Review
Genetics & Heredity
Reihaneh Alsadat Mahmoudian, Maharati Amirhosein, Parvaneh Mahmoudian, Fatemeh Fardi Golyan, Leila Mokhlessi, Mina Maftooh, Majid Khazaei, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon Ferns, Soodabeh Shahidsales, Amir Avan
Summary: Gastric cancer is a leading cause of mortality globally and presents challenges in diagnosis, prognosis, and therapy. Cancer-testis antigens (CTAs) have been identified as potential biomarkers and targets for cancer immunotherapy. Numerous studies have reported the dysregulation of CTAs in gastric cancer, and clinical trials have been conducted to evaluate their immunotherapeutic potential.
Article
Oncology
Diana Rose E. Ranoa, Preeti Sharma, Claire P. Schane, Amber N. Lewis, Edward Valdez, Venkata V. V. R. Marada, Marlies Hager, Will Montgomery, Steven P. Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M. Fan, Paul J. Hergenrother, Edward J. Roy, David M. Kranz
Summary: The use of CAR-T cell therapy against blood cancers has been successful, but its efficacy against solid tumors has been limited. By using a mouse ovarian cancer cell line, researchers found that CAR-T cell therapy can effectively inhibit the growth of solid tumors, with the most effective CAR having the highest affinity for the antigen.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Taiqing Liu, Yinqi Li, Xiaoyu Wang, Xiaodong Yang, Yunhai Fu, Yeteng Zheng, Hanlin Gong, Zhiyao He
Summary: Ovarian cancer is a common gynecologic malignancy with poor prognosis and high mortality. The tumor microenvironment in ovarian cancer is regulated by interferons (IFNs), which have bidirectional effects on cancer cell growth and immune cell activation. IFNs can assist in various types of therapy for ovarian cancer, except for some pathways that may cause drug resistance. IFNs have the potential to modulate the tumor microenvironment and provide new combination strategies for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Anliang Xia, Qi Yue, Mingming Zhu, Jianbo Xu, Siyuan Liu, Yue Wu, Zhangding Wang, Zhu Xu, Hongda An, Qiang Wang, Shouyu Wang, Beicheng Sun
Summary: This study discovered a novel cancer-testis-associated lncRNA, LINC01977, which is exclusively expressed in testes and highly expressed in hepatocellular carcinoma (HCC). High levels of LINC01977 were associated with poorer overall survival in HCC patients. Functional assays revealed that LINC01977 promotes HCC growth and metastasis by inhibiting Notch2 ubiquitination and degradation through its interaction with RBM39. The stability of LINC01977 is enhanced by the RNA binding protein IGF2BP2. These findings suggest that LINC01977 may serve as a potential biomarker and therapeutic target for HCC patients.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Ping Yang, Mei Meng, Quansheng Zhou
Summary: The study reveals that oncogenic CTAs are overexpressed in various cancers, promoting carcinogenesis, metastasis, and drug resistance. However, challenges in CTA-targeted cancer immunotherapy include deficient MHC-I antigen presentation, immunosuppressive cells in tumor tissues, and the tumor microenvironment reducing therapy efficacy. New strategies are proposed to overcome these barriers and develop potent immune therapeutics against cancer, as oncogenic CTAs show high tumor specificity and immunogenicity. Future breakthroughs in cancer therapy are expected with CTAs-targeted immunotherapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Jayanth S. Shankara Narayanan, Tomoko Hayashi, Suna Erdem, Sara McArdle, Herve Tiriac, Partha Ray, Minya Pu, Zbigniew Mikulski, Aaron Miller, Karen Messer, Dennis Carson, Stephen Schoenberger, Rebekah R. White
Summary: The combination of IRE and CD40Ab treatment can significantly improve the prognosis of pancreatic cancer, prolong patient survival, activate dendritic cells, identify and inhibit the progression of metastatic disease.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin
Summary: In this study, PRSS56, a testis-specific serine protease, was identified as a novel cancer/testis antigen. PRSS56 was frequently overexpressed in various cancers, especially in gastrointestinal cancer. The expression of PRSS56 was associated with DNA methylation levels, and its decreased methylation led to overexpression in GC and CRC. Furthermore, PRSS56 activated the oncogenic PI3K/AKT signaling pathway in GC and CRC.
