Article
Endocrinology & Metabolism
Katia Perri, Letizia De Mori, Domenico Tortora, Maria Grazia Calevo, Anna E. M. Allegri, Flavia Napoli, Giuseppa Patti, Daniela Fava, Marco Crocco, Maurizio Schiavone, Emilio Casalini, Mariasavina Severino, Andrea Rossi, Natascia Di Iorgi, Roberto Gastaldi, Mohamad Maghnie
Summary: Children with permanent congenital hypothyroidism have lower cognitive scores compared to those with transient CH and healthy controls. Offspring born to mothers with Hashimoto's thyroiditis or with a family history of thyroid disorders also show lower IQ values and cognitive functions. Significant correlations between white matter microstructural abnormalities, clinical measures, and cognitive impairment were found in children with permanent CH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Clinical Neurology
S. Richard-Devantoy, I. Badillo, J. A. Bertrand, M. Dicker, A. Banikyan, G. Turecki, M. C. Geoffroy, M. Orri
Summary: This systematic review and meta-analysis examined the association between childhood cognitive skills and adult suicidal behavior. The results suggest that individuals with lower cognitive skills in childhood have an increased risk of suicidal behavior in adulthood, especially males. Although the association is small, interventions that improve cognitive skills may have significant effects on suicide prevention at the population level if the association is causal.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Hirosuke Inoue, Masafumi Sanefuji, Yuri Sonoda, Masanobu Ogawa, Norio Hamada, Masayuki Shimono, Reiko Suga, Shoji F. Nakayama, Yu Taniguchi, Koichi Kusuhara, Shouichi Ohga, Michihiro Kamijima
Summary: This study aimed to investigate the association between prenatal blood lead levels and neurodevelopmental delay during early childhood. The analysis of a large dataset showed no convincing evidence for an inverse association between levels of prenatal blood lead and neurodevelopment in early childhood. Further longitudinal measurements of both prenatal and postnatal lead levels are needed to better understand the relationship between lead exposure and neurocognitive development.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Qiaoyang Zhang, Shan Huang, Yin Cao, Guanzhong Dong, Yun Chen, Xuanyan Zhu, Wenwei Yun, Min Zhang
Summary: This study found that plasma remnant cholesterol is associated with MCI and is correlated with impaired cognition in MCI patients. The study also showed a positive association between plasma remnant cholesterol level and MCI risk. However, further large longitudinal studies are needed to confirm the results and clarify the cause-and-effect relationship.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Green & Sustainable Science & Technology
Lan Lin, Yue Jin, Min Xiong, Shuicai Wu, Shen Sun
Summary: Sustainable cognitive health is affected by cognitive reserve, which delays or reduces cognitive decline by enhancing cognitive function. This study explores whether cognitive reserve moderates the relationship between white matter integrity and cognitive function in older adults. The findings reveal that early fluid intelligence has a significant independent and moderating impact on cognitive performance, making it a suitable individual proxy for cognitive reserve. Additionally, a composite proxy of early fluid intelligence and physical activity shows promise in promoting sustainable cognitive health.
Article
Immunology
G. David Batty, Ian J. Deary, Chloe Fawns-Ritchie, Catharine R. Gale, Drew Altschul
Summary: A study found that individuals with lower cognitive function are more likely to be hesitant about the COVID-19 vaccine, even after considering factors such as age, sex, and ethnicity. This suggests that erroneous social media reports may complicate personal decision-making.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Public, Environmental & Occupational Health
Xingqi Cao, Chen Chen, Liu He, Zhoutao Zheng, Jingyun Zhang, Emiel O. Hoogendijk, Xiaoting Liu, Shujuan Li, Xiaofeng Wang, Yimin Zhu, Zuyun Liu
Summary: This study developed and validated a new functional score based on self-reported cognitive and physical function in the older Chinese population. The score was found to be associated with all-cause mortality risk and showed additional predictive utility beyond age and sex. It was also demonstrated to be a simple and practical tool for assessing functional deterioration.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Yue Jin, Lan Lin, Min Xiong, Shen Sun, Shui-cai Wu
Summary: The study examines the importance of cognitive reserve (CR) for brain integrity and cognitive outcomes using UK Biobank data. The findings suggest that the effects of CR on brain integrity and cognition vary depending on the proxy used, brain integrity indicators, cognitive domain, and age group.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Kimberly D. van der Willik, Silvan Licher, Elisabeth J. Vinke, Maria J. Knol, Sirwan K. L. Darweesh, Jos N. van der Geest, Sanne B. Schagen, M. Kamran Ikram, Annemarie Luik, M. Arfan Ikram
