Review
Immunology
Shahram Solaymani-Mohammadi
Summary: Human giardiasis is a common parasitic disease that can lead to malnutrition and developmental disorders. Understanding the interaction between the parasite and the intestinal epithelial cells may provide insights into the pathology and help identify new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongyu Xiao, Hailun Li, Yifan Wen, Dongxu Jiang, Shumin Zhu, Xueling He, Qingping Xiong, Jie Gao, Shaozhen Hou, Song Huang, Lian He, Jian Liang
Summary: TFP shows significant therapeutic effects on DSS-induced UC model by inhibiting inflammation and restoring intestinal barrier and mucus barrier function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Bingyu Wang, Zhiqiang Gong, Jingyu Zhan, Lei Yang, Quanyu Zhou, Xingxing Yuan
Summary: Xianglian pill (XLP) has been found to alleviate DSS-induced acute colitis in mice by inhibiting pro-inflammatory cytokines secretion, repairing intestinal epithelial barrier dysfunction, enhancing autophagy, and blocking the activation of the PI3K/Akt/mTOR pathway. Blocking autophagy attenuated the protective effects of XLP on colitis, suggesting that the underlying mechanism may involve Xianglian pill promoting autophagy by blocking the activation of the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kehan Rao, Shumin Qin, Yuanming Yang, Kai Zhan, Haomeng Wu, Huan Zheng, Shaogang Huang
Summary: The study found that shenling baizhu powder (SBP) has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis. SBP effectively strengthens the epithelial barrier integrity in colitis patients by increasing the secretion of mucin and tight junction proteins while inhibiting apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Sandra Chanez-Paredes, Armando Montoya-Garcia, Karla F. Castro-Ochoa, Julio Garcia-Cordero, Leticia Cedillo-Barron, Mineko Shibayama, Porfirio Nava, Sven Flemming, Nicolas Schlegel, Alexis M. Gautreau, Hilda Vargas-Robles, Ricardo Mondragon-Flores, Michael Schnoor
Summary: The Arp2/3 inhibitory protein arpin plays a crucial role in maintaining the integrity of the intestinal epithelial barrier (IEB) and its expression is regulated by inflammatory factors. Lower levels of arpin can trigger dysfunction of IEB during inflammation. Treatment with the Arp2/3-specific inhibitor CK666 can alleviate inflammation-induced permeability barriers, suggesting a potential therapeutic strategy for IEB-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Biochemistry & Molecular Biology
Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrandiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesus Cosin-Roger
Summary: This study found that the succinate receptor SUCNR1 plays a role in both basal and stimulated inflammatory pathways in intestinal epithelial cells. It is significantly involved in inflammasome activation in Ulcerative Colitis (UC).
Article
Pharmacology & Pharmacy
Zhiwei Miao, Liping Chen, Hui Feng, Mingjia Gu, Jing Yan, Yi Xu, Bai Ye
Summary: The study found that BTW significantly suppressed intestinal inflammation in UC mice, potentially through regulating the balance of Th17/Treg cells and restoring the intestinal epithelial barrier.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Bing Li, Yan Li, Lixiang Li, Yu Yu, Xiang Gu, Chang Liu, Xin Long, Yanbo Yu, Xiuli Zuo
Summary: This study identified dysregulated circRNAs and miRNAs in the colon tissue of UC patients compared to healthy controls. One specific circRNA, hsa_circ_0001021, was significantly downregulated in UC patients and may serve as a potential therapeutic target for regulating healthy intestinal function by sponging miR-224-5p.
Article
Gastroenterology & Hepatology
Luca Massimino, Orazio Palmieri, Amanda Facoetti, Davide Fuggetta, Salvatore Spano, Luigi Antonio Lamparelli, Silvia D'Alessio, Stefania Cagliani, Federica Furfaro, Ferdinando D'Amico, Alessandra Zilli, Gionata Fiorino, Tommaso Lorenzo Parigi, Daniele Noviello, Anna Latiano, Fabrizio Bossa, Tiziana Latiano, Alessandra Pirola, Luca Mologni, Rocco Giovanni Piazza, Danilo Abbati, Francesco Perri, Chiara Bonini, Laurent Peyrin-Biroulet, Alberto Malesci, Vipul Jairath, Silvio Danese, Federica Ungaro
Summary: This study found that the virome-associated protein encoded by the hepatitis B virus (HBx) is detected in about 45% of patients with ulcerative colitis (UC) and is associated with UC progression. Experimental findings showed that HBx induces colonic inflammation and its silencing reverses the colitis phenotype. HBx acts as a transcriptional regulator in epithelial cells, leading to barrier leakage and altering mucosal immunity. This study provides a new perspective on targeted treatments for the virome composition of the gut microbiota.
