期刊
INVERTEBRATE NEUROSCIENCE
卷 10, 期 1, 页码 5-10出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10158-010-0105-y
关键词
Anaesthetic; Anthelmintic; Glutamate-gated chloride channel; Glycine receptor; Insecticide; Nicotinic receptor
Avermectins and milbemycins are an important family of anthelmintics, insecticides and acaricides. Their mode of action is as positive allosteric modulators of ligand-gated chloride channels, and at higher concentrations, they gate some channels directly. Though it has long been known that the avermectins do not compete for the ligand binding site, the actual site at which they interact with their receptors has been unclear. Recent data demonstrate the importance to drug binding of amino acid residues predicted to line a water-filled pocket in the channel domain. This pocket acts as the binding site for anaesthetics and other modulators of mammalian GABA(A) and glycine receptors, suggesting similarities in the mode of action between these drugs and the avermectins/milbemycins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据