期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 34, 期 1, 页码 19-33出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2014.902452
关键词
aerobic glycolysis; CD4(+) T cells; glucose; immunity; metabolism; mTOR
类别
资金
- National Basic Research Program of China [2010CB945301, 2011CB710903]
- National Natural Science Foundation of China [C81130055, C81072396]
- Knowledge Innovation Program of Chinese Academy of Sciences [YSCX2-YW-238]
- CAS/SAFEA
Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naive T cells only require energy for survival and migration, and they mainly metabolize glucose to carbon dioxide through oxidative phosphorylation. However, activated T cells engage in robust cell proliferation, produce of a range of effector molecules and migrate through peripheral tissues, so they utilizes glycolysis to convert glucose to lactate (termed aerobic glycolysis) to meet the significantly increased metabolic demands. Importantly, the differentiation of T-cell subsets and memory T cells (Tm) was also significantly shaped by distinct cellular metabolic pathways including glucose, amino acids (AA), fatty acids (FA), and others. Understanding the regulatory metabolic networks on immunity may offer new insights into the immune-related disorders and open novel potential therapies to prevent and treat immune diseases.
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