Summary: The study revealed that cognitive and motor function decline with age among community-dwelling individuals aged 45-90, with steeper declines seen after ages 65-70. Lower educated participants had lower cognitive function at baseline and experienced a faster decline compared to those with higher education, although this educational effect was not observed in motor function.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Vivian Castillo de Lima, Luz Albany Arcila Castano, Ricardo Aurelio Carvalho Sampaio, Priscila Yukari Sewo Sampaio, Camila Vieira Ligo Teixeira, Marco Carlos Uchida
Summary: Agility training is essential for improving neuromuscular performance and balance in older adults. This study examined the physical and cognitive effects of an agility ladder training program on healthy older adults. The results showed that only the group that received cognitive training alongside agility training showed improvements in cognitive function, while the group that only performed agility training saw improvements in physical performance.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Carlos Marquez, Barbara Angel, Lydia Lera, Rebecca Bendayan, Hugo Sanchez, Cecilia Albala
Summary: This longitudinal study explored the association between vitamin D levels and cognitive performance in older Chilean people and found that low vitamin D levels were a risk factor for mild cognitive impairment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Pedro G. S. Braga, Fatima R. Freitas, Andre L. L. Bachi, Gislene R. Amirato, Roberta V. Baroni, Maria Janieire N. N. Alves, Rodolfo P. Vieira, Mauro W. Vaisberg, Marlene N. Aldin, Roberto Kalil Filho, Antonio M. Figueiredo Neto, Nagila R. T. Damasceno, Thauany M. Tavoni, Raul C. Maranhao, Zhen Chen
Summary: This study investigated the effects of regular physical activity on two important functions of HDL, namely cholesterol reception and antioxidant capacity. The results showed that active individuals had higher HDL-C levels, better cholesterol transfer, and more HDL subfractions compared to inactive individuals. Age did not have a significant effect on these functions.
Article
Geriatrics & Gerontology
Sadaf Arefi Milani, Tyler R. Bell, Michael Crowe, Caitlin N. Pope, Brian Downer
Summary: This study aimed to evaluate the bidirectional association between pain interference and cognitive performance. The findings suggest that increased pain interference is associated with greater cognitive decline, while better baseline cognitive performance is related to lower pain interference at follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Hui Liu, Zhenmei Zhang, Yan Zhang
Summary: The study provides insight into the association between trajectories of marital quality and cognitive functioning among older adults, with a focus on gender differences. Initial positive marital quality correlated with better initial cognition in older adults, while negative marital quality correlated with worse cognition. An increase in positive marital quality was associated with a slower rate of cognitive decline in men, emphasizing the importance of maintaining a good marital relationship for cognitive health in later life.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Geriatrics & Gerontology
Hyunkyu Kim, Seung Hoon Kim, Wonjeong Jeong, Sung-In Jang, Eun-Cheol Park, Youseok Kim
Summary: This study identified a relationship between changing handgrip strength and cognitive function, with decreasing handgrip strength associated with decline in cognitive function over time.
Article
Psychology, Clinical
Matthew H. Iveson, Adele Taylor, Sarah E. Harris, Ian J. Deary, Andrew M. McIntosh
Summary: The study found that APOE e4 allele status did not significantly predict depressive symptom score trajectories or depression risk after adjusting for other factors. However, greater functional limitations at baseline significantly predicted poorer symptom score trajectories and increased depression risk.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
David M. Howard, Oliver Pain, Ryan Arathimos, Miruna C. Barbu, Carmen Amador, Rosie M. Walker, Bradley Jermy, Mark J. Adams, Ian J. Deary, David Porteous, Archie Campbell, Patrick F. Sullivan, Kathryn L. Evans, Louise Arseneault, Naomi R. Wray, Michael Meaney, Andrew M. McIntosh, Cathryn M. Lewis
Summary: Early life environments influence DNA methylation, but no overlap was found between these environments and mental health conditions in this study.
HUMAN MOLECULAR GENETICS
(2022)
Article
Medicine, General & Internal
G. David Batty, Ian J. Deary, Drew Altschul
Summary: This study aims to explore the predictors of COVID-19 vaccine hesitancy and found that individuals with poor physical health are more likely to accept vaccination, while mental health is unrelated.
