Article
Clinical Neurology
Guadalupe Garcia, Carlos J. Martinez-Magana, Norma Oviedo, Vinicio Granados-Soto, Janet Murbartian
Summary: Previous studies have shown that L5/L6 spinal nerve ligation enhances the expression of anoctamin-1 in injured and uninjured dorsal root ganglia (DRG), while L5 spinal nerve transection does not. The role of bestrophin-1 in these conditions is still unknown.
Article
Neurosciences
Kimberly Gomez, Alberto Vargas-Parada, Paz Duran, Alejandro Sandoval, Rodolfo Delgado-Lezama, Rajesh Khanna, Ricardo Felix
Summary: Voltage-gated Ca2+ channels play a crucial role in regulating cell processes and have been linked to neuropathic pain. Cdk5, a neuron-specific kinase, may phosphorylate Ca-v channels, altering their functional expression. Changes in Ca-v channels location and function in afferent fibers associated with Cdk5-mediated phosphorylation may contribute to nerve injury-induced allodynia.
Article
Pharmacology & Pharmacy
Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Morioka
Summary: The study demonstrates that increased HMGB1 around the injured sciatic nerve may induce nociceptive hypersensitivity through the activation of spinal microglia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Angel Zuniga-Romero, Quetzali Rivera-Plata, Jesus Arrieta, Francisco Javier Flores-Murrieta, Juan Rodriguez-Silverio, Juan Gerardo Reyes-Garcia, Juan Carlos Huerta-Cruz, Gustavo Ramirez-Martinez, Hector Isaac Rocha-Gonzalez
Summary: This study explored the participation of GPR55 and GPR119 in the processing of neuropathic pain and found that they could be useful targets to manage neuropathic pain disorders.
Article
Multidisciplinary Sciences
Friederike Auer, Eliana Franco Taveras, Uli Klein, Celine Kesenheimer, Dana Fleischhauer, Frank Moehrlen, Stephan Frings
Summary: The study confirmed the expression of Ano2 mRNA in Purkinje cells and examined the influence of ANO2-chloride channels on Purkinje cell excitability by comparing wildtype mice to mice lacking ANO2. The results showed that ANO2-mediated chloride currents attenuated simple spike activity in Purkinje cells during high current injections or close to the simple spike threshold. Additionally, there was a reduction in inhibitory currents from GABAergic interneurons upon depolarization, lasting for several seconds.
Article
Immunology
Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian Xu
Summary: The study reveals that the upregulation of KDM6B induced by neuropathic pain demethylates H3K27me3, facilitating the binding of STAT3 with the IL-6 promoter, consequently leading to an increase in IL-6 expression in the DRG and dorsal horn which contributes to the development and maintenance of neuropathic pain. Targeting KDM6B may be a promising therapeutic strategy for the treatment of chronic pain.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Donald Iain MacDonald, Ana P. Luiz, Federico Iseppon, Queensta Millet, Edward C. Emery, John N. Wood
Summary: Neuropathic pain leads to innocuous cooling being perceived as excruciating pain, yet the cell and molecular basis of this cold allodynia remains poorly understood. Research has found that in neuropathic pain states, normally silent large diameter cold-sensing neurons become sensitive to cooling, with many of them responding to noxious mechanical stimuli.
Article
Biochemistry & Molecular Biology
Siqi Wei, Shuyang Chang, Yue Dong, Linping Xu, Xiaocui Yuan, Hong Jia, Jun Zhang, Lingli Liang
Summary: The study indicates that electro-acupuncture can alleviate neuropathic pain by inhibiting the AXL signaling pathway, and the combination of AXL inhibitor and electro-acupuncture may have a synergistic effect, providing a new strategy for clinical treatment of neuropathic pain.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Shiwu Guo, Zhiwen Song, Junsheng He, Gang Yin, Jianguo Zhu, Haifeng Liu, Lei Yang, Xubiao Ji, Xu Xu, Zhiyuan Liu, Jinbo Liu
Summary: This study investigates the role of aquaporin-4 (AQP4) and Akt pathways in the pathogenesis of neuropathic pain (NP). The results indicate that AQP4 is significantly upregulated in the spinal dorsal horn (SDH) and primarily expressed in astrocytes. Inhibition of AQP4 attenuates glial activation and anti-neuroinflammatory mechanisms, reducing the development and maintenance of NP. Similarly, inhibition of Akt suppresses AQP4 upregulation and astrocyte activation, alleviating NP in the early and late phases after spinal nerve ligation (SNL).
