Article
Ophthalmology
David A. Berntsen, Anita Ticak, Loraine T. Sinnott, Moriah A. Chandler, Jenny Huang Jones, Ann Morrison, Lisa A. Jones-Jordan, Jeffrey J. Walline, Donald O. Mutti
Summary: The study aimed to evaluate the relationship between peripheral defocus, pupil size, and different types of contact lenses on axial growth in children. The results showed that the lens type had a greater impact on eye growth than peripheral defocus, and pupil size had no significant effect. These findings are important for guiding the use of contact lenses in children.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Medicine, General & Internal
Hanyu Zhang, Carly S. Y. Lam, Wing-Chun Tang, Myra Leung, Hua Qi, Paul H. Lee, Chi-Ho To
Summary: The aim of this study is to investigate the influence of baseline relative peripheral refraction (RPR) on myopia control effects in Chinese myopic children wearing Defocus Incorporated Multiple Segments (DIMS) lenses. The results showed that baseline myopic RPR was associated with more myopic progression and greater axial elongation in the DIMS group, but not in the single vision (SV) group. Children with baseline myopic RPR in the DIMS group had statistically significant more myopia progression and axial elongation compared to those with baseline hyperopic RPR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Donald O. Mutti, Loraine T. Sinnott, David A. Berntsen, Lisa A. Jones-Jordan, Danielle J. Orr, Jeffrey J. Walline
Summary: This study compared axial and peripheral eye elongation during myopia therapy with multifocal soft contact lenses. The findings suggest that wearing +2.50 D addition multifocal contact lenses can neutralize or reverse the increase in retinal steepness caused by single vision lenses.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Han Yu Zhang, Carly Siu Yin Lam, Wing Chun Tang, Paul H. Lee, Dennis Y. Tse, Chi Ho To
Summary: This study aimed to investigate the impact of switching from single vision (SV) lenses to Defocus Incorporated Multiple Segments (DIMS) lenses on relative peripheral refraction (RPR) in children with myopia, as well as the changes in RPR in children who wore DIMS lenses for 3 years. The results showed symmetrical changes in RPR in children switching to DIMS lenses and a stable RPR profile in children wearing DIMS lenses for 3 years. Myopia control and RPR changes were influenced by the use of myopic defocus in the mid-periphery, leading to a retardation in myopia progression.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Biochemical Research Methods
Xiaoyun Xi, Jiangdong Hao, Zhenghua Lin, Sidi Wang, Zhikuan Yang, Weizhong Lan, Pablo Artal
Summary: This study aims to establish a database of two-dimensional (2D) peripheral refraction profiles in adults and explore the features for different central refraction values. The results showed that there were differences in peripheral refraction among different groups with myopia/ slight myopia/ hyperopia, and the defocus deviations varied in different regions with central refraction. The defocus asymmetry between the upper and lower retinas within 16 degrees increased with the increase of central myopia. These results provide rich information for possible individual corrections and lens design by characterizing the variation of peripheral defocus with central myopia.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Ian G. Beasley, Leon N. Davies, Nicola S. Logan
Summary: This study aimed to investigate the effects of using multifocal soft contact lenses on axial growth and refractive error in hyperopic children. The results showed that using centre-near multifocal soft contact lenses can accelerate axial growth in hyperopic children.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Ophthalmology
Antonio Queiros, Alejandro Cervino, Jose Manuel Gonzalez-Meijome
Summary: This study measured the refraction patterns of myopic eyes with spectacle lenses correction and lens-free emmetropes at different target distances. It was found that accommodation to very near targets (up to 0.20 m) makes the off-axis refraction of myopes wearing their spectacle correction similar to that of lens-free emmetropes, with a significant reduction in off-axis astigmatism observed.
