Article
Clinical Neurology
Huaping Du, Tingting Guo, Huan Ye, Yingshi Bao, Zhuoyin Qiu, Yaming Sun, Shoujiang You, Yuan Liu, Yuan Xu, Chunqing Zhang, Chunfang Qiu
Summary: An elevated concentration of serum phosphorus is associated with carotid atherosclerosis in ischemic stroke patients, as measured by cIMT.
FRONTIERS IN NEUROLOGY
(2023)
Review
Health Care Sciences & Services
Anna Maria Rychter, Dariusz Naskret, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Atherosclerosis is strongly associated with obesity, with carotid intima-media thickness (cIMT) serving as a predictor of cardiovascular events and subclinical atherosclerosis. Behavioral interventions can directly impact cIMT values, influencing cardiovascular disease risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Hematology
Matthew J. Feinstein, Margaret F. Doyle, James H. Stein, Colleen M. Sitlani, Alison E. Fohner, Sally A. Huber, Alan L. Landay, Susan R. Heckbert, Kenneth Rice, Richard A. Kronmal, Catherine Hedrick, Ani Manichaikul, Coleen McNamara, Stephen Rich, Russell P. Tracy, Nels C. Olson, Bruce M. Psaty, Joseph A. C. Delaney
Summary: This study investigated the associations of myeloid and lymphoid cell subsets with cardiovascular disease onset and progression, finding that nonclassical monocytes were associated with progression of carotid IMT. Significant sex differences were observed in the associations of monocyte subsets with IMT progression, with different patterns between men and women.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sophia J. Kiechl, Anna Staudt, Katharina Stock, Nina Gande, Benoit Bernar, Christoph Hochmayr, Bernhard Winder, Ralf Geiger, Andrea Griesmacher, Markus Anliker, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Raimund Pechlaner
Summary: The study revealed that systolic blood pressure, arterial hypertension, low-density and non-high-density lipoprotein cholesterol, and alanine transaminase predicted cIMT progression in adolescents, even when risk factor levels were within established reference ranges. These findings underline the importance of initiating prevention early in life and question the current focus on high-risk youngsters in guideline recommendations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Po-Chih Lin, Chung-Yen Chen, Charlene Wu, Ta-Chen Su
Summary: This study investigated subclinical carotid atherosclerosis in patients with familial hypercholesterolemia (FH) and their family members, and found that systemic inflammation synergistically contributed to atherogenic dyslipidemia on subclinical atherosclerosis.
Article
Biochemistry & Molecular Biology
Alexander Balatskiy, Marina Teterina, Alexandra Pisaryuk, Irina Balabanenko, Alexey Kadrev, Anastasia Tishuk, Maria Balatskaya, Larisa Samokhodskaya, Sergey Boytsov, Natalia Kalinina, Vsevolod Tkachuk
Summary: The study found an inverse correlation between carotid artery IMT and HMW levels in male subjects. The G allele of rs12444338 SNP in the T-cadherin gene was associated with lower levels of circulating T-cadherin and thinner IMT, suggesting a potential atheroprotective genotype.
Article
Cardiac & Cardiovascular Systems
Evangelos Oikonomou, George Lazaros, Vasiliki Chara Mystakidi, Nikolaos Papaioannou, Panagiotis Theofilis, Georgia Vogiatzi, Christos Chasikidis, Petros Fountoulakis, Maria-Argentina Papakostantinou, Margarita Niki Assimakopoulos, Nikolaos Barmparesos, Panagiotis Tasios, Juan C. Kaski, Dimitris Tousoulis
Summary: The study demonstrates that residents in areas with high concentrations of gaseous air pollutants have increased carotid atherosclerotic burden and inflammation compared to residents in other regions. High levels of CO, NO2, and SO2 were observed in Region 4, where individuals also showed higher levels of C reactive protein and greater carotid plaque burden. Additionally, the propensity score analysis indicated higher differences in mean cIMT among individuals with coronary artery disease in high pollution areas compared to low pollution areas.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Karri Parkkila, Antti Kiviniemi, Mikko Tulppo, Juha Perkiomaki, Y. Antero Kesaniemi, Olavi Ukkola
Summary: This study found that carotid and femoral bruits do not provide clinically useful information in a pure primary prevention setting. However, carotid bruits may be useful in evaluating the overall cardiovascular risk in a population where recurrent cardiovascular events may occur.
