期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 33, 期 6, 页码 443-453出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2014.921164
关键词
cytokines; macrophage; pathogen recognition; signaling cross-talk; toll-like receptors
类别
资金
- A*STAR Biomedical Research Council [BMRC: 10/1/21/19/658]
- National Medical Research Council [NMRC/CBRG/0055/2014]
Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different Toll-like receptor (TLR) ligands leads to quantitatively and qualitatively unique cytokine production, showing that TLR pathway crosstalk enables the innate immune system to orchestrate immediate local and global responses. It is likely that multiple pathways are involved in the regulation of cytokine synergy, including many that have yet to be discovered.
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