robert

Summary: Intracerebral hemorrhage is considered a major neurologic and neurosurgical emergency that requires timely diagnosis and treatment. A rare occurrence can involve an aneurysmal rupture presenting with isolated ICH. This study presents a case of a 48-year-old woman with ICH and MCA occlusion, ultimately uncovering a large MCA aneurysm treated with clipping.

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY (2022)

Article Clinical Neurology

Coverage of complex tissue defects following open cervicothoracic spine surgery with a lower trapezius island myocutaneous flap-an interdisciplinary approach

Armin Osmanagic, Alessa Schutz, Ivo Bayard, Andreas Raabe, Radu Olariu, Ralph T. Schar

Summary: The study presented the concept and effectiveness of the lower trapezius island myocutaneous flap (LTIMF) for managing complex wound healing disorders following open cervicothoracic spine surgery. Through a review of seven cases, it was found that LTIMF is an effective and reliable option for stable coverage of deep tissue defects with satisfactory cosmetic results and minimal complications.

NEUROSURGICAL REVIEW (2022)

Article Clinical Neurology

Brain Spontaneous Intracranial Hypotension Score for Treatment Monitoring After Surgical Closure of the Underlying Spinal Dural Leak

Tomas Dobrocky, Levin Hani, Roman Rohner, Mattia Branca, Pasquale Mordasini, Sara Pilgram-Pastor, Johannes Kaesmacher, Alessandro Cianfoni, Ralph T. Schar, Jan Gralla, Andreas Raabe, Christian Ulrich, Jurgen Beck, Eike Piechowiak

Summary: This study aimed to assess the suitability of the brain MRI-based SIH score (bSIH) for monitoring treatment success in SIH patients with a proven spinal cerebrospinal fluid (CSF) leak after microsurgical closure of the underlying dural breach.

CLINICAL NEURORADIOLOGY (2022)

Article Clinical Neurology

Risk Factors for Postoperative Cerebrospinal Fluid Leakage After Intradural Spine Surgery

Christopher Marvin Jesse, Helena Schermann, Johannes Goldberg, Marco Gallus, Levin Hani, Andreas Raabe, Ralph T. Schar

Summary: This study found few modifiable risk factors for preventing cerebrospinal fluid leakage (CSFL) after intradural spine surgery. Patients with previous surgery at the index level had a higher risk of CSFL. The occurrence of CSFL resulted in more wound healing disorders and surgical site infections, requiring further treatment.

WORLD NEUROSURGERY (2022)

Editorial Material Clinical Neurology

VANCO Trial-Preliminary Results on the Safety Profile of Intrawound Vancomycin Powder in Complex Spine Surgery

Ralph T. Schaer, Stefan Zimmerli

WORLD NEUROSURGERY (2022)

Article Clinical Neurology

Diagnostic Accuracy of High-Resolution 3D T2-SPACE in Detecting Cerebral Venous Sinus Thrombosis

A. Hakim, C. Kurmann, K. Pospieszny, T. R. Meinel, M. A. Shahin, M. R. Heldner, R. Umarova, S. Jung, M. Arnold, M. El-Koussy

Summary: This study evaluated the diagnostic accuracy of high-resolution 3D T2 sampling perfection with application-optimized contrasts (T2-SPACE) in patients with cerebral venous sinus thrombosis. The results showed that T2-SPACE had better overall performance compared to contrast-enhanced 3D T1-MPRAGE.

AMERICAN JOURNAL OF NEURORADIOLOGY (2022)

Article Clinical Neurology

The impact of spontaneous intracranial hypotension on social life and health-related quality of life

Christopher Marvin Jesse, Levin Hani, Christian Fung, Christian Thomas Ulrich, Ralph T. Schar, Tomas Dobrocky, Eike Immo Piechowiak, Johannes Goldberg, Christoph Schankin, Harri Sintonen, Jurgen Beck, Andreas Raabe

Summary: Spontaneous intracranial hypotension has a significant impact on patients' social life and health-related quality of life, causing long periods of incapacity for work and high economic costs.

JOURNAL OF NEUROLOGY (2022)

Article Clinical Neurology

Epidural Blood Patching in Spontaneous Intracranial Hypotension-Do we Really Seal the Leak?

Eike Piechowiak, Benjamin Aeschimann, Levin Haeni, Johannes Kaesmacher, Pasquale Mordasini, Christopher Marvin Jesse, Christoph J. Schankin, Andreas Raabe, Ralph T. Schaer, Jan Gralla, Juergen Beck, Tomas Dobrocky

Summary: Non-targeted epidural blood patch is an effective treatment providing short-term relief for spontaneous intracranial hypotension patients; however, the success rate of sealing underlying spinal cerebrospinal fluid leaks is low.