CELL AND BIOSCIENCE
(2023)
Review
Oncology
Aarushi Audhut Caro, Sofie Deschoemaeker, Lize Allonsius, An Coosemans, Damya Laoui
Summary: This review provides an overview of current therapies for ovarian cancer, focusing on immunotherapies and the potential of dendritic cell vaccines. By highlighting different subsets of dendritic cells and their functions in ovarian cancer, we summarize the advancements and pitfalls of current dendritic cell vaccine strategies and discuss future perspectives for improving patient outcomes.
Review
Cell Biology
Peizhen Geng, Yuhua Chi, Yuan Yuan, Maoquan Yang, Xiaohua Zhao, Zhengchun Liu, Guangwei Liu, Yihui Liu, Liang Zhu, Shuai Wang
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that does not express certain receptors. Traditional therapies have limited efficacy against TNBC, and new treatment options are urgently needed. CAR-T therapy, a type of immunotherapy, has shown success in hematological cancers but has limitations in solid tumors like TNBC. This review explores the potential of CAR-T therapy in TNBC treatment, identifies therapeutic targets, and discusses strategies to overcome limitations and improve efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Yae Kye, Lokesh Nagineni, Shrikanth Gadad, Fabiola Ramirez, Hannah Riva, Lorena Fernandez, Michelle Samaniego, Nathan Holland, Rose Yeh, Kei Takigawa, Subramanian Dhandayuthapani, Jessica Chacon
Summary: This review article emphasizes the process and importance of identifying neoantigens for immunotherapy for cancer, highlighting the potential of personalized cancer therapy and the challenges related to neoantigen identification and clinical application.
Article
Immunology
Lina Lin, Weixia Nong, Bin Luo, Yingying Ge, Xia Zeng, Feng Li, Rong Fan, Qingmei Zhang, Xiaoxun Xie
Summary: This study found that ACRBP is upregulated in OC tissues and highly expressed in EOC, and is significantly correlated with FIGO stage and chemosensitivity. Serological analysis showed that anti-ACRBP antibody was detected in 28.5% of OC patients but not in healthy donors. The sensitivity and specificity for ACRBP antibody were 85.71% and 55.0%, respectively.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Oncology
Sofia Khazan-Kost, Gal Cafri, Dganit Melamed Kadosh, Navit Mooshayef, Sumit Chatterji, Dan Dominissini, Sigal Manor, Bracha Zisser, Limor Broday, Efrosiniia Talalai, Anat Shemer, Oranit Zadok, Efrat Ofek, Amir Onn, Arie Admon, Michael Peled
Summary: sHLA-peptide complexes in pleural effusions can serve as a source of biomarkers for malignant tumors and potential candidates for personalized immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Jianhang Zhao, Zhaoxu Xu, Yan Liu, Xiaobin Wang, Xinli Liu, Yanan Gao, Ying Jin
Summary: Ovarian cancer is a common and highly mortal tumor in the female reproductive system. It is often diagnosed at an advanced stage due to lack of apparent early symptoms and effective screening strategies. Immunotherapy using tumor-associated antigens shows promise in improving the treatment of ovarian cancer. Cancer-testis antigens (CTAs), including MAGE-A, NY-ESO-1, CT45, and Sp17, are highly expressed in ovarian cancer and are considered ideal targets for immunotherapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Ping Yang, Yingnan Qiao, Mei Meng, Quansheng Zhou
Summary: Lung cancer is the most common malignant tumor causing cancer-related deaths worldwide. CTAs, which are often overexpressed in lung cancer, play a significant role in the initiation, metastasis, and prognosis of the disease. Some CTAs have been identified as biomarkers and targets for diagnosis and treatment of lung cancer, including vaccines and CAR-T cells. However, there are still challenges to be overcome for clinical application.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Catherine M. Ade, Matthew J. Sporn, Sudipto Das, Zhiya Yu, Ken-ichi Hanada, Yue A. Qi, Tapan Maity, Xu Zhang, Udayan Guha, Thorkell Andresson, James C. Yang
