期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 29, 期 3, 页码 315-348出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830181003792803
关键词
neonate; sepsis; neutrophil; innate immunity
类别
资金
- National Institute on Alcohol Abuse and Alcoholism [AA017494, AA07577, AA09803]
Sepsis has continuously been a leading cause of neonatal morbidity and mortality despite current advances in chemotherapy and patient intensive care facilities. Neonates are at high risk for developing bacterial infections due to quantitative and qualitative insufficiencies of innate immunity, particularly granulocyte lineage development and response to infection. Although antibiotics remain the mainstay of treatment, adjuvant therapies enhancing immune function have shown promise in treating sepsis in neonates. This article reviews current strategies for the clinical management of neonatal sepsis and analyzes mechanisms underlying insufficiencies of neutrophil defense in neonates with emphasis on new directions for adjuvant therapy development.
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