Article
Pharmacology & Pharmacy
Yaying You, Yongtao Xiao, Ying Lu, Jun Du, Hui Cai, Wei Cai, Weihui Yan
Summary: The pathogenesis of IBD is complicated and still unclear. This study found that through the activation of NOD2 and MDP, gut inflammation can be alleviated and intestinal barrier repair can be promoted by regulating autophagy in intestinal epithelial cells, reducing intestinal barrier damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aurora Mazzei, Grazia Serino, Alessandro Romano, Emanuele Piccinno, Viviana Scalavino, Anna Maria Valentini, Raffaele Armentano, Roberta Schiavone, Gianluigi Giannelli, Tiziano Verri, Amilcare Barca
Summary: SLC15A4/PHT1 has been identified as a key path marker of immune/autoimmune/inflammatory pathways in immune cells, and this study found its overexpression in the colonic epithelium of ulcerative colitis (UC) patients. In vitro experiments successfully mirrored the inflammatory onset in spontaneously differentiated enterocyte-like monolayers of Caco-2 cells specifically exposed to DSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Meishan Yue, Jialu Huang, Xiaolan Ma, Peng Huang, Yisong Liu, Jianguo Zeng
Summary: This study found that PRO, an anti-inflammatory ingredient in Macleaya cordata, can alleviate inflammation symptoms and restore the intestinal barrier in DSS-induced colitis mice. PRO also regulates the composition of gut microbiota.
Article
Nutrition & Dietetics
Min Guo, Dehai Xing, Jin Wang, Ying Zhang, Zhuoyu Li, Xiangying Jiao
Summary: Ulcerative colitis (UC) is a growing burden globally, especially in developing countries. This study investigated the effect of N. commune polysaccharides on acute colitis in mice induced by DSS and its role in mediating the gut microbiota. The results showed that N. commune polysaccharides enhanced the intestinal mucosal barrier and exhibited prebiotic-like functions, suggesting its potential as an alternative or complementary treatment for UC.
Article
Biochemistry & Molecular Biology
Xiaohan Wu, Shuchun Wei, Meilin Chen, Jinting Li, Yuping Wei, Jixiang Zhang, Weiguo Dong
Summary: P2Y13 is highly expressed in ulcerative colitis and can aggravate intestinal mucosal barrier destruction by activating the IL-6/STAT3 pathway, making it a potential drug target for UC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Food Science & Technology
Liyi Wang, Ziye Xu, Defeng Ling, Jie Li, Yizhen Wang, Tizhong Shan
Summary: This article summarizes and discusses the roles of various dietary factors in regulating skeletal muscle development and function, and reviews their potential regulatory molecular mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Cheng Wang, Siyu Wei, Nana Chen, Yun Xiang, Yizhen Wang, Mingliang Jin
Summary: This study investigated the gut microbiota characteristics in 120 pigs of different breeds, growth periods, and genders, revealing that gut microbiota plays important roles in nutrition, metabolism, and immunity. The top 10 most abundant genera accounted for 66.53% of the microbiota, and 28 common species were identified. The explanatory effects of influencing factors suggested that growth period was the greatest contributor to the gut microbiota in pigs.
MICROBIAL BIOTECHNOLOGY
(2022)
Review
Nutrition & Dietetics
Bocheng Xu, Jinping Cao, Jie Fu, Zhi Li, Mingliang Jin, Xinxia Wang, Yizhen Wang
Summary: This meta-analysis examined the effects of nondigestible fermentable carbohydrates (NDFCs) on adiposity and cardiovascular risk factors in adults with overweight or obesity. The findings suggest that increased intake of NDFCs is significantly effective in reducing body weight, waist and hip circumference, blood pressure, cholesterol levels, and low-density lipoprotein in individuals with overweight and obesity.
Article
Biochemistry & Molecular Biology
Jinping Cao, Xin Liu, Yuanzhi Cheng, Yizhen Wang, Fengqin Wang
Summary: The study found that supplementation of SeEPS significantly improved the average daily weight gain and reduced the feed-to-gain ratio of mice, without causing liver damage. SeEPS supplementation also enhanced antioxidant capacity in the liver and serum, as well as regulated selenium deposition in mice.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biology
Wei Chen, Yushi Chen, Ruifan Wu, Guanqun Guo, Youhua Liu, Botao Zeng, Xing Liao, Yizhen Wang, Xinxia Wang
Summary: This study found that DHA can promote mitochondrial biogenesis and skeletal muscle fiber remodeling through the FTO/m(6)A/DDIT4/PGC1 alpha signaling pathway, protecting against obesity-induced decline in skeletal muscle function.
