Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

(2009) Pierfausto Seneci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

(2009) M. Vogler et al.   CANCER RESEARCH

Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family

(2009) Federica Cossu et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics

(2008) Haiying Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

(2008) M. Fakler et al.   BLOOD

TRAIL-induced apoptosis of HL60 leukemia cells: Two distinct phenotypes of acquired TRAIL resistance that are accompanied with resistance to TNFα but not to idarubicin and cytarabine☆

(2008) P KLENERJR et al.   BLOOD CELLS MOLECULES AND DISEASES

Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis

(2008) V Bilim et al.   BRITISH JOURNAL OF CANCER

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

(2008) J. Lu et al.   CANCER RESEARCH

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases

(2008) Bin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitor of apoptosis proteins in hematological malignancies

(2008) S Fulda   LEUKEMIA

A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma

(2008) O Ndozangue-Touriguine et al.   ONCOGENE