期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 29, 期 1, 页码 4-37出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/08830180903437212
关键词
Crohn's disease; ulcerative colitis; immunobiologic therapy; cytokines
类别
资金
- Government of Australia
Current advances in. understanding of the pathogenesis of inflammatory bowel disease have encouraged the development of many new therapies targeted at specific and non-specific mediators of the inflammatory bowel disease inflammatory pathway. Crohns disease and ulcerative colitis, two common inflammatory bowel diseases likely result from interaction of multiple genetic and environmental risk and protective factors, deregulation of mucosal immunity in gut and breakdown of delicate balance of proinflammatory and anti-inflammatory cytokines. Immuno-biologic agents targeted against TNF, leukocyte adhesion, Th1 polarization, T cell activation, nuclear factor-kappaB (NF-kappa B), and others are being assessed and will open exciting perspectives on development of therapies for inflammatory bowel disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据