Article
Neurosciences
Lin Huang, Yatian Li, Jingnan Wu, Nan Chen, Huanhuan Xia, Qihao Guo
Summary: A voice recognition-based cognitive assessment tool has been developed and demonstrated to have good diagnostic accuracy in detecting MCI and AD dementia. The tool performs well in measuring visual memory, language, and executive function, and has the potential to facilitate large-scale community screening.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychiatry
Ronat Lucas, Monchi Oury, Hanganu Alexandru
Summary: The potential impact of sex on cognitive performance in normal aging and Alzheimer's disease patients has been discussed. This study found that cognitive performance differs according to sex and clinical stage. Depression and apathy have different effects on cognitive performance in women and men.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Nursing
Sangwoo Ahn, Michelle A. Mathiason, Fang Yu
Summary: Depressive symptoms were predictive of lower episodic memory and executive function. Nurses should pay attention to depressive symptoms in older adults with SCD, as managing depressive symptoms may help prevent cognitive decline more typical of early Alzheimer's dementia.
JOURNAL OF NURSING SCHOLARSHIP
(2021)
Article
Geriatrics & Gerontology
Geoffroy Gagliardi, Patrizia Vannini
Summary: This study investigates the mechanisms of awareness loss in Alzheimer's Disease, and finds that dysfunction in episodic memory is primarily responsible for the effect of amyloid on awareness.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Riccardo Sacripante, Nicola Girtler, Elisa Doglione, Flavio Nobili, Sergio Della Sala
Summary: This study aimed to investigate if the forgetting rates of individuals with mild cognitive impairment due to Alzheimer's disease (MCI-AD) differ from age-matched healthy controls (HC) using a prose paradigm. The results showed that compared to HC, MCI-AD individuals exhibited poorer encoding at immediate recall and steeper forgetting up to 1 hour in prose memory. However, there were no differences in forgetting rates between groups from 1 hour to 24 hours.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Neurosciences
Anne R. Carlew, Alyssa Kaser, Jeff Schaffert, William Goette, Laura Lacritz, Heidi Rossetti
Summary: Through a review of the literature, it was found that the neuropsychological actuarial method has some utility in diagnosing mild cognitive impairment (MCI) in large-scale homogenous databases, but its accuracy relative to consensus diagnostic methods is unclear, and emerging evidence suggests that the neuropsychological actuarial method may be more prone to diagnostic errors in more demographically diverse populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Melanie Fortier, Christian-Alexandre Castellano, Valerie St-Pierre, Etienne Myette-Cote, Francis Langlois, Maggie Roy, Marie-Christine Morin, Christian Bocti, Tamas Fulop, Jean-Philippe Godin, Carla Delannoy, Bernard Cuenoud, Stephen C. Cunnane
Summary: Supplementation with ketogenic medium chain triglyceride (kMCT) drink significantly improved cognitive outcomes in mild cognitive impairment (MCI), possibly by increasing blood ketone levels. These data support further evaluation of MCI progression to Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2021)
Article
Medicine, General & Internal
Glykeria Tsentidou, Despina Moraitou, Magdalini Tsolaki, Elvira Masoura, Vasileios Papaliagkas
Summary: With the aging of the population, it is important to keep individuals cognitively healthy. Vascular aging has a negative impact on cognitive skills, increasing the risk of dementia. This study focuses on two groups - adults with vascular risk factors and those with both vascular risk factors and mild cognitive impairment. The findings show that global cognitive status and short-term memory decline in individuals with vascular risk factors, while Theory of Mind abilities can better capture the impairment in those with both risk factors and mild cognitive impairment.
Article
Medicine, General & Internal
Salvatore Mazzeo, Valentina Bessi, Silvia Bagnoli, Giulia Giacomucci, Juri Balestrini, Sonia Padiglioni, Giulia Tomaiuolo, Assunta Ingannato, Camilla Ferrari, Laura Bracco, Sandro Sorbi, Benedetta Nacmias
Summary: The study found an association between PER2 C111G polymorphism and language performance in SCD patients; as patients progress to MCI, carriers of the G allele showed greater worsening in cognitive performance; the effect of PER2 C111G polymorphism depends on the global cognitive status of patients.