Article
Biochemistry & Molecular Biology
Valeria Sutti Nunes, Edite Vieira Silva de Campos, Jamal Baracat, Victor Franca, Erica Ivana Lazaro Gomes, Raissa Peres Coelho, Edna Regina Nakandakare, Vanessa Helena Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintao
Summary: This study investigated the relationships between plasma cholesterol synthesis and absorption markers and cardiovascular disease risk factors, cIMT, and carotid plaques in asymptomatic subjects. The findings suggested that campesterol may be associated with atherosclerotic plaques, while the ratios of lathosterol/campesterol or lathosterol/sitosterol may indicate an inverse association. This highlights the inverse relationship between cholesterol synthesis and absorption, with the absorption marker campesterol reflecting changes in body cholesterol homeostasis and atherosclerotic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vaishali Narendra Naik, R. S. Gamad, P. P. Bansod
Summary: This study investigates the effects of three despeckle filters on the segmentation of carotid IMT in ultrasound images. The results show that the median filter performs better than the hybrid median and IACDF filters.
BIOMEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Karsten Konigstein, Julia Charlotte Buschges, Giselle Sarganas, Susanne Krug, Hannelore Neuhauser, Arno Schmidt-Trucksass
Summary: This study found that exercise can reduce cardiovascular risk in young individuals, but has little effect on carotid structure and function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Yue Leon Guo, Rosario D. Ampon, Ivan C. Hanigan, Luke D. Knibbs, Christy Geromboux, Ta-Chen Su, Kazuaki Negishi, Leanne Poulos, Geoffrey G. Morgan, Guy B. Marks, Bin Jalaludin
Summary: The study found that long-term exposure to low levels of PM2.5 in children may have measurable adverse impacts on cardiovascular risk marker, carotid intima-media thickness (CIMT), by age 11-12 years.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Ji Bian, Man Zhang, Feng Li, Jie Gao, Zhexue Wei, Zijing Liu, Xiaoming Wang, Wen Jiang, Jianchao Bian
Summary: Excess iodine intake has been shown to increase the risk of carotid intima-media thickening, potentially leading to vascular injury and atherosclerosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Endocrinology & Metabolism
J. J. Drinkwater, F. K. Chen, A. M. Brooks, B. T. Davis, A. W. Turner, T. M. E. Davis, W. A. Davis
Summary: This study found an independent association between macrovascular disease and arterial stiffness with diabetic retinopathy in patients with type 2 diabetes. The occurrence of diabetic retinopathy is closely related to patients' age at diagnosis, blood glucose control level, treatment method, and cardiovascular health.
Article
Peripheral Vascular Disease
Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N. Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa
Summary: This study investigated the association between lung function and carotid intima-media thickness (cIMT) in the Japanese population. The results showed that lower lung function was associated with higher cIMT, regardless of smoking status or age group. This study highlights the importance of assessing atherosclerosis or lung function in individuals with lower lung function or atherosclerosis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Toxicology
Sana Sungur, Mutasim Ciran, Muaz Koroglu, F. Hilmi Turgut
Summary: Phthalates are commonly used man-made chemicals with adverse health effects, and this study analyzed the phthalate content in commonly used drugs in China and evaluated the potential health risks for patients. The results showed that the phthalate concentrations in the examined drug samples did not pose a risk to human health.
