期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 32, 期 3, 页码 324-336出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2012.762361
关键词
IL-10; immune inflammatory disease; lymphocytes; regulatory cell
类别
资金
- National Natural Science Foundation of China [81100887, 81273287, 31170864]
- Program for New Century Excellent Talents in the University of China
- Key Project of Natural Science Foundation of Tianjin Province [12JCZDJC24200]
- Key Project of Chinese Ministry of Education [212005]
IL-10 is an anti-inflammatory cytokine that plays a significant role in controlling inflammation and modulating adaptive immune responses that cause tissue damage. IL-10-producing lymphocytes contribute to the delicate balance between inflammation and immunoregulation, and are thus regarded as a kind of regulatory cells. Dysregulation of these cells is linked with susceptibility to numerous inflammatory diseases. In this review, we summarized what is known about the regulatory effects of IL-10 produced by lymphocytes, including T cells, B cells and natural killer cells, in inflammatory diseases. We hope to augment immune responses or prevent immunopathology through making some small changes in the levels of IL-10 produced by lymphocytes, or in the cellular location where it is produced.
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