Article
Clinical Neurology
Ketevan Toloraia, Antonia Meyer, Selina Beltrani, Peter Fuhr, Roselind Lieb, Ute Gschwandtner
Summary: This study suggests that anxiety may be a predictor of the development of MCI in PD patients, while depression and apathy do not seem to have a significant predictive value.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Fanny Urbain, Isabelle Hardy-Leger, Ghaidaa Adebs-Nasser, Mathilde de Menthon, Cecile Pivert, Aude Mausoleo, Ariane Laparra, Nathalie Lerolle, Paul-Albert Domnariu, Olivier Lambotte, Christian Denier, Cecile Goujard, Alicia Castro-Gordon, Nicolas Noel
Summary: This study investigated the psychological symptoms and cognitive impairment in patients with Behcet's disease. The findings suggest that some patients experience psychological problems and cognitive dysfunction, with anxiety, somatization, and phobia being the most common symptoms. Cognitive impairment is associated with disease activity score but not with brain MRI abnormalities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Davide Quaranta, Naike Caraglia, Federica L'Abbate, Guido Maria Giuffre, Valeria Guglielmi, Giovanna Masone Iacobucci, Paolo Maria Rossini, Paolo Calabresi, Camillo Marra
Summary: Early impairment of semantic memory could predict the progression to Alzheimer's disease before the onset of memory disorders, and the discrepancy between phonological and semantic verbal fluency tests could be able to detect this impairment in advance.
BRAIN AND BEHAVIOR
(2023)
Article
Public, Environmental & Occupational Health
Alejandro Gonzalez-Andrade, Amalia Garcia-Torres, Miguel Perez-Garcia, Esperanza Vergara-Moragues
Summary: The study found a significant relationship between executive functioning and instrumental skills in persons with HIV, with set-shifting being the strongest predictor. Executive functions, particularly set-shifting, are related to community living skills but not household living skills.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Psychology, Multidisciplinary
David J. Libon, Emily Frances Matusz, Stephanie Cosentino, Catherine C. Price, Rod Swenson, Meagan Vermeulen, Terrie Beth Ginsberg, Adaora Obiageli Okoli-Umeweni, Leonard Powell, Robert Nagele, Sean Tobyne, Joyce Rios Gomes-Osman, Alvaro Pascual-Leone
Summary: The Core Cognitive Evaluation (CCE), administered and scored using an iPad, is a powerful neurocognitive assessment tool for screening patients' neurocognitive impairment and psychological distress in ambulatory medical care settings. It is linked with patients' self-reported concerns about memory and cardiovascular risks.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Piercarlo Minoretti, Andres S. Santiago Saez, angel F. Garcia Martin, Miryam Liano Riera, Manuel Gomez Serrano, Enzo Emanuele
Summary: This study investigates the impact of depressive symptoms on executive functioning among airline pilots. The results show that 12% of the pilots exhibit mild depression, and they demonstrated longer reaction times and more errors in executive functioning tasks. These findings emphasize the importance of psychological well-being among pilots.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Psychiatry
Helen-Maria Vasiliadis, Isabelle Pitrou, Catherine Lamoureux-Lamarche, Sebastien Grenier, Patrick Viet-Quoc Nguyen, Carol Hudon
Summary: The study aimed to estimate the prevalence and incidence of late-life psychosis (LLP) in community-living older adults aged 65 and above, with a focus on factors such as functional status, physical diseases, hospitalizations, continuity of care, and physical activity. Results showed a 3-year prevalence of 4.7% and incidence of 2.8% for LLP, with various individual and health system factors influencing the development of LLP in primary care older adults. The findings emphasize the importance of improving continuity of care for at-risk older adults without dementia in primary care settings.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Isabelle Pitrou, Helen-Maria Vasiliadis, Carol Hudon
Summary: This study found that there is no direct association between BMI categories and cognitive decline in older adults, but high-intensity physical activity can reduce the risk of cognitive decline in overweight individuals.
EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
(2022)
Article
Neurosciences
Valerie Turcotte, Olivier Potvin, Mahsa Dadar, Carol Hudon, Simon Duchesne
Summary: This study examines the influence of birth cohorts and cognitive reserve (CR) on cognitive performance and structural brain health. The results show that recent birth cohorts, higher CR, and healthier brain structures are associated with better performance in verbal episodic memory, language and semantic memory, and attention capacities. The findings suggest that cohort differences in cognitive performance can be partly explained by proxies of CR.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Joel Macoir, Marie-Pier Tremblay, Maximiliano A. Wilson, Robert Laforce, Carol Hudon
Summary: The study aimed to investigate the role of semantic memory in emotion recognition of basic emotions conveyed by music in individuals with svPPA. Results showed that individuals with svPPA had preserved abilities to recognize familiar music but impaired performance on tasks involving semantic concepts and emotion recognition. Furthermore, recognition of basic emotions and association of musical excerpts with semantic concepts were better for familiar than non-familiar music excerpts in participants with svPPA.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Helen-Maria Vasiliadis, Isabelle Pitrou, Sebastien Grenier, Djamal Berbiche, Carol Hudon
Summary: This study identified profiles of aging based on psychological distress, cognition, and functional disability, and explored their associated factors. The results showed that symptoms of anxiety and depression, as well as high burden of physical disorders, were associated with less favorable trajectories of aging. Additionally, modifiable lifestyle factors were found to have a significant impact on healthy aging.
CLINICAL GERONTOLOGIST
(2023)
Article
Psychology, Clinical
Francois Quesque, Antoine Coutrot, Sharon Cox, Leonardo Cruz de Souza, Sandra Baez, Juan Felipe Cardona, Hannah Mulet-Perreault, Emma Flanagan, Alejandra Neely-Prado, Maria Florencia Clarens, Luciana Cassimiro, Gada Musa, Jennifer Kemp, Anne Botzung, Nathalie Philippi, Maura Cosseddu, Catalina Trujillo-Llano, Johan Sebastian Grisales-Cardenas, Sol Fittipaldi, Nahuel Magrath Guimet, Ismael Luis Calandri, Lucia Crivelli, Lucas Sedeno, Adolfo M. Garcia, Fermin Moreno, Begona Indakoetxea, Alberto Benussi, Millena Vieira Brandao Moura, Hernando Santamaria-Garcia, Diana Matallana, Galina Pryanishnikova, Anna Morozova, Olga Iakovleva, Nadezda Veryugina, Oleg Levin, Lina Zhao, Junhua Liang, Thomas Duning, Thibaud Lebouvier, Florence Pasquier, David Huepe, Myriam Barandiaran, Andreas Johnen, Elena Lyashenko, Ricardo F. Allegri, Barbara Borroni, Frederic Blanc, Fen Wang, Monica Sanches Yassuda, Patricia Lillo, Antonio Lucio Teixeira, Paulo Caramelli, Carol Hudon, Andrea Slachevsky, Agustin Ibanez, Michael Hornberger, Maxime Bertoux
Summary: Measures of social cognition are essential in neuropsychology for diagnoses and rehabilitation. International collaborations help tackle global mental health challenges, but differences between countries should not be ignored.