Article
Transplantation
Priya Vart, Raphael Duivenvoorden, Casper F. M. Franssen, Marc H. Hemmelder, Kitty J. Jager, Luuk B. Hilbrands, Marlies Noordzij, Daniel Abramowicz, Carlo Basile, Adrian Covic, Marta Crespo, Ziad A. Massy, Alberto Ortiz, J. Emilio Sanchez, Emily Petridou, Colin White, Ron T. Gansevoort
Summary: Due to the vulnerability of chronic kidney disease patients to infectious diseases, the COVID-19 pandemic has had a devastating impact on the nephrology community. Lessons from the European Renal Association COVID-19 Database project provide recommendations for improving preparedness for future health crises. Challenges faced include limited collaboration, lack of common data architecture, and sub-optimal data quality. Aligning research initiatives, strengthening electronic health records, and involving experts in study design and data analysis will be crucial in responding to the next pandemic.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Alferso C. Abrahams, Marlies Noordzij, Eric Goffin, J. Emilio Sanchez, Casper F. M. Franssen, Priya Vart, Kitty J. Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H. Hemmelder, Raphael Duivenvoorden, Luuk B. Hilbrands, Ron T. Gansevoort
Summary: This study analyzed the clinical course and outcomes of COVID-19 in a group of PD patients and found that PD patients had a higher mortality rate compared to HD patients. Most COVID-19 survivors achieved functional and mental recovery within 3 months.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Faruk Turgut, Alaa S. S. Awad, Emaad M. M. Abdel-Rahman
Summary: Acute kidney injury (AKI) is a common clinical syndrome characterized by a sudden decline in or loss of kidney function. It is associated with substantial morbidity, mortality, and increased risk of chronic kidney disease (CKD). The classification of AKI into prerenal, intrarenal, and postrenal categories may be useful for differential diagnosis, but AKI is mostly multifactorial, with various pathophysiologic features. Acute tubular necrosis, caused by ischemia or nephrotoxicity, is common in AKI. Identifying AKI in a timely manner and understanding the mechanisms behind kidney dysfunction are crucial. This review discusses the medical causes and recent updates in the pathogenesis of AKI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Peter J. Blankestijn, Robin W. M. Vernooij, Carinna Hockham, Giovanni F. M. Strippoli, Bernard Canaud, Joergen Hegbrant, Claudia Barth, Adrian Covic, Krister Cromm, Andrea Cucui, Andrew Davenport, Matthias Rose, Marietta Torok, Mark Woodward, Michiel L. Bots
Summary: This study suggests that high-dose hemodiafiltration is more beneficial for patients with kidney failure compared to standard hemodialysis. A randomized controlled trial involving 1360 patients showed that those who received high-dose hemodiafiltration had a lower risk of death.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Clinical Neurology
Mehmet Kanbay, Carina Ureche, Sidar Copur, Alexandra M. M. Covic, Cem Tanriover, Bugra H. H. Esen, Mert Sekmen, Asiye Kanbay, Adrian Covic
Summary: Obstructive sleep apnea (OSA) is common in patients with chronic kidney disease and can lead to serious complications. Kidney transplantation does not have a significant effect on the progression of OSA.