ANNALS OF MEDICINE
(2022)
Article
Psychiatry
Mathew A. Harris, Simon R. Cox, Laura de Nooij, Miruna C. Barbu, Mark J. Adams, Xueyi Shen, Ian J. Deary, Stephen M. Lawrie, Andrew M. McIntosh, Heather C. Whalley
Summary: This study examined the relationship between depression and brain structure using neuroimaging data and lifetime depression information. The results showed that lifetime depression was consistently associated with reduced white matter integrity, while self-reported depression was negatively correlated with cortical thickness. The effects of different depression phenotypes on brain structure were small overall but significant for cortical thickness.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Gergo Baranyi, Miles Welstead, Janie Corley, Ian J. Deary, Graciela Muniz-Terrera, Paul Redmond, Niamh Shortt, Adele M. Taylor, Catharine Ward Thompson, Simon R. Cox, Jamie Pearce
Summary: This study investigates the impact of neighborhood social deprivation (NSD) on frailty among older adults, and finds that greater accumulated NSD is associated with higher baseline frailty in males, while higher NSD in the mid- to late adulthood period is associated with widening frailty trajectories in females. This is the first investigation of the life-course impact of NSD on frailty in a cohort of older adults.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Matthew H. Iveson, Simon R. Cox, Ian J. Deary
Summary: This study examines the association between intergenerational social mobility and later-life health using diagonal reference models. The results show no significant association between social mobility and later-life health, but individuals from higher occupational social classes have lower mortality rates.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jari Lahti, Samuli Tuominen, Qiong Yang, Giulio Pergola, Shahzad Ahmad, Najaf Amin, Nicola J. Armstrong, Alexa Beiser, Katharina Bey, Joshua C. Bis, Eric Boerwinkle, Jan Bressler, Archie Campbell, Harry Campbell, Qiang Chen, Janie Corley, Simon R. Cox, Gail Davies, Philip L. De Jager, Eske M. Derks, Jessica D. Faul, Annette L. Fitzpatrick, Alison E. Fohner, Ian Ford, Myriam Fornage, Zachary Gerring, Hans J. Grabe, Francine Grodstein, Vilmundur Gudnason, Eleanor Simonsick, Elizabeth G. Holliday, Peter K. Joshi, Eero Kajantie, Jaakko Kaprio, Pauliina Karell, Luca Kleineidam, Maria J. Knol, Nicole A. Kochan, John B. Kwok, Markus Leber, Max Lam, Teresa Lee, Shuo Li, Anu Loukola, Tobias Luck, Riccardo E. Marioni, Karen A. Mather, Sarah Medland, Saira S. Mirza, Mike A. Nalls, Kwangsik Nho, Adrienne O'Donnell, Christopher Oldmeadow, Jodie Painter, Alison Pattie, Simone Reppermund, Shannon L. Risacher, Richard J. Rose, Vijay Sadashivaiah, Markus Scholz, Claudia L. Satizabal, Peter W. Schofield, Katharina E. Schraut, Rodney J. Scott, Jeannette Simino, Albert V. Smith, Jennifer A. Smith, David J. Stott, Ida Surakka, Alexander Teumer, Anbupalam Thalamuthu, Stella Trompet, Stephen T. Turner, Sven J. van der Lee, Arno Villringer, Uwe Voelker, Robert S. Wilson, Katharina Wittfeld, Eero Vuoksimaa, Rui Xia, Kristine Yaffe, Lei Yu, Habil Zare, Wei Zhao, David Ames, John Attia, David A. Bennett, Henry Brodaty, Daniel I. Chasman, Aaron L. Goldman, Caroline Hayward, M. Arfan Ikram, J. Wouter Jukema, Sharon L. R. Kardia, Todd Lencz, Markus Loeffler, Venkata S. Mattay, Aarno Palotie, Bruce M. Psaty, Alfredo Ramirez, Paul M. Ridker, Steffi G. Riedel-Heller, Perminder S. Sachdev, Andrew J. Saykin, Martin Scherer, Peter R. Schofield, Stephen Sidney, John M. Starr, Julian Trollor, William Ulrich, Michael Wagner, David R. Weir, James F. Wilson, Margaret J. Wright, Daniel R. Weinberger, Stephanie Debette, Johan G. Eriksson, Thomas H. Mosley, Lenore J. Launer, Cornelia M. van Duijn, Ian J. Deary, Sudha Seshadri, Katri Raikkonen
Summary: This study examines the associations between genetic variants and verbal short-term memory and learning in adults, revealing several genomic loci that are implicated in these processes. Functional and bioinformatic analyses support these findings, while genetic correlations with neurocognitive and health outcomes further highlight the significance of these memory traits.
