☆ 4.3 Review

Could Autoimmunity Be Induced by Vaccination?

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2010)

期刊

INTERNATIONAL REVIEWS OF IMMUNOLOGY

卷 29, 期 3, 页码 247-269

出版社

TAYLOR & FRANCIS INC

DOI: 10.3109/08830181003746304

关键词

vaccinations; autoimmune diseases; systemic lupus erythematosus; rheumatoid arthritis; multiple sclerosis; insulin-dependent diabetes mellitus; vasculitides

类别

Immunology

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摘要

Autoimmune reactions to vaccinations may rarely be induced in predisposed individuals by molecular mimicry or bystander activation mechanisms. Autoimmune reactions reliably considered vaccine-associated, include Guillain-Barre syndrome after 1976 swine influenza vaccine, immune thrombocytopenic purpura after measles/mumps/rubella vaccine, and myopericarditis after smallpox vaccination, whereas the suspected association between hepatitis B vaccine and multiple sclerosis has not been further confirmed, even though it has been recently reconsidered, and the one between childhood immunization and type 1 diabetes seems by now to be definitively gone down. Larger epidemiological studies are needed to obtain more reliable data in most suggested associations.

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