Article
Oncology
Jankiben R. Patel, Karen M. Gallegos, Rashidra R. Walker, A. Michael Davidson, Ian Davenport, Syreeta L. Tilghman
Summary: The study evaluated the contribution of mammospheres in letrozole-resistant breast cancer, finding that LTLT-Ca tumors expressed CD44(+)/CD24(+) markers, while AC-1 tumors had lower CD44/CD24 expression.
Review
Cell Biology
Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez, Karla Vazquez-Santillan
Summary: Breast cancer stem cells (BCSCs) are a specific subpopulation of cells capable of self-renewal and differentiation into diverse tumor cells. The involvement of cancer stem cells in treatment resistance and cancer recurrence is well established. Specific signaling pathways, such as Wnt/beta-catenin, NF-kappa B, Notch, Hedgehog, TGF-beta, and Hippo, play crucial roles in regulating the self-renewal ability of cancer stem cells. Targeting these signaling pathways holds promise as a therapeutic strategy for combating breast cancer aggressiveness. This review discusses the main signaling pathways involved in maintaining the self-renewal ability of BCSCs and highlights current strategies to disrupt stemness-related signaling molecules.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Fuquan Chen, Xiaomin Li, Xiao Feng, Tingting Gao, Weiyu Zhang, Zhi Cheng, Xuan Zhao, Ruiqing Chen, Xinyi Lu
Summary: In this study, lncRNA Lx8-SINE B2 was identified as a novel regulator of ESC proliferation, cell cycle, and metabolism through working with Eno1.
Review
Medicine, General & Internal
Lorena Alexandra Lisencu, Eduard-Alexandru Bonci, Alexandru Irimie, Ovidiu Balacescu, Cosmin Lisencu
Summary: This review discusses the role of circulating tumor cells (CTCs) in chemoresistance in metastatic breast cancer patients. It highlights that CTCs with stem cell and mesenchymal features are aggressive subtypes that can survive chemotherapy, leading to chemoresistance and disease progression. Hemodynamic shear stress and dynamic changes among CTCs are also important factors in disease progression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Ren Liu, Hack Sun Choi, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee
Summary: In this study, 5-desmethylsinensetin was found to exhibit potential anticancer activity against breast cancer stem cells by targeting the Stat3-IL-6 and Stat3-YAP1 signaling pathways. The compound suppressed proliferation and mammosphere formation of breast cancer cells, reduced subpopulations of specific cancer cells, and inhibited expression of stemness markers.
Review
Oncology
Tong Niu, Weiwei Zhang, Wei Xiao
Summary: Breast cancer stem cells (BCSCs) play critical roles in modulating breast tumor behaviors and drug resistance, while miRNAs in breast cancer exhibit multifaceted roles as suppressors or oncogenes in regulating cancer progression. The review highlights the importance of miRNAs in regulating key signaling pathways that are essential for BCSC maintenance.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
S. S. Hoepner, Ana Raykova, R. Radpour, M. A. Amrein, D. Koller, G. M. Baerlocher, C. Riether, A. F. Ochsenbein
Summary: The study demonstrates that LIGHT and its receptor LT beta R promote quiescence and self-renewal of HSCs, while LT beta R deficiency contributes to survival in a mouse leukemia model.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Jankiben R. Patel, Bipika Banjara, Afia Ohemeng, A. Michael Davidson, Stephen M. Boue, Matthew E. Burow, Syreeta L. Tilghman
Summary: Breast cancer cells that become resistant to letrozole overexpress EGFR, MAPK, and HER2, while also acquiring enhanced motility and EMT-like characteristics, which can be attenuated and reversed by glyceollin treatment. Glyceollin inhibits the proliferation and tumor progression of TNBC and estrogen-independent breast cancer cells, but it may not effectively target AI-resistant metastatic breast cancer in clinical settings. Combination therapy of glyceollin and lapatinib induces apoptosis in hormone-dependent AI-resistant breast cancer cells, and it may also be beneficial for letrozole-resistant breast cancer cells by decreasing proliferation and cell cycle progression-associated proteins. This unique opportunity could lead to the development of novel combination therapies for hormone-refractory breast tumors.
Article
Cell & Tissue Engineering
Haiqing Luo, Chih-Yu Chen, Xiangyong Li, Xin Zhang, Chien-Wen Su, Yinghua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing X. Kang
Summary: Aberrant lipid metabolism is recognized as a new hallmark of malignancy, and targeting specific enzymes involved in fatty acid metabolism can limit self-renewal and growth of breast cancer stem cells. Omega-3 fatty acids are effective in suppressing lipogenic enzymes and reducing tumor load in BCSC-derived tumors.
Article
Cell Biology
Xiaomin Du, Siyu Wu, Yudong Wei, Xiuwei Yu, Fanglin Ma, Yuanxin Zhai, Donghui Yang, Mengfei Zhang, Wenqing Liu, Haijing Zhu, Jiang Wu, Mingzhi Liao, Na Li, Chunling Bai, Guangpeng Li, Jinlian Hua
Summary: The study identified a subset of spermatogonial stem cells in dairy goats with high PAX7 expression, indicating that PAX7 can maintain the self-renewal of these cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell & Tissue Engineering
Cong Zhao, Wen Xie, Hecheng Zhu, Ming Zhao, Weidong Liu, Zhaoping Wu, Lei Wang, Bin Zhu, Shasha Li, Yao Zhou, Xingjun Jiang, Qiang Xu, Caiping Ren
Summary: Stem cells are unique cells with the ability to self-renew and differentiate into various functional cells. Recent studies have revealed the crucial roles of long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) in the self-renewal and differentiation of stem cells. This review summarizes the functions of lncRNAs and their RBPs in determining the fate of stem cells, focusing on their involvement in epigenetic regulation, signaling pathway regulation, splicing, mRNA stability, and subcellular localization. Understanding the regulatory mechanisms of lncRNAs and RBPs will contribute to the development of clinical regenerative medicine.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Chandler W. Jensen-Cody, Adrianne K. Crooke, Pavana G. Rotti, Vitaly Ievlev, Weam Shahin, Soo-Yeun Park, Thomas J. Lynch, John F. Engelhardt
Summary: The transcription factor Lef-1 plays a crucial role in regulating proliferation and differentiation of mouse tracheal basal cells. The deletion of Lef-1 leads to cell cycle arrest, downregulation of key genes related to DNA damage response and cell cycle progression, affecting basal cell self-renewal and tracheal epithelium regeneration. The study suggests that modulating Lef-1 function in airway basal cells may have potential applications in regenerative medicine.
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Fu-Sheng Chou, Chu-Yen Chen, An-Chun Lee, Pei-Shan Wang
Summary: Individuals with intrauterine growth restriction (IUGR) are at an increased risk for neurodevelopmental impairment. This study used a murine maternal hypoxia-induced IUGR model to investigate its impact on fetal neural stem cell (NSC) development. It was found that IUGR is associated with a defect in the cell cycle progression of fetal NSCs, leading to a decrease in the number of layer-specific neurons. However, the newly generated neurons in IUGR still maintain their temporal identity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuso Takeda, Masayo Hirao-Suzuki, Mitsuru Shindo, Hironori Aramaki
Summary: This study demonstrates that (-)-xanthatin is able to kill mammospheres of breast cancer CSCs, indicating a potential anti-proliferative mechanism.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)