Article
Immunology
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: Activation of TRPV4 can negatively regulate bladder inflammation induced by LPS and alleviate bladder hypersensitivity. This finding may provide new therapeutic targets for refractory bladder pain syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Masaru Yoshizumi, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: This study established a chronic cystitis model in rats using LPS and investigated the effects of gabapentin on bladder hypersensitivity. The results showed that LPS injections induced long-lasting bladder inflammation, pain, and overactivity in the rats, while gabapentin effectively managed these symptoms in the chronic cystitis model.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Jayoung Kim, Amanda De Hoedt, Emily Wiggins, Kelsey Haywood, Peng Jin, Bennett Greenwood, Niven R. Narain, Vladimir Tolstikov, Valerie Bussberg, Kamil E. Barbour, Michael A. Kiebish, Stephen J. Freedland, Jennifer T. Anger
Summary: The study aimed to identify potential biomarkers of interstitial cystitis/painful bladder syndrome (IC) by analyzing urine and serum metabolomes of IC patients and non-disease controls. The analysis revealed distinct metabolomic profiles in IC patients, with specific markers identified in urine samples. Integrated analyses of key metabolites showed promising biomarkers for the pathophysiology of IC.
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Robert M. Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J. Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R. Rilo, Edmund J. Miller, Souhel Najjar, Inna Tabansky, Joel N. H. Stern
Summary: Interstitial cystitis/bladder pain syndrome patients with Hunner lesions (HL) show local inflammatory events and increased levels of immune cells. Urinary levels of different cytokines are also elevated in HL patients, indicating different disease processes compared to patients without HL.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hsueh-Yu Mu, Ming-Ping Wu, I-Te Wang, Jeng-Cheng Wu, Hung-Yen Chin
Summary: Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are two lower urinary tract disorders with overlapping symptoms, making it difficult to accurately differentiate between them. This study identified a subgroup of OAB patients with bladder pain (OAB-BP) that could be distinguished from those with OAB alone through urodynamic study (UDS) findings. The clinical presentations and urodynamic parameters of OAB-BP and IC/PBS were found to be more similar than those of OAB alone.
Article
Nursing
Angela Kirkham, Katherine Swainston
Summary: This study aimed to explore the lived experience of IC/PBS, revealing issues in diagnosis, restrictions on life, self-management, as well as interpersonal relationships and social support faced by patients.
WESTERN JOURNAL OF NURSING RESEARCH
(2022)
Article
Medicine, General & Internal
Pedro-Santiago Borrego-Jimenez, Javier Flores-Fraile, Barbara-Yolanda Padilla-Fernandez, Sebastian Valverde-Martinez, Agustin Gomez-Prieto, Magaly Teresa Marquez-Sanchez, Jose-Antonio Miron-Canelo, Maria-Fernanda Lorenzo-Gomez
Summary: The study demonstrated the benefits of using biofeedback as an adjunct therapy for women with bladder pain syndrome/interstitial cystitis, improving patients' quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study found significantly higher levels of urinary cytokines and chemokines in patients with IC/BPS, which were closely associated with bladder conditions and treatment outcomes.
Article
Urology & Nephrology
Jung Hyun Shin, Bosik Kang, Myung-Soo Choo
Summary: The study found that the features of HLs in IC patients were not associated with subjective symptoms, but inflammatory changes in HLs were a predictive factor for IC recurrence and associated with frequent urgency episodes and smaller bladder capacity.
JOURNAL OF UROLOGY
(2021)
Article
Immunology
Zhenming Zheng, Jiapeng Zhang, Caixia Zhang, Wenshuang Li, Kaiqun Ma, Hao Huang, Kuiqing Li, Yousheng Yao
Summary: This study demonstrates the important role of IL-6 in interstitial cystitis/bladder painful syndrome (IC/BPS), showing that it regulates the inflammatory response in bladder tissue. Evidence from coculture proves that macrophages are the source of IL-6 in IC/BPS.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Pharmacology & Pharmacy
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu
Summary: Inflammatory conditions of the urinary bladder are associated with urothelial damage and loss of function. The purinergic P2X7 receptor plays a role in such inflammatory conditions and may be a new therapeutic target for bladder inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