Article
Cell Biology
Lingyong Li, Shao-Rui Chen, Meng-Hua Zhou, Li Wang, De-Pei Li, Hong Chen, Garam Lee, Vasanthi Jayaraman, Hui-Lin Pan
Summary: The study reveals that nerve injury potentiates postsynaptic CP-AMPARs in the spinal dorsal horn via alpha 2 delta-1, which interacts with GluA1 and GluA2 to regulate the subunit composition and synaptic expression of AMPARs. Inhibition of alpha 2 delta-1 restores the intracellular assembly and synaptic dominance of heteromeric GluA1/GluA2 receptors, highlighting alpha 2 delta-1 as a key regulator of AMPAR function.
Article
Surgery
Chao Xu, TianYu Liu, YunPeng Zhang, Yi Feng
Summary: In this study, bioinformatics analysis was conducted to identify mechanisms for more effective treatments of neuropathic pain. Seven hub genes and potential targeting miRNA related to the pathogenesis of neuropathic pain were identified, expanding understanding of the mechanism and facilitating treatment development.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Kathleen Elverson, Sally Freeman, Forbes Manson, Jim Warwicker
Summary: Many transmembrane proteins are modulated by intracellular or extracellular pH. Mutagenesis guided by amino-acid conservation and structure can be used to investigate pH dependence, but prediction of pKas can streamline this process. The hypothesis of modulation of calcium/proton coupling and pH-dependent activity through the extent of structural relaxation applies to various proteins, including bestrophin 1, TMEM16A, calmodulin, and calbindin D9k. Predicting altered pH dependence for mutations in ion channel disorders can support experimental studies and clinical intervention.
Article
Anesthesiology
Chi-Yuan Chiu, Meei-Ling Tsaur
Summary: Kv4.1 channels are involved in pain regulation, and their expression levels change after peripheral nerve injury in secondary nociceptive neurons and the spinal cord.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Pharmacology & Pharmacy
Gabriela Becker, Maria Fernanda Pessano Fialho, Indiara Brusco, Sara Marchesan Oliveira
Summary: Cisplatin is a commonly used chemotherapy drug for solid tumors, but its effectiveness is limited by neurotoxic side effects such as peripheral neuropathy. This study investigates the role of kinin B-1 and B-2 receptors in cisplatin-induced peripheral neuropathy in mice. The results suggest that targeting these receptors may be a potential strategy for treating the painful symptoms caused by cisplatin treatment.