CLINICAL NEURORADIOLOGY (2023)

Article Oncology

Functional Outcome in Spinal Meningioma Surgery and Use of Intraoperative Neurophysiological Monitoring

Christopher Marvin Jesse, Pablo Alvarez Abut, Jonathan Wermelinger, Andreas Raabe, Ralph T. Schaer, Kathleen Seidel

Summary: Spinal meningiomas are common spinal tumors that can cause neurological impairment. Surgical resection is the main treatment, and intraoperative neurophysiological monitoring can help in challenging cases. Most patients show improvement after surgery, and the recurrence and complication rates are low.

CANCERS (2022)

Article Clinical Neurology

Anterior Lumbar Interbody Fusion in Elderly Patients: Peri- and Postoperative Complications and Clinical Outcome

Christopher M. Jesse, Lea Mayer, Levin Hani, Johannes Goldberg, Andreas Raabe, Othmar Schwarzenbach, Ralph T. Schar

Summary: This study investigated the peri- and postoperative complications, radiographic parameters, and clinical outcome of anterior lumbar interbody fusion (ALIF) in elderly patients. The results demonstrated that with careful patient selection, ALIF is a safe and effective treatment for elderly patients.

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY (2023)

Article Medicine, General & Internal

Identification of MGMT Downregulation Induced by miRNA in Glioblastoma and Possible Effect on Temozolomide Sensitivity

Andrea Cardia, Samantha Epistolio, Ismail Zaed, Nora Sahnane, Roberta Cerutti, Debora Cipriani, Jessica Barizzi, Paolo Spina, Federico Mattia Stefanini, Michele Cerati, Sergio Balbi, Luca Mazzucchelli, Fausto Sessa, Gianfranco Angelo Pesce, Michael Reinert, Milo Frattini, Francesco Marchi

Summary: The study evaluated MGMT expression, methylation, and miRNA expression in 112 GBM patients and correlated them with clinical outcomes. The results showed significant associations between MGMT IHC, miRNA expression, and patient survival. The data reinforce the clinical relevance of miRNA expression as a marker to predict the efficacy of chemoradiation in GBM.

JOURNAL OF CLINICAL MEDICINE (2023)

Article Clinical Neurology

Safety and efficacy of stand-alone anterior lumbar interbody fusion in low-grade L5-S1 isthmic spondylolisthesis

C. Marvin Jesse, Othmar Schwarzenbach, Christian T. Ulrich, Levin Hani, Andreas Raabe, Ralph T. Schar

Summary: This study evaluated the safety and efficacy of stand-alone anterior lumbar interbody fusion (ALIF) in patients with symptomatic low-grade L5-S1 isthmic spondylolisthesis. The retrospective analysis showed that the patients improved clinically after one and two years, without intraoperative complications. A small number of patients required reoperation.

BRAIN AND SPINE (2022)

Article Clinical Neurology

Natural history of meningiomas: a serial volumetric analysis of 240 tumors

Pascal Thomann, Levin Hani, Sonja Vulcu, Alessa Schutz, Maximilian Frosch, Christopher Marvin Jesse, Marwan El-Koussy, Nicole Soll, Arsany Hakim, Andreas Raabe, Philippe Schucht

Summary: The management of asymptomatic intracranial meningiomas is controversial. This study aimed to assess growth predictors and develop clinical pathways for their management. The presence of calcifications and iso-/hyperintensity on T2-weighted imaging can stratify meningiomas as low, intermediate, or high risk, allowing for longer follow-up intervals for low and intermediate-risk tumors.

JOURNAL OF NEUROSURGERY (2022)

Article Clinical Neurology

Clinical and radiological outcome 1-year after cervical total disc replacement using the Signus ROTAIO - Prosthesis

Anna Lang, Sara Lener, Lukas Grassner, Anto Abramovic, Claudius Thome, Dennis Paesler, Jens Lehmberg, Ralph Schaer, Sebastian Hartmann

Summary: This study assesses the radiological and clinical correlation of instantaneous center of rotation (iCOR) and range of motion (ROM) following cervical total disc replacement (cTDR). The results show that implantation of the tested prosthesis maintains the ROM and results in a physiological iCOR. The exact position of the device correlates with the clinical outcome, emphasizing the importance of implant design and precise implant positioning.

EUROPEAN SPINE JOURNAL (2022)

Article Clinical Neurology

A standardized model for in vitro testing of sutures and patches for watertight dural closure

Florian Ebel, Stefan Wanderer, C. Marvin Jesse, Ralph T. Schar, Irena Zubak, Christian T. Ulrich, Andreas Raabe

Summary: A standardized in vitro model was developed to test different grafts and suture techniques for watertight dural closure. The study found that there was no significant difference between running and simple interrupted suture techniques. Adding a patch or sealant resulted in higher hydrostatic burst pressure. The highest pressure was achieved with the combination of specific grafts and sealants.

JOURNAL OF NEUROSURGERY (2022)

暂无数据