Article
Ophthalmology
Ian G. Beasley, Leon N. Davies, Nicola S. Logan
Summary: The purpose of this study was to investigate whether axial growth and refractive error can be modulated in anisohyperopic children by using multifocal soft contact lenses. The results showed that imposing relative peripheral hyperopic defocus did not accelerate axial growth nor reduce refractive error in anisohyperopic children.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Review
Ophthalmology
Kelsea V. Skidmore, Erin S. Tomiyama, Martin E. Rickert, Kathryn Richdale, Pete Kollbaum
Summary: This study evaluated the relative efficacy of peripheral defocus contact lenses (PDCLs) and orthokeratology (OK) in a real-world clinical population and compared the results with previous randomised controlled clinical trials. The study found no difference in annualised axial length growth between PDCL and OK. These results are consistent with those reported in randomised clinical trials. Therefore, further research is needed to understand the safety and efficacy of these myopia control treatments in the broader population.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Medicine, General & Internal
William Myles, Catherine Dunlop, Sally A. McFadden
Summary: Low-dose atropine can slow the progression of myopia in children, especially in the 'slow' progression group. However, rebound occurred in three-quarters of eyes after cessation of atropine. Adverse effects were observed in 69% of patients, with dilated pupils being more common in children with blue eyes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Jinhua Bao, Yingying Huang, Xue Li, Adeline Yang, Fengchao Zhou, Junqian Wu, Chu Wang, Yuhao Li, Ee Woon Lim, Daniel P. Spiegel, Bjorn Drobe, Hao Chen
Summary: This study found that spectacle lenses with higher lenslet asphericity, especially when worn for longer periods of time, can effectively reduce myopia progression and axial elongation over a two-year period.
JAMA OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Philip R. K. Turnbull, Lucy K. Goodman, John R. Phillips
Summary: This study used gmfERG response amplitudes to compare the differences in central and peripheral retinal responses between dual-focus contact lenses and single-vision lenses. The results showed that dual-focus lenses had higher DC and IC response amplitudes compared to single-vision lenses, with the highest values observed in the central 10 degrees of the retina. This suggests that dual-focus contact lenses slow myopia progression by modifying central rather than peripheral retinal activity.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
Yuzhuo Fan, Yan Li, Kai Wang, Jia Qu, Mingwei Zhao
Summary: This study aims to reproduce the corneal defocus characteristics after Ortho-K treatment and predict its effectiveness. The results show that the size of the weighted defocus is associated with axial length changes, with larger weighted defocus leading to slower elongation.
Article
Biochemical Research Methods
Dibyendu Pusti, Chloe Degre Kendrick, Yifei Wu, Qiuzhi Ji, Hae Won Jung, Geunyoung Yoon
Summary: The quantitative evaluation of peripheral ocular optics is crucial for myopia research and studying visual performance in individuals with normal and compromised central vision. We have developed a widefield scanning wavefront sensor (WSWS) that can scan along any retinal meridian while maintaining natural central fixation. The WSWS utilizes a unique scanning method involving a motorized rotary stage and a goniometer to scan horizontally and vertically, allowing for the evaluation of four meridians within 5 seconds.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Xuewei Li, Jie Hu, Zisu Peng, Sitong Chen, Liyuan Sun, Kai Wang, Yan Li, Mingwei Zhao
Summary: The purpose of this study was to investigate choroidal and ocular biological variables that influence axial length elongation in myopic children wearing defocused incorporated multiple segments spectacle lenses. The results showed that the area of choriocapillaris flow voids and age were significantly associated with axial length elongation. Further analysis indicated that larger choriocapillaris flow voids area, age, and average K reading were associated with axial length elongation. These findings help predict axial elongation in myopic eyes.