Article
Chemistry, Medicinal
Yu-Peng Zhou, Yang Sun, Kazue Takahashi, Vasily Belov, Nick Andrews, Clifford J. Woolf, Pedro Brugarolas
Summary: Neuropathic pain affects a significant portion of the adult population, and accurately monitoring biological changes is crucial for understanding its mechanisms and developing treatments. In this study, researchers developed two fluorinated derivatives of gabapentin and demonstrated their ability to bind to the alpha 2 delta-1 receptor, which is involved in neuropathic pain. Although these changes could not be visualized using PET, the study confirms the potential of alpha 2 delta-1 as a target for imaging neuropathic pain.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Adriana Morales-Martinez, Absalom Zamorano-Carrillo, Sergio Montes, Mohammed El-Hafidi, Alicia Sanchez-Mendoza, Elizabeth Soria-Castro, Juan Carlos Martinez-Lazcano, Pablo Eliasib Martinez-Gopar, Camilo Rios, Francisca Perez-Severiano
Summary: This study revealed an increase in EPA content in striatal synaptosomes after a diet rich in fatty acids, and synaptosomes enriched with fatty acids showed significant reduction in oxidative damage, indicating that EFAs, particularly EPA, improve membrane fluidity and confer antioxidant effects.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Urzula Franco-Enzastiga, Guadalupe Garcia, Janet Murbartian, Rodrigo Gonzalez-Barrios, Ana B. Salinas-Abarca, Beatriz Sanchez-Hernandez, Diana Tavares-Ferreira, Luis A. Herrera, Paulino Barragan-Iglesias, Rodolfo Delgado-Lezama, Theodore J. Price, Vinicio Granados-Soto
Summary: This study examined the sexual dimorphism in neuropathic rodents regarding alpha(5)-GABA(A) receptors, revealing an increase in receptor expression in DRG of nerve-injured females and a decrease in males. Ovariectomy abolished the antiallodynic effect of L-655,708 in females, which was restored by estradiol supplementation. In males, DNA methylation inhibition increased the receptor expression and enabled the antinociceptive effect, suggesting a potential treatment target for chronic pain in females.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Diana Tavares-Ferreira, Pradipta R. Ray, Ishwarya Sankaranarayanan, Galo L. Mejia, Andi Wangzhou, Stephanie Shiers, Ruta Uttarkar, Salim Megat, Paulino Barragan-Iglesias, Gregory Dussor, Armen N. Akopian, Theodore J. Price
Summary: The study identified sex differences in the transcriptome and translatome of mouse DRG, particularly focusing on genes related to prostaglandins and nociception. These findings provide insights into the mechanistic basis of sex differences in pain processing.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Anesthesiology
Paulino Barragan-Iglesias, Nikesh Kunder, Andi Wanghzou, Bryan Black, Pradipta R. Ray, Tzu-Fang Lou, June Bryan de la Pena, Rahul Atmaramani, Tarjani Shukla, Joseph J. Pancrazio, Theodore J. Price, Zachary T. Campbell
Summary: The study reveals widespread translation in regions annotated as noncoding in nociceptors, as well as in regulatory regions of mRNAs. A specific uORF-encoded peptide promotes pain sensitization through GPCR signaling.
Article
Behavioral Sciences
Quetzalli D. Angeles-Lopez, Lucia Garcia-Lara, Nicolas Aguirre-Pineda, Rolando Castaneda-Arellano, Guillermo Elizondo-Azuela, Francisca Perez-Severiano, Jose Segovia
Summary: The lack of AhR reduces neurological damage and behavioral deterioration in a mouse model of Huntington's disease, suggesting that pharmacological modulation of AhR could be a potential therapeutic target for HD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
June Bryan de la Pena, Nikesh Kunder, Tzu-Fang Lou, Rebecca Chase, Alexander Stanowick, Paulino Barragan-Iglesias, Joseph J. Pancrazio, Zachary T. Campbell
Summary: The study revealed that inflammatory mediators promote the translation of c-Fos, with the mTOR effector S6K1 being crucial for c-Fos biosynthesis. Inhibition of S6K1 or c-Fos can alleviate mechanical and thermal hypersensitivity caused by inflammatory cues and reduce induced nociceptor activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
June Bryan de la Pena, Paulino Barragan-Iglesias, Tzu-Fang Lou, Nikesh Kunder, Sarah Loerch, Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Dominique N. James, Salim Megat, Jamie K. Moy, Andi Wanghzou, Pradipta R. Ray, Kenneth Hoyt, Oswald Steward, Theodore J. Price, Jason Shepherd, Zachary T. Campbell
Summary: Studies have shown that activity-dependent protein Arc plays an important role in translational regulation in sensory neurons, potentially regulating neurogenic inflammation in the skin through intercellular signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Abraham Hernandez-Coro, Beatriz Eugenia Sanchez-Hernandez, Sergio Montes, Juan Carlos Martinez-Lazcano, Edith Gonzalez-Guevara, Francisca Perez-Severiano
Summary: Lead is a common pollutant that interacts with cells and tissues, causing behavioral and physiological alterations, as well as biochemical and epigenetic changes at a neurotransmitter level, leading to negative impacts on behavior and learning.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Felipe Patricio, Daniel Juarez-Torres, Aleidy Patricio-Martinez, Liliana Mendieta, Francisca Perez-Severiano, Sergio Montes, Jose Aguilera, Ilhuicamina Daniel Limon
Summary: The recombinant carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) has neuroprotective and neurorestorative effects on the dopaminergic system of animal models of Parkinson's disease. In this study, the Hc-TeTx fragment was found to decrease oxidative stress, nitrosative stress, and neurodegeneration markers induced by the acute toxicity of 1-methyl-4-phenylpyridinium. The administration of Hc-TeTx also increased the activity of superoxide dismutase and reduced the levels of 3-nitrotyrosine and glial fibrillary acidic protein.