SLEEP AND BREATHING
(2023)
Article
Medicine, General & Internal
Carina Ureche, Gianina Dodi, Alexandra Covic, Alina Nedelcu, Simona R. Volovat, Radu A. Sascau, Cristian Statescu, Adrian Covic
Summary: This study aimed to determine the association between echocardiographic parameters and biomarkers of cardiac fibrosis in patients with end-stage renal disease. The results showed a significant correlation between echocardiographic parameters and biomarkers, especially a strong association between the collagen-derived biomarker PICP and cardiac function indicators.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Luminita Voroneanu, Alexandru Burlacu, Crischentian Brinza, Andreea Covic, Gheorghe G. Balan, Ionut Nistor, Cristina Popa, Simona Hogas, Adrian Covic
Summary: This study systematically reviewed the gut microbiota composition in patients with chronic kidney disease (CKD). The results showed that CKD patients had decreased microbiota diversity and decreased abundance of Roseburia. Gut dysbiosis was also associated with peritonitis and enhanced inflammatory activity. Additionally, synbiotic and probiotic therapies were found to have a beneficial effect on gut flora composition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Titus Andrian, Lucian Siriteanu, Andreea Simona Covic, Cristina Alexandra Ipate, Adelina Miron, Corneliu Morosanu, Irina-Draga Caruntu, Adrian Covic
Summary: Rates of late allograft loss have improved slowly in the last decades. Well described traditional risk factors that influence allograft survival include cardiovascular events, rejection, infections and post-transplant neoplasia. Here, we critically evaluate the influence of several non-immunological, non-traditional risk factors and describe their impact on allograft survival and cardiovascular health of kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Huseyin Erdal, Faruk Turgut
Summary: This study is the first to examine the thiol-disulfide balance and oxidative stress levels in patients with Fabry disease. The results show significant differences in thiol and disulfide levels between the patient and control groups, and these levels are correlated with lysosomal globotriaosylceramide, total oxidant status, and blood urea nitrogen. Additionally, the study found lower total antioxidant status and higher oxidative stress levels in Fabry disease patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Review
Transplantation
Mehmet Kanbay, Sidar Copur, Abdullah B. Yildiz, Andreea Covic, Adrian Covic, Paola Ciceri, Lorenza Magagnoli, Mario Cozzolino
Summary: Multiple risk factors for chronic kidney disease have been identified, and prematurity and intrauterine growth restriction (IUGR) have been associated with an increased risk for CKD. This review aims to evaluate the association between CKD risk and prematurity, low birthweight, and IUGR, along with potential underlying pathophysiological mechanisms.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Transplantation
Mehmet Kanbay, Carlo Basile, Yuri Battaglia, Alessandro Mantovani, Furkan Yavuz, Francesco Pizzarelli, Valerie A. Luyckx, Adrian Covic, Vassilios Liakopoulos, Sandip Mitra, EuDial Working Group of ERA
Summary: The definition of the elderly as individuals aged 65 years or older fails to consider the genetic, lifestyle, and overall health differences that contribute to significant heterogeneity among older adults. With the global aging population, the prevalence of chronic diseases, including chronic kidney disease (CKD), is increasing. Frailty is highly prevalent in this population and needs to be assessed to inform medical decisions. Choosing the optimal treatment pathway for elderly and frail patients with kidney failure is complex due to the presence of comorbidities associated with low survival rates and impaired quality of life. Multidisciplinary management involving healthcare professionals from various specialties is recommended. Current studies are mainly retrospective and observational, and lack adjustment for confounders or addressing biases, making it difficult to guide treatment decisions. Prospective studies and systematic reviews are needed to address these issues.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Alexandru Burlacu, Mariana Floria, Crischentian Brinza, Adrian Covic
Summary: This meta-analysis aimed to compare the efficacy and safety endpoints of ticagrelor and clopidogrel in end-stage kidney disease (ESKD) patients on chronic dialysis presenting with acute or chronic coronary syndromes (ACS or CCS). The results showed no significant difference in efficacy or safety outcomes between ticagrelor and clopidogrel. Further randomized controlled trials are needed to establish the optimal antiplatelet therapy in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Umran Gezici Gunes, Faruk Turgut, Huseyin Erdal, Serdar Dogan
Summary: The study aimed to investigate the relationship between plasma apelin concentrations, oxidative stress biomarkers, and albuminuria in patients with type 2 diabetes mellitus. The results showed significantly decreased serum apelin concentrations and thiol levels in patients with type 2 diabetes. A negative correlation was found between serum apelin concentrations and glycemic control, as well as between thiol levels and albumin.
TURKISH JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Adelina Miron, Ionut Nistor, Corneliu Morosanu, Lucian Siriteanu, Adrian Covic
Summary: This study investigated the prevalence and impact of erectile dysfunction (ED) after kidney transplantation. The results showed that the prevalence of sexual dysfunction increased with age, and only a small percentage of patients had a normal sexual function. Additionally, the use of alpha-blockers and aspirin was associated with ED.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