Article
Geriatrics & Gerontology
Patrick J. Bernier, Christian Gourdeau, Pierre-Hugues Carmichael, Jean-Pierre Beauchemin, Philippe Voyer, Carol Hudon, Robert Laforce
Summary: The Montreal Cognitive Assessment (MoCA) is a widely used cognitive screening tool for older adults. However, interpreting its scores over time and distinguishing between age-associated cognitive decline and early neurodegeneration remains unclear. In this study, the researchers aimed to create cognitive charts using the MoCA for longitudinal evaluation of age-associated cognitive decline in clinical practice. They developed a linear regression model and validated it using two separate data sets. The Cognitive Charts-MoCA showed high validity and diagnostic accuracy, providing a valuable tool for identifying abnormal cognitive performance in older individuals and initiating appropriate investigation and treatment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Mariane Landry, Marie-Michele Champagne, Charlotte Labrecque, Phylicia Verreault, Joel Macoir, Carol Hudon
Summary: This study aimed to provide normative data for the 12-item Buschke memory test in the Quebec-French population aged 50 and older. Results showed that age, years of formal education, and sex were associated with performance on the test. Normative data were provided in the form of Z-scores equations and percentiles. These findings are important for improving clinicians' accuracy in detecting verbal episodic memory impairments in Quebec's aging population.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Clinical Neurology
Joel Macoir, Carol Hudon
Summary: The aim of this study was to provide normative data for the verb fluency test in the adult population of French Quebec and to assess its discriminant validity and test-retest reliability. The results showed that age, sex, and education level were significantly related to performance on the test. The test was effective in distinguishing between healthy individuals and participants with mild cognitive impairment, and demonstrated good stability over time.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Clinical Neurology
Carol Hudon, Alexandre St-Hilaire, Mariane Landry, Florence Belzile, Joel Macoir
Summary: The present study aimed to establish normative data for the Drexel version of the Tower of London (ToL) among French-Quebec people aged 50 years and over. Results indicated that Total Execution Time was associated with age, whereas the Total Type II Errors and Total Rule Violation score were associated with both age and education level. Normative data are presented in the form of percentile ranks.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Psychology, Clinical
Joel Macoir, Carol Hudon
Summary: This study introduces two new verbal fluency tests, namely, extradimensional alternating fluency (EAF) and extradimensional orthographic constraint semantic fluency (EOCSF). The aim of Study 1 was to establish normative data for the tests in the adult and elderly population of French Quebec. The aim of Study 2 was to determine their psychometric value. Both tests proved to be useful in distinguishing healthy individuals from those with cognitive impairments.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Psychology, Clinical
Carol Hudon, Sylvie Belleville, Florence Belzile, Mariane Landry, Hannah Mulet-Perreault, Corinne Trudel, Joel Macoir
Summary: The present study aimed to establish normative data for the Judgment of Line Orientation (JLO) Test of Benton and found that JLO performance was positively associated with years of formal education and male sex, whereas it was negatively associated with age. The generated normative data will ease the detection of visuospatial impairment in French-Quebec middle-aged and older adults.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Neuroimaging
Marie-Eve Martineau-Dussault, Claire Andre, Veronique Daneault, Andree-Ann Baril, Katia Gagnon, Helene Blais, Dominique Petit, Jacques Y. Montplaisir, Dominique Lorrain, Celyne Bastien, Carol Hudon, Maxime Descoteaux, Arnaud Bore, Guillaume Theaud, Cynthia Thompson, Julie Legault, Guillermo E. Martinez Villar, Alexandre Lafreniere, Chantal Lafond, Danielle Gilbert, Julie Carrier, Nadia Gosselin
Summary: The study found that the association between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes is influenced by sex, age, cognitive status, and free-water fraction correction. Further research is needed to investigate whether the increase in medial temporal subregion volumes leads to neuronal death in untreated OSA patients.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Laurence Caron, Marie-Christine Ouellet, Carol Hudon, David Predovan, Marie-Josee Sirois, Elaine de Guise, Marie-Eve Lamontagne, Marcel Emond, Natalie Le Sage, Simon Beaulieu-Bonneau
Summary: This study investigated the objective and subjective cognitive functioning of older adults with TBI at the age of 65 or over. The results showed that subjective cognitive functioning was significantly associated with mental health-related quality of life.
Article
Geriatrics & Gerontology
Christine Gagnon, Miloudza Olmand, Emma Gabrielle Dupuy, Florent Besnier, Thomas Vincent, Catherine-Alexandra Gregoire, Marianne Levesque, Marie Payer, Beatrice Berube, Juliana Breton, Catia Lecchino, Nadia Bouabdallaoui, Josep Iglesies-Grau, Mathieu Gayda, Paolo Vitali, Anil Nigam, Martin Juneau, Carol Hudon, Louis Bherer
Summary: This study aimed to develop French-Quebec normative data for videoconference-administered MoCA, taking sociodemographic characteristics into consideration. The obtained normative data will enable clinicians to continue conducting remote assessments during the pandemic and perform cognitive assessments for patients in remote areas.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)