MOLECULAR PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Una Clancy, Ratko Radakovic, Fergus Doubal, Maria del C. Valdes Hernandez, Susana Munoz Maniega, Adele M. Taylor, Janie Corley, Francesca M. Chappell, Tom C. Russ, Simon R. Cox, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Summary: This study aimed to identify the association between apathy, depression, anxiety, and subjective memory complaints with longitudinal white matter hyperintensity (WMH) progression. The study found that apathy symptoms were associated with an increase in WMH, while depression, anxiety, and subjective memory complaints were not.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Neurosciences
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Summary: Neurogranin (Ng), a post-synaptic protein, has been investigated as a biomarker for Alzheimer's disease (AD) and aging in cerebrospinal fluid (CSF). Our study examined Ng abundance in post-mortem human brain tissue in AD, healthy aging (HA), and mid-life (ML) cohorts. Ng levels were quantified using immunohistochemistry in brain regions associated with cognitive change. The results showed significantly reduced Ng levels in AD compared to HA and ML cases, indicating loss of neurogranin in the brain. Our findings support the use of CSF Ng as a biomarker for AD and cognitive decline in healthy aging.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Anna E. Furtjes, Ryan Arathimos, Jonathan R. I. Coleman, James H. Cole, Simon R. Cox, Ian J. Deary, Javier de la Fuente, James W. Madole, Elliot M. Tucker-Drob, Stuart J. Ritchie
Summary: Understanding the neurodegenerative mechanisms of cognitive decline can help detect health issues in late life. This study explores the genetic links between brain morphometry, aging, and cognitive ability using Genomic Principal Components Analysis. The analysis reveals moderate shared genetic etiology between brain-wide morphometry and cognitive aging, suggesting a potential genetic basis for age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemistry & Molecular Biology
V. Kartik Chundru, Riccardo E. Marioni, James G. D. Prendergast, Tian Lin, Allan J. Beveridge, Nicholas G. Martin, Grant W. Montgomery, David A. Hume, Ian J. Deary, Peter M. Visscher, Naomi R. Wray, Allan F. McRae
Summary: Testing the effect of rare variants on phenotypic variation is challenging due to the need for large cohorts. This study investigates the effect of rare genetic variants on DNA methylation (DNAm) and demonstrates their role in phenotypic variation. The study also shows that extreme levels of DNAm have functional consequences on gene expression.
HUMAN MOLECULAR GENETICS
(2023)
Article
Geriatrics & Gerontology
Ashleigh C. Duthie, Jean Hannah, G. David Batty, Ian J. Deary, John M. Starr, Daniel J. Smith, Tom C. Russ
Summary: This study investigated the association between lithium levels in drinking water and the rate of dementia using data from the Scottish Mental Survey 1932. The results showed that lithium levels in drinking water are very low in Scotland, and extremely low levels of lithium are not associated with an increased risk of dementia. However, there was a slight trend towards increased risk in females at lithium levels below 2.1 mu g/L.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Correction
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Diez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Bohm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Article
Geriatrics & Gerontology
Michelle Luciano, J. Corley, M. C. Valdes Hernandez, L. C. A. Craig, G. McNeill, M. E. Bastin, I. J. Deary, S. R. Cox, J. M. Wardlaw
Summary: This study examined the association between adherence to the Mediterranean diet at age 70 and longitudinal trajectories of total brain volume over a six-year period from age 73 to 79. The findings showed no significant association between adherence to the Mediterranean diet and total brain volume change during this period.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Biotechnology & Applied Microbiology
Daniel L. McCartney, Robert F. Hillary, Eleanor L. S. Conole, Daniel Trejo Banos, Danni A. Gadd, Rosie M. Walker, Cliff Nangle, Robin Flaig, Archie Campbell, Alison D. Murray, Susana Munoz Maniega, Maria Del C. Valdes-Hernandez, Mathew A. Harris, Mark E. Bastin, Joanna M. Wardlaw, Sarah E. Harris, David J. Porteous, Elliot M. Tucker-Drob, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary, Simon R. Cox, Matthew R. Robinson, Riccardo E. Marioni
Summary: By analyzing blood-based DNA methylation, individual differences in general cognitive function can be explained, which is important for tracking the development of neurodegenerative diseases. Assessing cognitive function using DNAm data may be valuable in environments where reliable or accessible cognitive testing is lacking.