NEUROSCIENCE RESEARCH
(2022)
Review
Neurosciences
Priscila Vazquez-Leon, Abraham Miranda-Paez, Jesus Chavez-Reyes, Gonzalo Allende, Paulino Barragan-Iglesias, Bruno A. Marichal-Cancino
Summary: The periaqueductal gray (PAG) is a complex mesencephalic structure involved in integrating and executing self-protective behaviors against threats, and is associated with drug addiction.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Pablo Eliasib Martinez-Gopar, Marian Jesabel Perez-Rodriguez, Gabriela Rodriguez-Manzo, Rene Garduno-Gutierrez, Luis Tristan-Lopez, Quetzalli Denisse Angeles-Lopez, Claudia Gonzalez-Espinosa, Francisca Perez-Severiano
Summary: The study shows that mast cells (MCs) and histamine (HA) play a role in the neuronal and oxidative damage observed in mice subjected to the QUIN-induced model of Huntington's disease.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Adriana Morales-Martinez, Paola A. Martinez-Gomez, Daniel Martinez-Fong, Marcos M. Villegas-Rojas, Francisca Perez-Severiano, Miguel A. Del Toro-Colin, Karen M. Delgado-Minjares, Victor Manuel Blanco-Alvarez, Bertha Alicia Leon-Chavez, Omar Emiliano Aparicio-Trejo, Mauricio T. Baez-Cortes, Maria-del-Carmen Cardenas-Aguayo, Jose Luna-Munoz, Mar Pacheco-Herrero, Quetzalli D. Angeles-Lopez, Irma A. Martinez-Davila, Citlaltepetl Salinas-Lara, Jose Pablo Romero-Lopez, Carlos Sanchez-Garibay, Adolfo R. Mendez-Cruz, Luis O. Soto-Rojas
Summary: This study developed a rat model of alpha-synucleinopathy and investigated the relationship between oxidative stress, mitochondrial dysfunction, and neurodegeneration in different brain regions. The findings suggest the involvement of peroxisome proliferator-activated receptors in the pathogenesis and potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Pablo E. Martinez-Gopar, Marian J. Perez-Rodriguez, Quetzalli D. Angeles-Lopez, Luis Tristan-Lopez, Claudia Gonzalez-Espinosa, Francisca Perez-Severiano
Summary: Toll-like receptors (TLRs) play a key role in innate immunity responses and their overactivation can lead to neuroinflammation and neural damage in neurodegenerative diseases such as Huntington's disease (HD). Research has shown that TLR4 expression in the brain and neurons can improve symptoms of neurodegeneration. Furthermore, low expression of TLR4 can delay the onset of phenotypic manifestations in HD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell & Tissue Engineering
W. Li, S. Trbojevic, J. B. Pineda-Farias, X. Liu, M. S. Gold, A. J. Almarza
Summary: The study compared different dental splint models and materials for inducing abnormal loading on the mandibular condylar processes in rats. The results showed that the resin molar splint caused the most extensive remodeling of the condylar process. Future studies will assess the impact of duration, age, and sex on the remodeling process.
EUROPEAN CELLS & MATERIALS
(2023)
Meeting Abstract
Clinical Neurology
Marian Jesabel Perez-Rodriguez, Francisca Perez-Severiano, Guadalupe Reyes-Cruz, Claudia Gonzalez Espinosa
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)