Article
Biochemistry & Molecular Biology
Lixia Kai, Xin Zong, Qin Jiang, Zeqing Lu, Fengqin Wang, Yizhen Wang, Tenghao Wang, Mingliang Jin
Summary: The water-soluble polysaccharides AMP from Atractylodes macrocephalae Koidz. have protective effects on intestinal mucosal barrier injury induced by DSS in mice. AMP alleviates body weight decreases, shortens colon length, ameliorates colonic damage, decreases proinflammatory cytokines, and modulates intestinal microbiota to increase beneficial bacteria ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Luoyi Zhu, Xin Zong, Xiao Xiao, Yuanzhi Cheng, Jie Fu, Zeqing Lu, Mingliang Jin, Fengqin Wang, Yizhen Wang
Summary: Liver injury in colitis mice may be related to intestinal dysbiosis and host-microbiota interactions, as revealed by an integrated analysis of host transcriptome and colonic microbiome. The liver and colon transcriptome showed significant changes, and genes associated with liver injury were correlated with the abundance of liver and gut health-related bacteria. These findings provide new insights for potential targets in the treatment of IBD and its induced liver injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Luoyi Zhu, Jie Fu, Xiao Xiao, Fengqin Wang, Mingliang Jin, Weihuan Fang, Yizhen Wang, Xin Zong
Summary: The study found that Faecal Microbiota Transplantation (FMT) can prevent high-fat diet-induced obesity and lipid metabolism disorders by altering the jejunal microbiota composition and increasing the abundance of Lactobacillus and Romboutsia, which are negatively correlated with obesity-related indicators. The anti-obesity effect of wild boar faecal suspension is associated with jejunal N6-methyladenosine (m(6)A) levels. Overall, these results suggest that FMT has a mitigating effect on HFD-induced obesity by altering microbial composition and structure of the jejunum.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xing Liao, Jiaqi Liu, Yushi Chen, Youhua Liu, Wei Chen, Botao Zeng, Yuxi Liu, Yaojun Luo, Chaoqun Huang, Guanqun Guo, Yizhen Wang, Xinxia Wang
Summary: This study found that metformin can combat obesity by inhibiting adipogenesis and regulating the cell cycle, leading to significant weight loss and decreased adipose tissue weight.
JOURNAL OF DRUG TARGETING
(2022)
Review
Immunology
Weifa Su, Tao Gong, Zipeng Jiang, Zeqing Lu, Yizhen Wang
Summary: Early weaning is important for improving sow production efficiency, but often leads to postweaning diarrhea (PWD) in piglets. Traditional antibiotic supplementation has drawbacks, while probiotics have shown potential for preventing and treating PWD by regulating intestinal barriers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Cheng Wang, Siyu Wei, Bojing Liu, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang
Summary: Research has found that a maternal fermented diet can improve the performance of sows and piglets, accelerate the maturation of neonatal gut microbiota, and reduce susceptibility to colonic inflammation in offspring. Milk L-glutamine and gut Lactobacillus were identified as important factors in the fermented diet, which can modulate the gut microbiota and alleviate inflammation.
Article
Nutrition & Dietetics
Cheng Wang, Siyu Wei, Mingliang Jin, Bojing Liu, Min Yue, Yizhen Wang
Summary: The present study investigated the dynamics of microbiota and metabolites during solid-state fermentation of plant-based food using two-stage fermentation. It revealed the changes in predominant bacteria and metabolic pathways at different fermentation stages, with phenylalanine metabolism identified as the most important pathway. The correlations between microbiota and metabolites were also analyzed, showing significant associations between specific bacteria and amino acid metabolism.
FRONTIERS IN NUTRITION
(2022)
Article
Veterinary Sciences
Zipeng Jiang, Weifa Su, Chaoyue Wen, Wentao Li, Yu Zhang, Tao Gong, Shuai Du, Xinxia Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang
Summary: Clostridium perfringens is a main pathogen that can cause various diseases in humans and animals. This study aimed to build a mouse model infected with porcine C. perfringens and investigated its effects on growth performance, immune status, and intestinal integrity in mice. The results showed that high dose of C. perfringens caused a decline in growth performance, severe damage to intestinal structure, and increased inflammation in mice.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Weike Shaoyong, Yalin Liu, Bocheng Xu, Bo Pan, Xinuer Xianmi, Yizhen Wang, Mingliang Jin
Summary: This study found that exposure to BDE-47 can cause ovarian lipid deposition and hormone disruption accompanied by oxidative stress and downregulation of hormone biosynthesis-related proteins. Using a cellular model, it was shown that BDE-47 inhibits ovarian hormone secretion by interfering with specific pathways and inducing endoplasmic reticulum stress, mitochondrial abnormalities, and lipotoxicity. The findings suggest potential health risks of BDE-47 pollution areas to women, particularly affecting their ovarian hormone secretion.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cell Biology
Ziye Xu, Wentao Chen, Liyi Wang, Wenjing You, Yanfang Wang, Yizhen Wang, Jianguo Zhao, Tizhong Shan
Summary: This study investigated the lipid profiles and regulatory pathways in the skeletal muscles of UCP1 KI pigs using lipidomics and transcriptomics. The results showed altered contents of glycerophospholipids and acyl carnitines in UCP1 KI skeletal muscles, as well as enriched metabolic regulatory pathways. Comparison of transcriptomes suggested a possible crosstalk between adipose and skeletal muscle tissues through nervous system or chemokine signaling in UCP1 KI pigs. Additionally, associations between UCP1 KI-induced metabolic alterations and metabolic and muscle dysfunction were identified using lipid biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)