期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 28, 期 3-4, 页码 139-154出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08830180902943058
关键词
microRNAs; noncoding RNAs; epithelium; immunoregulation
类别
资金
- National Institute of Health [R01 AI071321]
- Tobacco Settlement Foundation of Nebraska [692]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI071321] Funding Source: NIH RePORTER
MicroRNAs are required for development and maintenance of the epithelial barrier. It is hypothesized that microRNAs are involved in regulating epithelial antimicrobial defenses by targeting key epithelial effector molecules and/or influencing intracellular signaling pathways. Additionally, aberrant microRNA expression has been implicated in the pathogenesis of various diseases at the skin and mucosa. Increased understanding of the role of microRNAs in epithelial immunoregulation and identification of microRNAs of pathogenetic significance will enhance our understanding of epithelial immunobiology and immunopathology.
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