Summary: This article introduces a method of using mass spectrometry to identify common tumor-specific neoepitopes derived from mutated oncogenes, and develop TCRs based on these data. The results of the study show that this method successfully identified precise neoepitopes derived from KRAS, EGFR, BRAF, and PIK3CA presented by HLA-A*03:01 and/or HLA-A*11:01 across multiple biological replicates.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Andrew W. Woodham, Joseph G. Skeate, Adriana M. Sanna, Julia R. Taylor, Diane M. Da Silva, Paula M. Cannon, W. Martin Kast
AIDS PATIENT CARE AND STDS
(2016)
Article
Immunology
Alcina F. Nicol, Laurie L. Brunette, Gerard J. Nuovo, Beatriz Grinsztejn, Ruth K. Friedman, Valdilea G. Veloso, Cynthia B. Cunha, Jose R. Coutinho, Cecilia Vianna de Andrade, Nathalia S. Oliveira, Andrew W. Woodham, Diane M. Da Silva, W. Martin Kast
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2016)
Article
Oncology
Leonardo Mirandola, Elisa Pedretti, Jose A. Figueroa, Raffaella Chiaramonte, Michela Colombo, Caroline Chapman, Fabio Grizzi, Federica Patrinicola, W. Martin Kast, Diane D. Nguyen, Rakhshanda Layeequr Rahman, Naval Daver, Peter Ruvolo, Sean M. Post, Robert S. Bresalier, Maurizio Chiriva-Internati
Article
Immunology
Maria de la Luz Garcia-Hernandez, Norma Ofelia Uribe-Uribe, Ricardo Espinosa-Gonzalez, W. Martin Kast, Shabaana A. Khader, Javier Rangel-Moreno
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Joseph G. Skeate, Diane M. Da Silva, Elena Chavez-Juan, Snjezana Anand, Richard Nuccitelli, W. Martin Kast
Article
Oncology
Andrew W. Woodham, Ross W. Cheloha, Jingjing Ling, Mohammad Rashidian, Stephen C. Kolifrath, Maia Mesyngier, Joao N. Duarte, Justin M. Bader, Joseph G. Skeate, Diane M. Da Silva, W. Martin Kast, Hidde L. Ploegh
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Oncology
Luana L. S. Rodrigues, Mariza G. Morgado, Vikrant V. Sahasrabuddhe, Vanessa S. De Paula, Nathalia S. Oliveira, Elena Chavez-Juan, Diane M. Da Silva, W. Martin Kast, Alcina F. Nicol, Jose H. Pilotto
GYNECOLOGIC ONCOLOGY
(2018)
Article
Multidisciplinary Sciences
Julia R. Taylor, Daniel J. Fernandez, Shantae M. Thornton, Joseph G. Skeate, Kim P. Luhen, Diane M. Da Silva, Ralf Langen, W. Martin Kast
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Laurie L. Brunette, Paulette Y. Mhawech-Fauceglia, Lingyun Ji, Joseph G. Skeate, Heike E. Brand, Kate Lawrenson, Saloni Walia, Maurizio Chiriva-Internati, Susan Groshen, Lynda D. Roman, W. Martin Kast, Diane M. Da Silva
Review
Microbiology
Julia R. Taylor, Joseph G. Skeate, W. Martin Kast
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Immunology
Diane M. Da Silva, Joseph G. Skeate, Elena Chavez-Juan, Kim P. Luhen, Jiun-Ming Wu, Chia-Mao Wu, W. Martin Kast, KinKai Hwang
Article
Cell Biology
Shantae M. Thornton, Varsha D. Samararatne, Joseph G. Skeate, Christopher Buser, Kim P. Luehen, Julia R. Taylor, Diane M. Da Silva, W. Martin Kast
Article
Oncology
Diane M. Da Silva, Emma A. Martinez, Lies Bogaert, W. Martin Kast
Summary: The selection of a therapeutic vaccine schedule can impact the magnitude, efficacy, and durability of immune responses. This study compared different prime-boost intervals in a human papillomavirus model and found that longer intervals can enhance long-term protective anti-tumor immunity.
Article
Virology
Luana Lorena Silva Rodrigues, Jose Henrique Pilotto, Katrini Guidolini Martinelli, Alcina F. Nicol, Vanessa Salete De Paula, Tarik Gheit, Nathalia Silva Carlos Oliveira, Carlos Silva-de-Jesus, Vikrant V. Sahasrabuddhe, Diane M. Da Silva, W. Martin Kast, Justin Hardick, Charlotte A. Gaydos, Mariza Goncalves Morgado
Summary: The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajos region, Amazon, Brazil. The overall prevalence of anal HPV infection was high, especially in HIV-infected women. The concordance analysis showed moderate to fair agreement between anal and genital HPV and non-HPV STIs.
Article
Virology
Jenny C. McCloskey, W. Martin Kast, James P. Flexman, Dugald McCallum, Martyn A. French, Michael Phillips
PAPILLOMAVIRUS RESEARCH
(2017)