Article
Clinical Neurology
Stephanie Mroczkowska, Alexandra Benavente-Perez, Sunni Patel, Lu Qin, Peter Bentham, Doina Gherghel
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2014)
Article
Ophthalmology
Stephanie Mroczkowska, Alexandra Benavente-Perez, Anil Negi, Velota Sung, Sunni R. Patel, Doina Gherghel
JAMA OPHTHALMOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Tatiana Tkatchenko, David Troilo, Alexandra Benavente-Perez, Andrei Tkatchenko
Review
Ophthalmology
Ranjay Chakraborty, Lisa A. Ostrin, Alexandra Benavente-Perez, Pavan Kumar Verkicharla
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2020)
Article
Multidisciplinary Sciences
Alexandra Benavente-Perez, Ann Nour, David Troilo
SCIENTIFIC REPORTS
(2019)
Article
Ophthalmology
Sandeep Kumar, Alexandra Benavente-Perez, Reynolds Ablordeppey, Carol Lin, Suresh Viswanathan, Abram Akopian, Stewart A. Bloomfield
Summary: A robust and reproducible model of glaucoma in the marmoset has been developed, demonstrating structural and functional alterations of the retina and optic nerve characteristic of glaucoma in humans and animal models.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carol Lin, Abduqodir Toychiev, Reynolds Ablordeppey, Nefeli Slavi, Miduturu Srinivas, Alexandra Benavente-Perez
Summary: This study investigated the impact of myopic eye growth on the structure and distribution of astrocytes, vasculature, and retinal nerve fiber layer thickness. The findings showed that in eyes with induced myopia, there were reduced astrocyte numbers, increased GFAP staining, thinner retinal nerve fiber layer, lower peripheral capillary branching, and increased numbers of string vessels. These changes suggest a reorganization of astrocyte and vascular templates during myopia development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiaoying Zhu, Pauline Kang, David Troilo, Alexandra Benavente-Perez
Summary: Studying the temporal integration of visual signals is essential for understanding the impact of different visual tasks on emmetropization and refractive error development. This study examined the effects of interrupting lens-induced defocus with brief periods of unrestricted vision or darkness. The findings suggest that interrupting defocus with normal vision or darkness has different effects on compensation for myopic and hyperopic defocus.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
C. Platzl, A. Kaser-Eichberger, A. Benavente-Perez, F. Schroedl
Summary: This study compared the ultrastructural features of the choroidal scleral transition zone in avian, non-human primate, and human eyes, aiming to confirm the presence of specific mechanical structures. However, no cellular/membrane specializations indicating a mechanical interaction at the choroid-sclera transition zone were detected in chicken, non-human primate or human eyes.
Article
Medicine, General & Internal
Stephanie Mroczkowska, Hala Shokr, Alexandra Benavente-Perez, Anil Negi, Peter Bentham, Doina Gherghel
Summary: The purpose of this study was to compare the retinal microvascular function in patients with mild Alzheimer's disease (AD), early-stage primary open angle glaucoma (POAG), and healthy controls. The results showed that AD and POAG patients had similar alterations in retinal artery reactivity, while healthy controls did not show the same symptoms. Furthermore, there were differences in the reaction time changes between healthy controls and the two disease groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
James S. Wolffsohn, Pete S. Kollbaum, David A. Berntsen, David A. Atchison, Alexandra Benavente, Arthur Bradley, Hetal Buckhurst, Michael Collins, Takashi Fujikado, Takahiro Hiraoka, Masakazu Hirota, Debbie Jones, Nicola S. Logan, Linda Lundstrom, Hidemasa Torii, Scott A. Read, Kovin Naidoo
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Ophthalmology
Ava K. Bittner, Kenneth Seger, Rachel Salveson, Samantha Kayser, Natalia Morrison, Patricia Vargas, Deborah Mendelsohn, Jorge Han, Hua Bi, Gislin Dagnelie, Alexandra Benavente, Jessica Ramella-Roman
ACTA OPHTHALMOLOGICA
(2018)
Article
Ophthalmology
Samantha Kayser, Patricia Vargas, Deborah Mendelsohn, Jorge Han, Hua Bi, Alexandra Benavente, Ava K. Bittner
CURRENT EYE RESEARCH
(2017)
Article
Veterinary Sciences
Tobin V. Ansel, Ann K. Nour, Alexandra Benavente-Perez
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2016)